2009
DOI: 10.1038/aps.2009.8
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Dauricine inhibits insulin-like growth factor-I-induced hypoxia inducible factor 1α protein accumulation and vascular endothelial growth factor expression in human breast cancer cells

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Cited by 41 publications
(30 citation statements)
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“…Recently, it has been shown that the expression of HIF-1α can be upregulated not only by hypoxia, but also by other nonhypoxic factors, such as the inactivation of tumor-suppressor genes (p53, pVHL, and PTEN [35,36,37]), activation of some viral oncoproteins (EBV and HPV-16 [38,39]), and challenge by IGF-I [40,41,42], etc. In the present study, the human NSCLC cell line A549 was used to investigate the effect of EGCG on the IGF-I-induced HIF-1α and VEGF expression and the proangiogenic activity of human lung cancer cells.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, it has been shown that the expression of HIF-1α can be upregulated not only by hypoxia, but also by other nonhypoxic factors, such as the inactivation of tumor-suppressor genes (p53, pVHL, and PTEN [35,36,37]), activation of some viral oncoproteins (EBV and HPV-16 [38,39]), and challenge by IGF-I [40,41,42], etc. In the present study, the human NSCLC cell line A549 was used to investigate the effect of EGCG on the IGF-I-induced HIF-1α and VEGF expression and the proangiogenic activity of human lung cancer cells.…”
Section: Discussionmentioning
confidence: 99%
“…It was proved to suppress proliferation and invasion and induce apoptosis of HCT116 and HCT8 human colon cancer cells by blocking the NF-κB signaling pathway (79). In the MCF-7 human breast cancer line and HUVECs human umbilical vein endothelial cells, dauricine plays a role in inhibiting angiogenesis of cancer cells by blocking the PI3K/Akt/mTOR pathway and HIF-1α pathway (80).…”
Section: Berbamine and Its Structural Analoguesmentioning
confidence: 99%
“…1 for their chemical structures). Dauricine, a calcium channel blocker, is the main toxin that makes M. dauricum poisonous [4], has been studied by many scientists for its high pharmacological activities [5][6][7]. However, little pharmacological research has been done on its structure analogues such as daurisolin, daurinoline and dauricicoline.…”
Section: Introductionmentioning
confidence: 99%