DC potentials of the cerebral cortex

Caspers, H.; Speckmann, Erwin‐Josef; Lehmenkühler, A.

doi:10.1007/bfb0027576

Cited by 88 publications

(27 citation statements)

References 99 publications

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“…1996b) also revealed that any strong influences of gross changes in blood gas tension (as derived from end expiratory CO 2 concentration) on sleep‐associated DC potential shifts could be excluded. Although, under extreme conditions of hypo‐ and hypercapnia, DC potential shifts can be readily discerned (Caspers et al . 1987;Rockstroh 1990).…”

Section: Discussionmentioning

confidence: 99%

“…In this context, results of the previous study (Marshall et al, 1996b) also revealed that any strong influences of gross changes in blood gas tension (as derived from end expiratory CO 2 concentration) on sleep-associated DC potential shifts could be excluded. Although, under extreme conditions of hypo-and hypercapnia, DC potential shifts can be readily discerned (Caspers et al, 1987;Rockstroh, 1990). Thus, from the above mentioned, in conjunction with other studies, it can be assumed that the principle source of the DC potential shifts reported here derives from neuronal activity, with a possible contribution of glia cells (e.g.…”

Section: Discussionmentioning

confidence: 99%

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Scalp recorded direct current brain potentials during human sleep

Marshall

Mölle

Fehm

et al. 1998

Eur J of Neuroscience

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The direct current (DC) potential recorded from the scalp of awake humans has been considered a reflection of general changes in cortical excitability. This study examined DC potential shifts in humans during a night of continuous sleep. Standard polysomnographic recordings and skin temperature were measured simultaneously. Contrary to expectations, average DC potential level indicated higher negativity during nonrapid eye movement (NREM) sleep than REM sleep and wakefulness. Moreover, a dynamic regulation of the DC potential level was revealed in association with the NREM-REM sleep cycle comprising four successive phases: (i) a steep 'NREM-transition-negative shift' during the initial 10-15 min of the NREM sleep period; (ii) a more subtle 'NREM-positive slope' during the subsequent NREM sleep period; (iii) a steep 'REM-transition-positive shift' starting shortly prior to the REM sleep period, and (iv) a 'REM-negative slope', characterizing the remaining greater part of the REM sleep period. DC potential changes were only weakly related to changes in slow-wave activity (r2 < 0.18). The NREM-negative slope and REM-positive slope could reflect, respectively, gradually increasing and decreasing cortical excitability resulting from widespread changes in the depolarization of apical dendrites. In contrast, the NREM-transition-negative shift and the REM-transition-positive shift may reflect the progression and retrogression, respectively, of a long-lasting hyperpolarization in deeply lying neurons.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Scalp recorded direct current brain potentials during human sleep

Marshall

Mölle

Fehm

et al. 1998

Eur J of Neuroscience

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“…The positive shift of the DC potential was also mentioned therein. The animal experiments have shown that hypercapnia induces hyperpolarization and the positive DC potential shift [4,32,33].…”

Section: Discussionmentioning

confidence: 99%

“…Numerous works published before the late 1990s implied the neuronal nature of DC potential [3][4][5][6][7][8][9][10]. The negative DC potential shift was considered as a reflection of depolarization processes in the neuroglial complex [4,5,[11][12][13][14][15][16][17]. Such understanding implied that the positive DC potential shift was responsible for re-or hyperpolarization of nervous tissue cells occurring under an active electrode.…”

Section: Introductionmentioning

confidence: 99%

The use of DCEEG to estimate functional and metabolic state of nervous tissue of the brain at hyper- and hypoventilation

Murik¹

2012

WJNS

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A pilot study has been made of the simultaneous DC potential and total slow electrical activity changes during modeling various metabolic and functional states of the human brain. The multi-electrode DCEEG recordings have been performed during the hyperventilation (frequent deep one-minute long breathing motions) and the hypoventilation (voluntary breath holding). It has been shown that the ischemic state occurring in hyperventilation is accompanied by the negative shift of DC potential and increase in the EEG rhythms amplitude. A distention of brain vessels during hypoventilation (voluntary breath-hold) and an improvement of blood supply and thus improvement of vital and functional state of neurons gave rise to an increase in the EEG rhythm amplitude too, though against a background of a positive DC-potential shift. Obtained results are considered with context the generation of the qualitatively different functional states of brain cells during hyper- and hypoventilation which is reflected in their resting potential and activity. The conducted study show the prospects for DCEEG and the method we used for DCEEG data processing to understand the character of functional and metabolic changes in the nervous tissue

