De novo synthesis of trivalent metal complexes with ligand derived from N 1 -[2-(2-Amino-ethylimino)-1-methyl-propylidene]-ethane-1,2-diamine and 4-chloro benzoic acid: spectroscopic validation and in vitro biological studies

Srivastva, Abhay Nanda; Singh, Netra Pal; Shriwastaw, Chandra Kiran

doi:10.1007/s11164-016-2839-6

Cited by 3 publications

(1 citation statement)

References 44 publications

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“…Transition metal complexes of copper metal ions on a variety of ligands have shown promising results on pathogenic Gram positive bacteria such as S. aureus, B. subtilis, E. Faecalis, S. mutans, S. gordonii, B. cereus and Gram-negative bacteria such as E. coli and S. typhi, P. aeruginosa and K. pneumonia, V. cholera and S. pneumonia [17][18][19][20] . The final activities of different transition metal complexes of copper ions are different on tested organisms as it largely depends on either the impermeability of cells of organisms or the difference in the ribosome of bacterial cells as well as on the nature of ligands used to prepare the complexes [38][39][40][41][42][43] . In the present review, we tried to set a view of antibacterial efficacy of copper based metal complexes in front of global researchers to drag their attention for further discoveries and researches to find copper metal complexes as potent antibacterial medicinal agent.…”

Section: Introductionmentioning

confidence: 99%

Anti-bacterial Properties of Transition Metal Complexes of Copper Metal Ion: A Mini Review

Srivastva

Saxena

Singh

et al. 2022

j. of met. mater. res.

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Bacterial infections are a major cause for impulsive deaths in human beings.Bacterial infections of the respiratory, gastrointestinal and central nervoussystem account for the majority of cases of sudden casualties. Readily availabledrugs are getting ineffective by each passing day as the mutation is veryfast in these pathogenic microbes resulting in drug resistance. The growingresistance of bacteria necessitates the development of new and effectivecompounds of desired characteristics that could bar the rapid development ofbacterial cell inside of the host body. Along with cellular resistance for clinicalantibiotics, co-bacterial infections during microbial attacks (viz. virus, fungus,protozoans etc.) also demand for some novel antibacterial drugs having highefficacy and minimal side effects on human body. These antibiotics shouldalso be compatible with remedies ongoing for core microbial infections. So,in demand of search for effective antibacterial moieties, the scope of transitionmetal complexes as drug gives a good signal against the pathogenic bacteriaby inhibiting their growth. The action of metal complexes on bacterial cellmay be due to impremiablity, enzymatic interruptions, ribosomal interactions,disturbance in the path of protein synthesis, denaturing of genetic materialsetc. inside the cell. Metals in complexes may interrupt the lipophilisity throughthe bacterial cell wall. Inclusion of metal ions in organic moieties behavingas ligand delocalize π-electrons upon the entire chelate ring and this chelationresults in overlapping of ligand orbital and partial sharing of (+)ve chargeof metal ion with donor atoms. These structural modifications in metal andorganic lone pair donor species are the supposed reasons for their enhancedantimicrobial activities against pathogenic microbes. The present reviewfocuses on the impact of recently synthesized, well characterized mono andbinuclear transition metal complexes of Cu ions that have the potential to be the drug of the decade in medicinal inorganic chemistry for treating the bacterial diseases.

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Section: Introductionmentioning

confidence: 99%

Anti-bacterial Properties of Transition Metal Complexes of Copper Metal Ion: A Mini Review

Srivastva

Saxena

Singh

et al. 2022

j. of met. mater. res.

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Physicochemical studies on bioactive Cr(III) coordination compounds with esters of hydrazine carboxylic acid as hetero donor ligands

2017

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Bioactive Metal Complexes of Schiff Base Derived from 2,3-Dioxobutane, Ethane-1,2-diamine and 4-Chloro-2-formylphenol: Spectral Studies and in vitro Antimicrobial Activity

Srivastva

Panja²,

Singh

et al. 2021

Asian J. Chem.

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A novel series of trivalent coordination complexes was synthesized by the reaction between a chloride/ acetate salt of iron, chromium, cobalt or manganese ions and NNNNOO type persuasive Schiff base ligand synthesized from 2,3-dioxobutane, ethane-1,2-diamine and 4-chloro-2-formylphenol. Synthesized compounds were characterized by using elemental analysis, molar conductance, magnetic moment, IR, UV-visible, 1H NMR, 13C NMR and ESI-MS spectral analyses. IR and NMR spectra favoured hexadentate coordination behaviour of ligand. Electronic spectra and magnetic moment data reveal Oh geometry with distortion around the metal ion in complexes. The molar conductance values show 1:1 electrolytic nature of complexes. Biological potentiality of the ligand and its metal complexes were tested in vitro against two bacterial and two fungal strains; Bacillus subtilis, Escherichia coli and Aspirgillus niger, Aspirgillus flavus, respectively.

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De novo synthesis of trivalent metal complexes with ligand derived from N 1 -[2-(2-Amino-ethylimino)-1-methyl-propylidene]-ethane-1,2-diamine and 4-chloro benzoic acid: spectroscopic validation and in vitro biological studies

Cited by 3 publications

References 44 publications

Anti-bacterial Properties of Transition Metal Complexes of Copper Metal Ion: A Mini Review

Anti-bacterial Properties of Transition Metal Complexes of Copper Metal Ion: A Mini Review

Physicochemical studies on bioactive Cr(III) coordination compounds with esters of hydrazine carboxylic acid as hetero donor ligands

Bioactive Metal Complexes of Schiff Base Derived from 2,3-Dioxobutane, Ethane-1,2-diamine and 4-Chloro-2-formylphenol: Spectral Studies and in vitro Antimicrobial Activity

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