Daylight photodynamic therapy for the treatment of actinic cheilitis

Levi, Assi; Hodak, Emmilia; Enk, Claes D.; Snast, Igor; Slodownik, Dan; Lapidoth, Moshe

doi:10.1111/phpp.12415

Cited by 24 publications

(24 citation statements)

References 30 publications

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“…Two recent publications detail DL MAL‐PDT for actinic cheilitis which achieved sustained response in 5/10 patients over 6–12 months of follow‐up in a study of two treatments 7–14 days apart, whilst a 91% cure rate in 10/11 patients was achieved using repeated treatments – mean 2.8 …”

Section: Current Indicationsmentioning

confidence: 99%

“…94 Two recent publications detail DL MAL-PDT for actinic cheilitis which achieved sustained response in 5/10 patients over 6-12 months of follow-up in a study of two treatments 7-14 days apart, whilst a 91% cure rate in 10/11 patients was achieved using repeated treatmentsmean 2.8. 95,96 Therapy guidelines identify PDT as effective both as a lesion and field-directed treatment and suggest PDT has a role where AKs are multiple/clustered, as a suitable choice for patients wishing to manage background actinic changes, and as part of maintenance treatment for low-grade AKs in sun damaged skin. 97,98 PDT remains a predominantly hospital-based therapy in most countries whilst many patients with AK are treated by primary care physicians.…”

Section: Current Indicationsmentioning

confidence: 99%

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European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications – actinic keratoses, Bowen's disease and basal cell carcinomas

Morton¹,

Szeimies

Basset-Séguin

et al. 2019

Acad Dermatol Venereol

148

146

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Topical photodynamic therapy (PDT) is a widely approved therapy for actinic keratoses, Bowen's disease (squamous cell carcinoma in situ), superficial and certain thin basal cell carcinomas. Recurrence rates when standard treatment protocols are used are typically equivalent to existing therapies, although inferior to surgery for nodular basal cell carcinoma. PDT can be used both as lesional and field therapies and has the potential to delay/reduce the development of new lesions. A protocol using daylight to treat actinic keratoses is widely practised, with conventional PDT using a red light after typically a 3‐h period of occlusion employed for other superficial skin cancer indications as well as for actinic keratoses when daylight therapy is not feasible. PDT is a well‐tolerated therapy although discomfort associated with conventional protocol may require pain‐reduction measures. PDT using daylight is associated with no or minimal pain and preferred by patient. There is an emerging literature on enhancing conventional PDT protocols or combined PDT with another treatment to increase response rates. This guideline, published over two parts, considers all current approved and emerging indications for the use of topical PDT in dermatology, prepared by the PDT subgroup of the European Dermatology Forum guidelines committee. It presents consensual expert recommendations reflecting current published evidence.

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Section: Current Indicationsmentioning

confidence: 99%

Section: Current Indicationsmentioning

confidence: 99%

European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications – actinic keratoses, Bowen's disease and basal cell carcinomas

Morton¹,

Szeimies

Basset-Séguin

et al. 2019

Acad Dermatol Venereol

148

146

View full text Add to dashboard Cite

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“…PDT can be effective in the treatment of periocular tumours in selected patients. For actinic cheilitis (lip region), PDT (conventional and daylight) is a very good option, which is often described in the literature with good response . Pain seems to be the main limiting factor for PDT around the eyelids and lips.…”

Section: Topical Therapiesmentioning

confidence: 99%

Cutaneous squamous cell carcinomas on special locations: perioral, periocular and genital area

Nägeli

Ramelyte

Dummer

2019

Acad Dermatol Venereol

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If tumours arise in special locations such as around the eyes, mouth or in the genital area, patients and physicians are challenged by the need for complete removal of the tumour with safety margins and high demands on function and aesthetic aspects. Treatment should be performed by specialized physicians including ophthalmologists, head and neck surgeons, surgical, medical and radiation oncologists. The first-line treatment for most cutaneous malignancies is surgical excision; however, in several situations, such as well-differentiated cutaneous squamous cell carcinomas (cSCC) in the periocular or anal region, radiotherapy is a very reasonable and sometimes treatment of first choice, especially in patients with advanced age. In periocular SCC, radiotherapy with superficial x-ray combined with eye shielding, while in anal SCC, radiotherapy combined with chemotherapy is recommended. However, after failure of local treatment options including surgery and radiotherapy, systemic medications are indicated in order to achieve tumour control or cure. Systemic therapies include immunotherapy, targeted therapy or chemotherapy. Preventive strategies are based on UV protection in facial, and vaccination in HPV associated anogenital SCCs.

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“…5 It causes substantially less procedurerelated pain than conventional PDT yet with comparable efficacy in various dermatological diseases. 6,7 Hand eczema is a common inflammatory skin condition. It may be caused by various exogenous factors (eg, allergic and irritant contact dermatitis) or endogenous factors (eg, atopic dermatitis).…”

Section: Introductionmentioning

confidence: 99%

“…Daylight‐activated PDT (DL‐PDT) uses natural daylight as the light source for the procedure 5 . It causes substantially less procedure‐related pain than conventional PDT yet with comparable efficacy in various dermatological diseases 6,7 …”

Section: Introductionmentioning

confidence: 99%

Self‐administered daylight‐activated photodynamic therapy for the treatment of hand eczema: A prospective proof‐of‐concept study

Kremer

Sherman

Lapidoth

et al. 2020

Dermatologic Therapy

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Daylight photodynamic therapy for the treatment of actinic cheilitis

Abstract: Daylight PDT is a promising modality for the treatment of AC, with impressive cosmetic results and few side effects.

Cited by 24 publications

References 30 publications

European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications – actinic keratoses, Bowen's disease and basal cell carcinomas

European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications – actinic keratoses, Bowen's disease and basal cell carcinomas

Cutaneous squamous cell carcinomas on special locations: perioral, periocular and genital area

Self‐administered daylight‐activated photodynamic therapy for the treatment of hand eczema: A prospective proof‐of‐concept study

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