2016
DOI: 10.1242/jcs.179218
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DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation

Abstract: Meiotic progression requires exquisitely coordinated translation of maternal messenger (m)RNA that has accumulated during oocyte growth. A major regulator of this program is the cytoplasmic polyadenylation element binding protein 1 (CPEB1). However, the temporal pattern of translation at different meiotic stages indicates the function of additional RNA binding proteins (RBPs). Here, we report that deleted in azoospermia-like (DAZL) cooperates with CPEB1 to regulate maternal mRNA translation. Using a strategy t… Show more

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Cited by 91 publications
(99 citation statements)
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“…The availability of a conditional DAZL is also highly expressed in ovary, in oocytes of all stages (see Supplementary Fig. S3A) (22,35). Full body Dazl knockout led to an ovary without any follicles, similar to the previously reported knockout (see Supplementary Fig.…”
Section: Removal Of Dazl In Gonocytes Spermatogonia and Spermatocytesupporting
confidence: 81%
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“…The availability of a conditional DAZL is also highly expressed in ovary, in oocytes of all stages (see Supplementary Fig. S3A) (22,35). Full body Dazl knockout led to an ovary without any follicles, similar to the previously reported knockout (see Supplementary Fig.…”
Section: Removal Of Dazl In Gonocytes Spermatogonia and Spermatocytesupporting
confidence: 81%
“…Given the requirement of DAZL throughout spermatogenesis, we next examined the mechanism of DAZL action at the molecular level, specifically, how it controls protein expression of its targets. Several previous reports have suggested DAZL played important roles as an enhancer of mRNA translation in germ cell development (33)(34)(35).…”
Section: Dazl Is Required For Translation Of Its Targets Mrnas and Inmentioning
confidence: 95%
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“…All animals used were of the C57BL/6J inbred strain. C57BL/6-Zp3cre-Rpl22tm1.1Psam (Zp3-Cre T RiboTag) mice were obtained from Jackson Laboratories and bred as previously described 20 . CPEB1-targeted mice were a gift from Raúl Méndez and colleagues 45 and bred in our laboratory.…”
Section: Animalsmentioning
confidence: 99%
“…DAZL interacts with the 3' UTRs of factors that contribute to multiple stages of 5 spermatogenesis, but it is not clear what transcripts DAZL targets in specific spermatogenic cell types because these targets have been identified in either cultured primordial germ cell-like cells (Chen et al, 2014), ovaries (Rosario et al, 2017), or whole testes containing many stages of spermatogenesis (Chen et al, 2014;Li et al, 2019;Zagore et al, 2018). DAZL functions as a translational enhancer within the oocyte (Collier et al, 2005;Reynolds et al, 2005;Reynolds et 10 al., 2007;Sousa Martins et al, 2016). However, during spermatogenesis, and particularly in spermatogonia, there is conflicting evidence whether DAZL regulates translation (Li et al, 2019;Reynolds et al, 2005;Reynolds et al, 2007) or RNA stability (Zagore et al, 2018).…”
Section: Introductionmentioning
confidence: 99%