Daylight photodynamic therapy with methylene blue in plane warts: a randomized double‐blind placebo‐controlled study

Fathy, Ghada; Asaad, Marwa K.; Rasheed, Haval Mohamad

doi:10.1111/phpp.12291

Cited by 15 publications

(6 citation statements)

References 20 publications

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“…Other treatment modalities for warts include aPDT with 10% MB, which has yielded positive results. This treatment can be conducted using daylight, considerably reducing pain and costs (Fathy et al, 2017).…”

Section: Apdt For Human Papillomavirusmentioning

confidence: 99%

Antimicrobial photodynamic therapy for dermatological infections: current insights and future prospects

Almenara-Blasco,

Pérez-Laguna,

Navarro-Bielsa

et al. 2024

Front. Photobiol.

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Introduction:Light-based antimicrobial photodynamic therapy (aPDT) shows promise against a wide range of microorganisms, including drug-resistant strains, with low resistance development likelihood. However, its limitations include the need for light exposure, suitability for local infections, and limited industry interest. Relevant studies on aPDT for various infections are discussed.Methods:We conducted an extensive literature review on aPDT encompassing articles published from the year 2000 to the current date. To compile comprehensive data, multiple databases (PubMed, Web of Science, Scopus, and Cochrane Library) were systematically searched for relevant studies in both English and Spanish languages. The search strategy involved a combination of Medical Subject Headings (MeSH) terms and free-text terms. The terms included variations and combinations of “Antimicrobial Photodynamic Therapy,” “aPDT,” “photodynamic inactivation,” “microbial photoinactivation,” among others. To ensure the reliability and quality of the information gathered, articles were screened based on relevance to aPDT in antimicrobial therapy, methodological rigor, and alignment with the objectives of this review.Results:aPDT shows promise in treating various cutaneous infections. It effectively targets fungal infections, including caused by dermatophytes and Malassezia spp., with notable results against dermatophytosis and tinea capitis. New photosensitizers, like nanoencapsulated hypericin, hold potential for treating these infections. In onychomycosis, aminolevulinic acid-aPDT or methylene blue-aPDT offers an alternative to conventional therapies, showing cure rates as high as 90%. For bacterial infections, it presents a solution against antibiotic-resistant strains and infected ulcers, with potential benefits for wound healing. Regarding viral infections, it indirectly targets viruses by impacting host cells’ metabolism, showing efficacy against human papillomavirus and herpes viruses. Lastly, aPDT demonstrates success in treating parasitic infections, particularly leishmaniasis, with cure rates of up to 100%.Discussion:aPDT is increasingly used in dermatological infections, showing efficacy against various microorganisms and stimulating wound healing. It can combat resistant strains and mixed infections, especially in chronic wounds. Combining photodynamic therapy with antimicrobials is a promising strategy to address antimicrobial resistance, but there are practical limitations. Further research is needed for home-based protocols, portable devices, and adapting photosensitizers, as aPDT holds potential as an alternative treatment for recalcitrant infections and immunosuppressed patients, though challenges remain in application.

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Section: Apdt For Human Papillomavirusmentioning

confidence: 99%

Antimicrobial photodynamic therapy for dermatological infections: current insights and future prospects

Almenara-Blasco,

Pérez-Laguna,

Navarro-Bielsa

et al. 2024

Front. Photobiol.

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“…Schmerzen und vorübergehende Hyperpigmentierung sind die einzigen Nebenwirkungen der PDT für Warzen. Schmerzen während und nach (bis zu 24 Stunden) Lichtexposition werden jedoch von etwa 20 % der Patienten als schwerwiegend oder unerträglich beschrieben [94, 95, 98, 99], und leider wurden bisher keine wirksamen Methoden zu ihrer Verringerung vorgeschlagen.…”

Section: Grundlagen Der Pdtunclassified

“…In einer randomisierten, doppelblinden, placebokontrollierten Studie wurden plane Warzen erfolgreich mit Tageslicht PDT mit topischem 10 % Methylenblau-Gel behandelt. Im Gegensatz zu ALA/MAL PDT war die Behandlung fast schmerzlos [98], und wir betonen, dass sie auch viel preisgünstiger ist.…”

Section: Grundlagen Der Pdtunclassified

Eine kritische Neubewertung der Off-Label-Anwendung der photodynamischen Therapie zur Behandlung von nicht neoplastischen Hauterkrankungen

