De novo Renal Transplantation after Kaposi Sarcoma: Favorable Outcome in a Patient Receiving Sirolimus and Mycophenolate-Based Immunosuppression

Friedersdorff, Frank; Giessing, Markus; Roller, C.; Baumunk, D.; Değer, Serdar; Budde, Klemens; Liefeldt, Lutz; Hartmann, Vanessa; Fuller, T. Florian

doi:10.1159/000306448

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…Sirolimus (rapamycin), an immunosuppressive drug used in kidney-transplant recipients, probably has antineoplastic effects. The immunosuppressive and antineoplastic effects of sirolimus may be due to a common mechanism [98][99][100][101]. It is thought that sirolimus inhibits not only production of VEGF but also dampens its effects on endothelial cells, and it has been suggested that sirolimus inhibits the progression of Kaposi's sarcoma in kidney-transplant recipients while exerting an antirejection effect on organ allografts [98].…”

Section: Human Herpesvirus 6 Human Herpesvirus 7 and Human Herpesvimentioning

confidence: 99%

Viral Infection in Renal Transplant Recipients

Cukuranovic

Ugrenović

Jovanović

et al. 2012

The Scientific World Journal

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Viruses are among the most common causes of opportunistic infection after transplantation. The risk for viral infection is a function of the specific virus encountered, the intensity of immune suppression used to prevent graft rejection, and other host factors governing susceptibility. Although cytomegalovirus is the most common opportunistic pathogen seen in transplant recipients, numerous other viruses have also affected outcomes. In some cases, preventive measures such as pretransplant screening, prophylactic antiviral therapy, or posttransplant viral monitoring may limit the impact of these infections. Recent advances in laboratory monitoring and antiviral therapy have improved outcomes. Studies of viral latency, reactivation, and the cellular effects of viral infection will provide clues for future strategies in prevention and treatment of viral infections. This paper will summarize the major viral infections seen following transplant and discuss strategies for prevention and management of these potential pathogens.

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Section: Human Herpesvirus 6 Human Herpesvirus 7 and Human Herpesvimentioning

confidence: 99%

Viral Infection in Renal Transplant Recipients

Cukuranovic

Ugrenović

Jovanović

et al. 2012

The Scientific World Journal

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“…Il n'y a aucun élément qui permet d'affirmer que le taux de SKPT est plus élevé avec tel ou tel immunosuppresseur. À l'inverse la prescription de la rapamycine (ou sirolimus) semble présenter un intérêt car plusieurs auteurs ont rapporté des cas d'amélioration ou de régres-sion du SKPT après le remplacement de la ciclosporine ou du tacrolimus par le sirolimus [15,16,17]. Le sirolimus posséde à la fois des propriétés immunosuppressives, anti-tumorales et anti-angiogéniques : c'est donc une drogue particulièrement intéressante chez les patients ayant un risque de SKPT.…”

Section: éTiopathogénie Et Facteurs De Risqueunclassified

“…Si ces patients sont re-transplantés, ils ont un risque non négligeable, mais non quantifiable, de développer un nouveau SKPT, et donc de perdre le deuxième greffon et de retourner en dialyse [41]. Cependant, dans plusieurs cas où il n'y a pas eu de récidive du SKPT après la 2 e greffe [15,42]. Dans le cas rapporté, l'association chirurgie / modification du traitement immunosuppresseur a permis d'obtenir une évo-lution favorable.…”

Section: éVolutionunclassified

Sarcome de Kaposi buccal post-transplantation rénale : présentation d’un cas et revue de la littérature

Hasna

Slama

Sahtout

et al. 2013

Med Buccale Chir Buccale

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Résumé -Abstract -Oral Kaposi sarcoma after renal transplantation: a case report and review of literature. The immunosuppressive therapies are associated with an increase in the risk of Kaposi sarcoma among transplant patients. The management of these tumours is challenging as the immunosuppression must be monitored to prevent a potential transplant rejection. In 2009, a 48-year-old patient was referred to us by the nephrology department for a suspicious palatal lesion. The patient having had a renal transplantation in 2008 was under immunosuppressants. The intra-oral examination revealed a right red-purple palatal swelling, of 2.5 cm in long axis, painless, with firm consistency on palpation. The buccal vestibule was clear. No satellite adenopathy was observed. A biopsy revealed Kaposi sarcoma. An assessment of the local and general extension concluded an absence of an underlying osseous involvement as well as other remote locations. The treatment consisted of a modification of immunosuppressants associated with tumor resection surgery. The loss of mucous substance was repaired by an advanced vestibular flap and rotational palatal flap. The histology confirmed the diagnosis of Kaposi sarcoma and the limits of curative surgery. A 14-month follow-up showed a favorable evolution. Local and regional monitoring did not reveal any recurrence signs; this was confirmed by CTscan follow-up examination. Subsequently, the patient underwent a prosthetic restoration by means of a removable partial denture.

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De novo Renal Transplantation after Kaposi Sarcoma: Favorable Outcome in a Patient Receiving Sirolimus and Mycophenolate-Based Immunosuppression

Cited by 2 publications

References 7 publications

Viral Infection in Renal Transplant Recipients

Viral Infection in Renal Transplant Recipients

Sarcome de Kaposi buccal post-transplantation rénale : présentation d’un cas et revue de la littérature

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