This study comprehensively evaluates the energy-saving potential and visual comfort aspects of electrochromic (EC) smart windows in a hot-humid climate office building. Using an advanced building simulation tool, EC windows are compared to conventional low-E glazed windows, considering two control triggers: daylighting level and glare control. The primary objective is to determine energy savings achievable with EC windows while addressing visual comfort. Detailed analysis of the building’s energy performance and indoor environment is conducted. Results show significant energy savings of 23% with EC windows using daylighting control but limited visual comfort in some zones. Conversely, EC windows with glare control achieve 17% energy savings while maintaining visual comfort throughout the building. These findings highlight the potential of EC windows with glare control in saving energy and maintaining visual comfort in hot-humid office buildings. Further research is needed to optimize performance for different building types and climates. In conclusion, this study provides insights into energy-saving capabilities and visual comfort considerations with EC smart windows, emphasizing the importance of appropriate control triggers for maximizing energy savings and occupant comfort. Future investigations should explore EC window performance across diverse building typologies and climates to enhance the benefits of this innovative technology.