Monfrecola¹,

Megna²,

Rovati

et al. 2022

Kompass Dermatol

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Hintergrund: In den letzten 30 Jahren wurde die topische photodynamische Therapie (PDT) zur Behandlung eines breiten Spektrums von kosmetischen, entzündlichen und infektiösen Hauterkrankungen mit variablen und oft kontrastierenden Ergebnissen untersucht. Allerdings kann es für den nicht fachkundigen Arzt schwierig sein, diese Ergebnisse zu bewerten, da verschiedene empfindlichkeitssteigernde Stoffe, Konzentrationen, Formulierungen, Lichtquellen und Bestrahlungsprotokolle verwendet wurden. Darüber hinaus haben viele dieser Studien als Fallberichte und unkontrollierte Studien von wenigen Fällen eine schlechte Design-Qualität. Zusammenfassung: Mit dem Ziel, den potenziellen Nutzen von PDT für die Behandlung von infektiösen und entzündlichen Hauterkrankungen sowie ausgewählten kosmetischen Indikationen zu klären, suchten wir nach randomisierten kontrollierten klinischen Studien, nicht randomisierten Vergleichsstudien, retrospektiven Studien und Fallreihenstudien mit einer Anzahl von mindestens 10 Patienten, die seit 1990 veröffentlicht wurden. Später haben wir die Ergebnisse neu bewertet, um einen einfachen kritischen Überblick zu geben. Die Kernbotschaften: Literaturbelege scheinen die Verwendung von ALA- und MAL-PDT zur Behandlung von häufigen Hauterkrankungen wie Akne, Warzen, Kondylomen und Leishmania-Hautinfektionen sowie zur Photorejuvenation, d. h. zur kosmetischen Korrektur ausgewählter kosmetischer Alterungs- und Lichtalterungsschäden stark zu unterstützen. Für andere Erkrankungen sind die Evidenz und die Stärke der Empfehlung niedriger, und kontrollierte randomisierte Studien mit verlängerten Nachbeobachtungen sind notwendig, um den klinischen Nutzen und andere potenzielle Vorteile gegenüber den aktuellen Behandlungsoptionen zu beurteilen.

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“…Pain and transient hyperpigmentation are the only adverse effects of PDT for warts. However, pain during and after (up to 24 h) light exposure is described as severe or unbearable by about 20% of patients [94, 95, 98, 99] and, unfortunately, effective methods to decrease it have not been suggested so far.…”

Section: Skin Infectionsmentioning

confidence: 99%

“…In a randomized double-blind placebo-controlled study, plane warts were successfully treated with daylight PDT with topical 10% methylene blue gel. Unlike ALA/MAL PDT the treatment was almost painless [98], and we emphasize that it is also much cheaper.…”

Section: Skin Infectionsmentioning

confidence: 99%

A Critical Reappraisal of Off-Label Use of Photodynamic Therapy for the Treatment of Non-Neoplastic Skin Conditions

et al. 2020

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Background: In the past 30 years, topical photodynamic therapy (PDT) has been investigated for the treatment of a broad spectrum of cosmetic, inflammatory, and infectious skin conditions with variable, and often contrasting, results. However, the non-expert clinician may be in difficulty evaluating these results because different sensitizers, concentrations, formulations, light sources, and irradiation protocols have been used. In addition, many of these studies have poor quality design being case reports and uncontrolled studies of few cases. Summary: With the aim to clarify the potential usefulness of PDT for the treatment of infectious and inflammatory skin diseases as well as selected cosmetic indications, we searched for randomized controlled clinical trials, non-randomized comparative studies, retrospective studies, and case series studies with a number of at least 10 patients, published since 1990. Later, we reappraised the results in order to give a simple critical overview. Key Messages: Evidence from the literature seems to strongly support the use of ALA- and MAL-PDT for the treatment of common skin diseases such as acne, warts, condylomata, and Leishmania skin infection and for photorejuvenation, i.e., the correction of selected cosmetic changes of aging and photoaging. For other disorders, the level of evidence and strength of recommendation are lower, and controlled randomized studies with prolonged follow-ups are necessary in order to assess the clinical usefulness and other potential advantages over current treatment options.

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Daylight photodynamic therapy with methylene blue in plane warts: a randomized double‐blind placebo‐controlled study

Abstract: Daylight-PDT using MB is safe, easy to carry out, economic, effective, acceptable cosmetic results with no recurrence, convenient especially for children and nearly painless treatment.

Cited by 15 publications

References 20 publications

Antimicrobial photodynamic therapy for dermatological infections: current insights and future prospects

Antimicrobial photodynamic therapy for dermatological infections: current insights and future prospects

Eine kritische Neubewertung der Off-Label-Anwendung der photodynamischen Therapie zur Behandlung von nicht neoplastischen Hauterkrankungen

A Critical Reappraisal of Off-Label Use of Photodynamic Therapy for the Treatment of Non-Neoplastic Skin Conditions

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