Daytime sleepiness is associated with hyperhomocysteinemia in rural area of China: A cross-sectional study

Zhang, Naijin; Chen, Shuang; Chen, Yintao; Guo, Xiaofan; Sun, Guozhe; Hao, Qian; Sun, Yingxian

doi:10.1016/j.ejim.2016.05.029

Cited by 4 publications

(1 citation statement)

References 37 publications

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“…The following hypotheses motivated our approach: 1) the association between HCY-TAC will be stronger in MCI than in HO. This assumption is based on the fact that a combined pattern of elevated HCY and decreased TAC was more specific to MCI/AD than increased HCY levels alone 15 , which is considered a non-specific risk factor for a variety of neurodegenerative conditions 16 ; 2) the relationship between HCY-sleep will be present in both HO and MCI, as inferred from studies showing that elevated HCY levels are more frequent in subjects with a short sleep duration regardless of their clinical status 17 ; 3) MCI patients will show a stronger relationship between sleep-TAC than HO subjects, as supported by evidence showing associations between shorter sleep durations and decreased TAC levels in different clinical populations compared with normal subjects 18 , 19 ; and 4) all these factors (i.e., HCY, TAC and sleep) will be related to each other in MCI because of their well-recognized effects on Aβ accumulation, which would account for HCY-sleep associated patterns of brain atrophy 11 .…”

Section: Introductionmentioning

confidence: 99%

Sleep mediates the association between homocysteine and oxidative status in mild cognitive impairment

Sanchez-Espinosa

Atienza

Cantero

2017

Sci Rep

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Tremendous progress has been made over the last few years in understanding how sleep and amyloid-β (Aβ) cooperate to speed up the progression of Alzheimer’s disease (AD). However, it remains unknown whether sleep deficits also interact with other risk factors that exacerbate the pathological cascade of AD. Based on evidence showing that higher levels of homocysteine (HCY) and sleep loss increase oxidative damage, we here investigate whether the relationship between HCY and total antioxidant capacity (TAC) is mediated by changes in objective sleep in healthy older (HO, N = 21) and mild cognitive impairment (MCI, N = 21) subjects. Results revealed that reduced TAC levels in MCI was significantly correlated with increased HCY, shorter sleep duration, lower sleep efficiency, and reduced volume of temporal regions. However, only the HCY-TAC association showed diagnostic value, and this relationship was mediated by poorer sleep quality in MCI patients. We further showed that HCY-related cerebral volume loss in MCI depended on the serial relationship between poorer sleep quality and lower TAC levels. These findings provide novel insights into how impaired sleep may contribute to maintain the relationship between HCY and oxidative stress in prodromal AD, and offer empirical foundations to design therapeutic interventions aimed to weaken this link.

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Section: Introductionmentioning

confidence: 99%

Sleep mediates the association between homocysteine and oxidative status in mild cognitive impairment

Sanchez-Espinosa

Atienza

Cantero

2017

Sci Rep

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Validity of cardiometabolic index, lipid accumulation product, and body adiposity index in predicting the risk of hypertension in Chinese population

Wang

Chen

Sun

et al. 2018

Postgraduate Medicine

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Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins

Tabibzadeh¹

2022

Aging and disease

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According to the cell centric hypotheses, the deficits that drive aging occur within cells by age dependent progressive damage to organelles, telomeres, biologic signaling pathways, bioinformational molecules, and by exhaustion of stem cells. Here, we amend these hypotheses and propose an eco-centric model for geroplasticity (aging plasticity including aging reversal). According to this model, youth and aging are plastic and require constant maintenance, and, respectively, engage a host of endogenous rejuvenating (rejuvenins) and gero-inducing [geriatrin] factors. Aging in this model is akin to atrophy that occurs as a result of damage or withdrawal of trophic factors. Rejuvenins maintain and geriatrins adversely impact cellular homeostasis, cell fitness, and proliferation, stem cell pools, damage response and repair. Rejuvenins reduce and geriatrins increase the age-related disorders, inflammatory signaling, and senescence and adjust the epigenetic clock. When viewed through this perspective, aging can be successfully reversed by supplementation with rejuvenins and by reducing the levels of geriatrins.

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Daytime sleepiness is associated with hyperhomocysteinemia in rural area of China: A cross-sectional study

Cited by 4 publications

References 37 publications

Sleep mediates the association between homocysteine and oxidative status in mild cognitive impairment

Sleep mediates the association between homocysteine and oxidative status in mild cognitive impairment

Validity of cardiometabolic index, lipid accumulation product, and body adiposity index in predicting the risk of hypertension in Chinese population

Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins

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