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“…From another point of view, the extracellular electromagnetic field surrounding the brain cells is formed by different neurophysiological processes (Buzsáki et al, 2012;Reimann et al, 2013), e.g., synaptic activity (i.e., extracellular dipole current flow from inhibitory to excitatory synapses), changes in ϕm and transmembrane currents of neurons, sodium (Na + ) and calcium (Ca 2+ ) spikes/waves, spike after-hyperpolarizations, ionic/current movements between cells, and membrane potential changes of glial cells. In addition to these cellular sources other sources contribute to the extracellular EM field, i.e., current/ion movements in fluids (e.g., blood, lymph, cerebrospinal fluid, interstitial fluid), activity of brain microvascular smooth muscle and endothelial cells, and changes in the extracellular field potentials across the blood-brain (Tschirgi and Taylor, 1958;Held et al, 1964;Caspers et al, 1987;Revest et al, 1993Revest et al, , 1994Voipio et al, 2002;Mycielska and Djamgoz, 2004;Tétrault et al, 2008;Trivedi et al, 2013).…”

Section: The Possible Physical Mechanism Behind Ephaptic Couplingmentioning

confidence: 99%

Two emerging topics regarding long-range physical signaling in neurosystems: Membrane nanotubes and electromagnetic fields

Scholkmann

2015

J. Integr. Neurosci.

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In this review paper, an overview is given of two emerging research topics that address the importance of long-range physical signaling in living biosystems. The first topic concerns the biophysical principles and the physiological significance of long-range cell-to-cell signaling through electrical signals facilitated by membrane nanotubes (MNTs) (also called "tunneling nanotubes"), namely long membrane extensions that connect cells, discovered about 10 years ago. This review paper looks at experimental results that showed electrical signals being propagated through MNTs, and that MNT-mediated electrical coupling between brain cells involves activation of low-voltage-gated calcium channels. The significance of electrical cell-to-cell coupling through MNT for neuronal communication is discussed. The second topic deals with endogenous electromagnetic fields generated by nerve cells. The review concludes that these fields are not just an "epiphenomenon" but play a fundamental role in neuronal processes. For example, electromagnetic fields from brain cells feed back to their generating cells and to other cells (ephaptic coupling) and, for example, modulate the spiking timing of them. It is also discussed that cell membranes of neurons have specific resonance properties which possibly determine the impact of endogenous electric field fluctuations with respect to field strength and frequency. In addition, it is reviewed how traveling and standing waves of the endogenous electromagnetic field produced by neuronal and non-neuronal cells may play an integral part in global neuronal network dynamics. Finally, an outlook is given on which research questions should be addressed in the future regarding these two topics. Abstract: In this review paper, an overview is given of two emerging research topics that address the importance of longrange physical signaling in living biosystems. The first topic concerns the biophysical principles and the physiological significance of long-range cell-to-cell signaling through electrical signals facilitated by membrane nanotubes (MNTs) (also called "tunneling nanotubes"), namely long membrane extensions that connect cells, discovered about 10 years ago. This review paper looks at experimental results that showed electrical signals being propagated through MNTs, and that MNT-mediated electrical coupling between brain cells involves activation of low-voltage-gated calcium channels. The significance of electrical cell-to-cell coupling through MNT for neuronal communication is discussed. The second topic deals with endogenous electromagnetic fields generated by nerve cells. The review concludes that these fields are not just an "epiphenomenon" but play a fundamental role in neuronal processes. For example, electromagnetic fields from brain cells feed back to their generating cells and to other cells (ephaptic coupling) and, for example, modulate the spiking timing of them. It is also discussed that cell membranes of neurons have specific resonance properties which possibly determin...

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DC potentials of the cerebral cortex

Cited by 88 publications

References 99 publications

Scalp recorded direct current brain potentials during human sleep

Scalp recorded direct current brain potentials during human sleep

The use of DCEEG to estimate functional and metabolic state of nervous tissue of the brain at hyper- and hypoventilation

Two emerging topics regarding long-range physical signaling in neurosystems: Membrane nanotubes and electromagnetic fields

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