De l’influence du mode de préparation sur le pouvoir acanthogène d’un onguent

Brun, R.; Bujard, E; Jadassohn, W.

doi:10.1159/000256161

Cited by 4 publications

(2 citation statements)

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“…Scattered reports have indicated that petrolatum exerts definite effects in vivo. Application of petrolatum to intact normal skin produces acanthosis (Brun et al, 1956), an observation that was confirmed in our study. Applying petrolatum to a healing wound delayed re-epithelialization (Eaglstein & Mertz, 1979).…”

Section: Discussionsupporting

confidence: 89%

“…The once daily application of petrolatum to normal skin produced acanthosis; this observation confirmed earlier work in human skin (Brun, Bujard & Jadassohn, 1956). On the other hand, application of petrolatum to wound inhibited the hyperplastic response normally observed in untreated wound.…”

Section: The Application Of Petrolatum Daily To Normal and Wounded Skinsupporting

confidence: 89%

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Petrolatum: interference with the oxidation of arachidonic acid

1980

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Microsomal preparations from petrolatum-treated wound skin contained significantly less arachidonic acid-dependent oxidative capacity when compared to activities in untreated wounded skin (t = 6.06, P < 0.001). Microsomes from both untreated and petrolatum-treated wounded skin produced similar quantities of PGE2 and PGF2 alpha; however, microsomal lipoxygenase activity in petrolatum-treated wounded skin was depressed when compared to that in untreated wounded skin. Microsomal preparations from normal pig skin treated with petrolatum oxidized arachidonic acid at a similar rate to those from untreated control skin. Increasing quantities of petrolatum progressively inhibited the synthesis of PGE2 and PGF2 alpha by fetal calf skin microsomes in vitro as determined by both the oxidation of arachidonic acid and the quantification of radioactive product. Topical application of banal compounds that contain lipid substances may therefore alter the cutaneous inflammatory response by local suppression of pathways that generate hydroxy-fatty acids, substances that are known to be chemotactic and pro-inflammatory.

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Section: Discussionsupporting

confidence: 89%

Section: The Application Of Petrolatum Daily To Normal and Wounded Skinsupporting

confidence: 89%