Deacetylated cellulose acetate nanofibrous dressing loaded with chitosan/propolis nanoparticles for the effective treatment of burn wounds

Sharaf, Sommaya M.; Al-Mofty, Saif El-Din; El-Sayed, El-Sayed M.; Omar, Amina; Dena, Ahmed S. Abo; El‐Sherbiny, Ibrahim M.

doi:10.1016/j.ijbiomac.2021.11.034

Cited by 30 publications

(21 citation statements)

References 50 publications

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“…CS has been used in wound dressings, implant scaffolds, and dental applications [ 128 ]. Cellulose acetate (CA) nanofiber with CS and propolis promotes burned skin repair [ 129 ]. Samprasit et al electrospun CS-based nanofiber mats adhered in the oral cavity to prevent dental caries.…”

Section: Electrospinning In the Treatment Of Oral Ulcersmentioning

confidence: 99%

Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

et al. 2022

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Oral ulcers affect oral and systemic health and have high prevalence in the population. There are significant individual differences in the etiology and extent of the disease among patients. In the treatment of oral ulcers, nanofiber films can control the drug-release rate and enable long-term local administration. Compared to other drug-delivery methods, nanofiber films avoid the disadvantages of frequent administration and certain side effects. Electrospinning is a simple and effective method for preparing nanofiber films. Currently, electrospinning technology has made significant breakthroughs in energy-saving and large-scale production. This paper summarizes the polymers that enable oral mucosal adhesion and the active pharmaceutical ingredients used for oral ulcers. Moreover, the therapeutic effects of currently available electrospun nanofiber films on oral ulcers in animal experiments and clinical trials are investigated. In addition, solvent casting and cross-linking methods can be used in conjunction with electrospinning techniques. Based on the literature, more administration systems with different polymers and loading components can be inspired. These administration systems are expected to have synergistic effects and achieve better therapeutic effects. This not only provides new possibilities for drug-loaded nanofibers but also brings new hope for the treatment of oral ulcers.

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Section: Electrospinning In the Treatment Of Oral Ulcersmentioning

confidence: 99%

Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

et al. 2022

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“…However, no physicochemical implications were explored in this study ( Moradkhannejhad et al, 2018 ). Other materials such as polyurethane, cellulose, chitosan, and silk have also been shown to be compatible with propolis ( Voss et al, 2018 ; Khodabakhshi et al, 2019 ; Khoshnevisan et al, 2019 ; Baygar, 2020 ; Ceylan, 2021 ; Ionescu et al, 2021 ; Sharaf et al, 2021 ). Table 2 summarizes the potential use of propolis in skin/wound dressing-related biomaterials.…”

Section: Skin Dressing-related Biomaterialsmentioning

confidence: 99%

The Suitability of Propolis as a Bioactive Component of Biomaterials

Lesmana

Zulhendri

Fearnley³

et al. 2022

Front. Pharmacol.

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Propolis is a resinous product collected by bees from plant exudates to protect and maintain hive homeostasis. Propolis has been used therapeutically for centuries as folk medicine. Modern research investigating the diversity of the chemical composition and plant sources, biological activity, extraction processes, analytical methods, and therapeutic properties in clinical settings have been carried out extensively since the 1980s. Due to its antimicrobial, anti-inflammatory, and immuno-modulator properties, propolis appears to be a suitable bioactive component to be incorporated into biomaterials. This review article attempts to analyze the potential application of propolis as a biomaterial component from the available experimental evidence. The efficacy and compabitility of propolis depend upon factors, such as types of extracts and types of biomaterials. Generally, propolis appears to be compatible with hydroxyapatite/calcium phosphate-based biomaterials. Propolis enhances the antimicrobial properties of the resulting composite materials while improving the physicochemical properties. Furthermore, propolis is also compatible with wound/skin dressing biomaterials. Propolis improves the wound healing properties of the biomaterials with no negative effects on the physicochemical properties of the composite biomaterials. However, the effect of propolis on the glass-based biomaterials cannot be generalized. Depending on the concentration, types of extract, and geographical sources of the propolis, the effect on the glass biomaterials can either be an improvement or detrimental in terms of mechanical properties such as compressive strength and shear bond strength. In conclusion, two of the more consistent impacts of propolis across these different types of biomaterials are the enhancement of the antimicrobial and the immune-modulator/anti-inflammatory properties resulting from the combination of propolis and the biomaterials.

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“…Bioactive or smart dressings are a class of dressings that are able to deliver bioactive compounds in the wound site and create an active and dynamic interaction with the wound’s environment [ 8 ]. Some formulations incorporating various bioactive molecules (dicarboxylic acids, Ag-nanoparticles, chitosan/propolis nanoparticles) that can prevent infection and have a positive effect on different wound healing phases and accelerate healing have been dealt with in numerous studies [ 1 , 9 , 10 , 11 , 12 ]. The use of dry and solid formulations that allow controlled release of the bioactive component over a longer period can give better therapeutic results because the patient is exposed to a drug concentration that is optimal for treatment [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Curcumin and Diclofenac Therapeutic Efficacy Enhancement Applying Transdermal Hydrogel Polymer Films, Based on Carrageenan, Alginate and Poloxamer

Postolović

Antonijević²,

Ljujić³

et al. 2022

Polymers

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Films based on carrageenan, alginate and poloxamer 407 have been formulated with the main aim to apply prepared formulations in wound healing process. The formulated films were loaded with diclofenac, an anti-inflammatory drug, as well as diclofenac and curcumin, as multipurpose drug, in order to enhance encapsulation and achieve controlled release of these low-bioavailability compounds. The obtained data demonstrated improved drug bioavailability (encapsulation efficiency higher than 90%), with high, cumulative in vitro release percentages (90.10% for diclofenac, 89.85% for curcumin and 95.61% for diclofenac in mixture-incorporated films). The results obtained using theoretical models suggested that curcumin establishes stronger, primarily dispersion interactions with carrier, in comparison with diclofenac. Curcumin and diclofenac-loaded films showed great antibacterial activity against Gram-positive bacteria strains (Bacillus subtilis and Staphylococcus aureus, inhibition zone 16.67 and 13.67 mm, respectively), and in vitro and in vivo studies indicated that curcumin- and diclofenac-incorporated polymer films have great potential, as a new transdermal dressing, to heal wounds, because diclofenac can target the inflammatory phase and reduce pain, whereas curcumin can enhance and promote the wound healing process.

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Deacetylated cellulose acetate nanofibrous dressing loaded with chitosan/propolis nanoparticles for the effective treatment of burn wounds

Cited by 30 publications

References 50 publications

Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

The Suitability of Propolis as a Bioactive Component of Biomaterials

Curcumin and Diclofenac Therapeutic Efficacy Enhancement Applying Transdermal Hydrogel Polymer Films, Based on Carrageenan, Alginate and Poloxamer

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