Daytime variation in SARS-CoV-2 infection and cytokine production

Diallo, Aïssatou Bailo; Gay, Laetitia; Coiffard, Benjamin; Léone, Marc; Mezouar, Soraya; Mège, Jean‐Louis

doi:10.1016/j.micpath.2021.105067

Cited by 18 publications

(11 citation statements)

References 24 publications

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“…S2B and S3B), a circadian rhythm in viral replication may also contribute. Regulation and responsiveness of the immune system have been linked to circadian rhythms ( 28 , 29 ), shown to affect SARS-CoV-2 infection of monocytes in cell culture ( 30 ) and proposed as a modulating factor for COVID-19 severity and management ( 31 ). Others have proposed cellular interactions between viral proteins and circadian rhythm-dependent host signals ( 32 ) and demonstrated circadian rhythm-dependent entry and proliferation of SARS-CoV-2 in lung epithelial cell types in culture ( 33 ).…”

Section: Discussionmentioning

confidence: 99%

Morning SARS-CoV-2 Testing Yields Better Detection of Infection Due to Higher Viral Loads in Saliva and Nasal Swabs upon Waking

et al. 2022

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Our findings suggest that collecting saliva and nasal swab specimens in the morning immediately after waking yields higher SARS-CoV-2 viral loads than collection later in the day. The higher viral loads from morning specimen collection are predicted to significantly improve detection of SARS-CoV-2 in symptomatic individuals, particularly when using moderate- to low-analytical-sensitivity COVID-19 diagnostic tests, such as rapid antigen tests.

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Section: Discussionmentioning

confidence: 99%

Morning SARS-CoV-2 Testing Yields Better Detection of Infection Due to Higher Viral Loads in Saliva and Nasal Swabs upon Waking

et al. 2022

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“…Moreover, it is known that several aspects of the human immune system are under control of the circadian clock, including the regulation of inflammatory cytokines, neutrophil maturation, and the differentiation of immune cells, such as Th-cells [ 82 , 83 ]. Thus, the circadian clock could affect the host’s immune response [ 84 ].…”

Section: Exploring Underlying Molecular Mechanismsmentioning

confidence: 99%

COVID-19 in Joint Ageing and Osteoarthritis: Current Status and Perspectives

Lauwers

Yuan

et al. 2022

IJMS

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COVID-19 is a trending topic worldwide due to its immense impact on society. Recent trends have shifted from acute effects towards the long-term morbidity of COVID-19. In this review, we hypothesize that SARS-CoV-2 contributes to age-related perturbations in endothelial and adipose tissue, which are known to characterize the early aging process. This would explain the long-lasting symptoms of SARS-CoV-2 as the result of an accelerated aging process. Connective tissues such as adipose tissue and musculoskeletal tissue are the primary sites of aging. Therefore, current literature was analyzed focusing on the musculoskeletal symptoms in COVID-19 patients. Hypovitaminosis D, increased fragility, and calcium deficiency point towards bone aging, while joint and muscle pain are typical for joint and muscle aging, respectively. These characteristics could be classified as early osteoarthritis-like phenotype. Exploration of the impact of SARS-CoV-2 and osteoarthritis on endothelial and adipose tissue, as well as neuronal function, showed similar perturbations. At a molecular level, this could be attributed to the angiotensin-converting enzyme 2 expression, renin-angiotensin system dysfunction, and inflammation. Finally, the influence of the nicotinic cholinergic system is being evaluated as a new treatment strategy. This is combined with the current knowledge of musculoskeletal aging to pave the road towards the treatment of long-term COVID-19.

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“…Moreover, circadian rhythms regulate many gastrointestinal physiological processes, including cell proliferation, motility, digestion, absorption, mucosal secretions, and electrolyte balance [64]. Circadian rhythm was recently suggested as a regulator of viral infections, and in particular, experimental evidence supports the involvement of circadian rhythms in COVID-19 progression [65]. Supporting our results, circadian rhythm as an evolutionarily conserved pathway was suggested as a new target for reducing the risk of COVID-19 infection, as well as for developing diagnostic and therapeutic strategies [66,67].…”

Section: Circadian Rhythms Involved In Gi Function and Contribution To Covid-19mentioning

confidence: 99%

Ace2 and Tmprss2 Expressions Are Regulated by Dhx32 and Influence the Gastrointestinal Symptoms Caused by SARS-CoV-2

Gao

Orgil

et al. 2021

JPM

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Studies showed that the gastrointestinal (GI) tract is one of the most important pathways for SARS-CoV-2 infection and coronavirus disease 2019 (COVID-19). As SARS-CoV-2 cellular entry depends on the ACE2 receptor and TMPRSS2 priming of the spike protein, it is important to understand the molecular mechanisms through which these two proteins and their cognate transcripts interact and influence the pathogenesis of COVID-19. In this study, we quantified the expression, associations, genetic modulators, and molecular pathways for Tmprss2 and Ace2 mRNA expressions in GI tissues using a systems genetics approach and the expanded family of highly diverse BXD mouse strains. The results showed that both Tmprss2 and Ace2 are highly expressed in GI tissues with significant covariation. We identified a significant expression quantitative trait locus on chromosome 7 that controls the expression of both Tmprss2 and Ace2. Dhx32 was found to be the strongest candidate in this interval. Co-expression network analysis demonstrated that both Tmprss2 and Ace2 were located at the same module that is significantly associated with other GI-related traits. Protein–protein interaction analysis indicated that hub genes in this module are linked to circadian rhythms. Collectively, our data suggested that genes with circadian rhythms of expression may have an impact on COVID-19 disease, with implications related to the timing and treatment of COVID-19.

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Daytime variation in SARS-CoV-2 infection and cytokine production

Cited by 18 publications

References 24 publications

Morning SARS-CoV-2 Testing Yields Better Detection of Infection Due to Higher Viral Loads in Saliva and Nasal Swabs upon Waking

Morning SARS-CoV-2 Testing Yields Better Detection of Infection Due to Higher Viral Loads in Saliva and Nasal Swabs upon Waking

COVID-19 in Joint Ageing and Osteoarthritis: Current Status and Perspectives

Ace2 and Tmprss2 Expressions Are Regulated by Dhx32 and Influence the Gastrointestinal Symptoms Caused by SARS-CoV-2

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