Day-to-day repeatability of the Pulse Time Index of Norm

Posokhov, Igor; Конради, А. О.; Shlyakhto, Е. V.; Mamontov, Oleg V.; Orlov, A. V.; Rogoza, A. N.

doi:10.2147/mder.s58507

Cited by 9 publications

(9 citation statements)

References 19 publications

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“…Our previous work on the reliability of PTIN shows its good repeatability 22. Thus, given the above results, we believe that the PTIN especially during the “asleep” period should also be considered in forthcoming research.…”

Section: Discussionsupporting

confidence: 53%

The "Pulse Time Index of Norm" highly correlates with the left ventricular mass index in patients with arterial hypertension

Posokhov¹,

Kulikova²,

Starchenkova³

et al. 2014

VHRM

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BackgroundArterial stiffness, as measured by the pulse wave velocity (PWV), is recommended for routine use in clinical practice as an important parameter for the evaluation of cardiovascular risk.1 New 24-hour monitors (eg, with Vasotens® technology; Petr Telegin Company, Nizhny Novgorod, Russian Federation) provide single PWV measurements as well as several PWV measurements over a period of 24 hours.2 Such 24-hour pulse wave analysis led to the development of the novel Pulse Time Index of Norm (PTIN), which is defined as the percentage of a 24-hour period during which the PWV does not exceed the 10 m/second PWV threshold. The aim of this study is to test the new PTIN for correlation with the left ventricular mass index (LVMI).MethodsOscillometrically generated waveform files (n=137) used for clinical research studies were reanalyzed using the new 2013 version of the Vasotens technology program, which enables PTIN calculations.ResultsA good correlation (r=−0.72) between the PTIN and the LVMI was shown, which was significantly above the blood pressure load (r=0.41).ConclusionThe PTIN generated by the Vasotens technology can be recommended as an indicator of end organ damage via hypertension.

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Section: Discussionsupporting

confidence: 53%

The "Pulse Time Index of Norm" highly correlates with the left ventricular mass index in patients with arterial hypertension

Posokhov¹,

Kulikova²,

Starchenkova³

et al. 2014

VHRM

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“…The difference in time between the first wave and the second wave (i.e., the reflected wave) correlates to the distance, according to the manufacturer's instructions, and allows calculation of the pulse wave velocity (PWV). A detailed description of the Vasotens methodology may be found in previous publications [ 10 , 12 , 17 ].…”

Section: Methodsmentioning

confidence: 99%

Evaluation of 24-Hour Arterial Stiffness Indices and Central Hemodynamics in Healthy Normotensive Subjects versus Treated or Untreated Hypertensive Patients: A Feasibility Study

Omboni

Posokhov²,

Рогоза

2015

International Journal of Hypertension

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Objective. Central blood pressure (BP) and vascular indices estimated noninvasively over the 24 hours were compared between normotensive volunteers and hypertensive patients by a pulse wave analysis of ambulatory blood pressure recordings. Methods. Digitalized waveforms obtained during each brachial oscillometric BP measurement were stored in the device memory and analyzed by the validated Vasotens technology. Averages for the 24 hours and for the awake and asleep subperiods were computed. Results. 142 normotensives and 661 hypertensives were evaluated. 24-hour central BP, pulse wave velocity (PWV), and augmentation index (AI) were significantly higher in the hypertensive group than in the normotensive group (119.3 versus 105.6 mmHg for systolic BP, 75.6 versus 72.3 mmHg for diastolic BP, 10.3 versus 10.0 m/sec for aortic PWV, −9.7 versus −40.7% for peripheral AI, and 24.7 versus 11.0% for aortic AI), whereas reflected wave transit time (RWTT) was significantly lower in hypertensive patients (126.6 versus 139.0 ms). After adjusting for confounding factors a statistically significant between-group difference was still observed for central BP, RWTT, and peripheral AI. All estimates displayed a typical circadian rhythm. Conclusions. Noninvasive assessment of 24-hour arterial stiffness and central hemodynamics in daily life dynamic conditions may help in assessing the arterial function impairment in hypertensive patients.

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“…The accuracy of this device has previously been validated for ABPM 5. There have been other validations for vascular indexes 6–8. The principle of the oscillometric method is based on plethysmography and registers pulsatile pressure changes in the brachial artery.…”

Section: Methodsmentioning

confidence: 99%

The 24-hour pulse wave velocity, aortic augmentation index, and central blood pressure in normotensive volunteers

Kuznetsova¹,

Korneva²,

Bryantseva

et al. 2014

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The purpose of this study was to examine the pulse wave velocity, aortic augmentation index corrected for heart rate 75 (AIx@75), and central systolic and diastolic blood pressure during 24-hour monitoring in normotensive volunteers. Overall, 467 subjects (206 men and 261 women) were recruited in this study. Participants were excluded from the study if they were less than 19 years of age, had blood test abnormalities, had a body mass index greater than 2 7.5 kg/m2, had impaired glucose tolerance, or had hypotension or hypertension. Ambulatory blood pressure monitoring (ABPM) with the BPLab® device was performed in each subject. ABPM waveforms were analyzed using the special automatic Vasotens® algorithm, which allows the calculation of pulse wave velocity, AIx@75, central systolic and diastolic blood pressure for “24-hour”, “awake”, and “asleep” periods. Circadian rhythms and sex differences in these indexes were identified. Pending further validation in prospective outcome-based studies, our data may be used as preliminary diagnostic values for the BPLab ABPM additional index in adult subjects.

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Day-to-day repeatability of the Pulse Time Index of Norm

Cited by 9 publications

References 19 publications

The "Pulse Time Index of Norm" highly correlates with the left ventricular mass index in patients with arterial hypertension

The "Pulse Time Index of Norm" highly correlates with the left ventricular mass index in patients with arterial hypertension

Evaluation of 24-Hour Arterial Stiffness Indices and Central Hemodynamics in Healthy Normotensive Subjects versus Treated or Untreated Hypertensive Patients: A Feasibility Study

The 24-hour pulse wave velocity, aortic augmentation index, and central blood pressure in normotensive volunteers

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Day-to-day repeatability of the Pulse Time Index of Norm

Cited by 9 publications

References 19 publications

The &quot;Pulse Time Index of Norm&quot; highly correlates with the left ventricular mass index in patients with arterial hypertension

The &quot;Pulse Time Index of Norm&quot; highly correlates with the left ventricular mass index in patients with arterial hypertension

Evaluation of 24-Hour Arterial Stiffness Indices and Central Hemodynamics in Healthy Normotensive Subjects versus Treated or Untreated Hypertensive Patients: A Feasibility Study

The 24-hour pulse wave velocity, aortic augmentation index, and central blood pressure in normotensive volunteers

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The "Pulse Time Index of Norm" highly correlates with the left ventricular mass index in patients with arterial hypertension

The "Pulse Time Index of Norm" highly correlates with the left ventricular mass index in patients with arterial hypertension