DDT and DDE exposure in mothers and time to pregnancy in daughters

Cohn, Barbara A.; Cirillo, Piera M.; Wolff, Mary S.; Schwingl, Pamela J.; Cohen, Richard. D.; Sholtz, Robert I.; Ferrara, Assiamira; Christianson, Roberta E.; Berg, Béa J. van den; Siiteri, Pentti K.

doi:10.1016/s0140-6736(03)13776-2

Cited by 135 publications

(85 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The time interval between exposure to such substances can be very long and early prenatal and postnatal life is probably a critical window for exposure. For instance, a 32% fall in probability of pregnancy was found in daughters of mothers with 10 µg/l of p,p'-DDT in blood drawn at the time of delivery, 30 years earlier (Cohn et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: A review of rodent and human data

Rasier

Toppari

Parent

et al. 2006

Molecular and Cellular Endocrinology

145

108

View full text Add to dashboard Cite

Natural hormones and some synthetic chemicals spread into our surrounding environment share the capacity to interact with hormone action and metabolism. Exposure to such compounds can cause a variety of developmental and reproductive detrimental abnormalities in wildlife species and, potentially, in human. Many experimental and epidemiological data have reported that exposure of the developing fetus or neonate to environmentally relevant concentrations of some among these endocrine disrupters induces morphological, biochemical and/or physiological disorders in brain and reproductive organs, by interfering with the hormone actions. The impact of such exposures on the hypothalamic-pituitary-gonadal axis and subsequent sexual maturation is the subject of the present review. We will highlight epidemiological human studies and the effects of early exposure during gestational, perinatal or postnatal life in female rodents.

show abstract

Section: Discussionmentioning

confidence: 99%

Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: A review of rodent and human data

Rasier

Toppari

Parent

et al. 2006

Molecular and Cellular Endocrinology

145

108

View full text Add to dashboard Cite

show abstract

“…p,p′-DDT, an estrogenic endocrine disrupting chemical, and its anti-androgenic metabolite, p,p′-DDE, have been linked to male reproductive health effects Aneck-Hahn et al, 2006). DDT and/or DDE have also been linked with post generational female reproductive ability (Cohn et al, 2003), urogenital birth defects in neonates (Bornman et al, 2005) and pre-term births (Longnecker et al, 2001). In addition to neurological effects as indicated by the ATSDR (2002), McGlynn et al (2006) also found that high DDT serum levels may be a risk factor for liver cancer.…”

Section: Human Serummentioning

confidence: 99%

DDT contamination from indoor residual spraying for malaria control

Dyk

Bouwman

Barnhoorn

et al. 2010

Science of The Total Environment

110

108

View full text Add to dashboard Cite

a b s t r a c t a r t i c l e i n f oThe insecticide DDT is still used in specific areas of South Africa for indoor residual spray (IRS) to control malaria vectors. Local residents could be exposed to residues of DDT through various pathways including indoor air, dust, soil, food and water. The aims of this study were to determine the levels of DDT contamination, as a result of IRS, in representative homesteads, and to evaluate the possible routes of human exposure. Two villages, exposed (DV) and reference (TV) were selected. Sampling was done two months after the IRS process was completed. Twelve homesteads were selected in DV and nine in TV. Human serum, indoor air, floor dust, outside soil, potable water, leafy vegetables, and chicken samples (muscle, fat and liver) were collected and analyzed for both the o,p′-and p,p′-isomers of DDT, DDD and DDE. DDT was detected in all the media analyzed indicating a combination of potential dietary and non-dietary pathways of uptake. DV had the most samples with detectable levels of DDT and its metabolites, and with the exception of chicken muscle samples, DV also had higher mean levels for all the components analyzed compared to TV. Seventy-nine percent of participants from DV had serum levels of DDT (mean ∑DDT 7.3 μg g −1 lipid). These residues constituted mainly of p,p′-DDD and p,p′-DDE. ∑DDT levels were detected in all indoor air (mean ∑DDT 3900.0 ng m − 3 ) and floor dust (mean ∑DDT 1200.0 μg m − 2 ) samples. Levels were also detected in outside soil (mean ∑DDT 25.0 μg kg − 1 ) and potable water (mean ∑DDT 2.0 μg L − 1 ). Vegetable sample composition (mean ∑DDT 43.0 μg kg − 1 ) constituted mainly p,p′-DDT and p,p′-DDD. Chicken samples were highly contaminated with DDT (muscle mean ∑DDT 700.0 μg kg − 1 , fat mean ∑DDT 240,000.0 μg kg − 1 , liver mean ∑DDT 1600.0 μg kg − 1 ). The results of the current study raise concerns regarding the potential health effects in residents living in the immediate environment following DDT IRS.

show abstract

“…Cocco et al (2005) concluded that the fecundity ratio among spouses of DDT applicators compare to the unexposed was decreased, but the low statistical power of the study did not allow definitive conclusions. Cohn et al (2003) measured serum levels of DDT and DDE in mothers and evaluated TTP in their daughters. Daughters' probability of pregnancy fell by 32% per 10μg/L p,p'-DDT in maternal serum, but increased 16% per 10μg/L p,p'-DDE.…”

Section: Pesticide Exposure and Health Related Issues In Male And Femmentioning

confidence: 99%

Pesticide Exposure and Health Related Issues in Male and Female Reproductive System

Sifakis¹,

Mparmpas²,

Tsatsakis³

2011

Pesticides - Formulations, Effects, Fate

View full text Add to dashboard Cite

DDT and DDE exposure in mothers and time to pregnancy in daughters

Cited by 135 publications

References 9 publications

Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: A review of rodent and human data

Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: A review of rodent and human data

DDT contamination from indoor residual spraying for malaria control

Pesticide Exposure and Health Related Issues in Male and Female Reproductive System

Contact Info

Product

Resources

About