Deacetylation of chitin oligomers increases virulence in soil-borne fungal pathogens

Gao, Feng; Zhang, Bosen; Zhao, Jinyan; Huang, Jiafeng; Jia, Pei-Song; Wang, Sheng; Zhang, Jie; Zhou, Jian‐Min; Guo, Hui‐Shan

doi:10.1038/s41477-019-0527-4

Cited by 140 publications

(120 citation statements)

References 49 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…Previous studies on plant genomes showed that EDS1 and PAD4 are present in both dicots and monocots, whereas SAG101 is only detected in dicots genomes, which is reminiscent of the NRG1 and TNLs (Collier et al 2011; Wagner et al 2013). Consistent with these findings, recent studies demonstrated that two signaling modules: EDS1–PAD4–ADR1 and EDS1–SAG101–NRG1 that regulate the TNLs‐activated resistance and cell death, respectively (Bhandari et al 2019; Gantner et al 2019; Wu et al 2019). For instance, the cell death mediated by TNL Roq1 after perception of the effector XopQ from X. campestris is dependent on EDS1, SAG101, and NRG1, but not PAD4 that strongly limits bacterial pathogen growth (Qi et al 2018; Gantner et al 2019; Lapin et al 2019).…”

Section: Recent Discoveries Of the Activation Of Intracellular Nlrssupporting

confidence: 61%

“…Consistent with these findings, recent studies demonstrated that two signaling modules: EDS1–PAD4–ADR1 and EDS1–SAG101–NRG1 that regulate the TNLs‐activated resistance and cell death, respectively (Bhandari et al 2019; Gantner et al 2019; Wu et al 2019). For instance, the cell death mediated by TNL Roq1 after perception of the effector XopQ from X. campestris is dependent on EDS1, SAG101, and NRG1, but not PAD4 that strongly limits bacterial pathogen growth (Qi et al 2018; Gantner et al 2019; Lapin et al 2019). Additionally, the AvrRps4‐induced HR is abolished in nrg1a nrg1b mutants, but the growth of bacterial pathogen expressing AvrRps4 effector is increased on adr triple mutants, but not on nrg triple mutants (Wu et al 2019).…”

Section: Recent Discoveries Of the Activation Of Intracellular Nlrssupporting

confidence: 61%

See 1 more Smart Citation

Plant immune signaling: Advancing on two frontiers

Wang

Feng

Zhou

et al. 2020

JIPB

188

144

View full text Add to dashboard Cite

Plants have evolved multiple defense strategies to cope with pathogens, among which plant immune signaling that relies on cell-surface localized and intracellular receptors takes fundamental roles. Exciting breakthroughs were made recently on the signaling mechanisms of pattern recognition receptors (PRRs) and intracellular nucleotide-binding site (NBS) and leucine-rich repeat (LRR) domain receptors (NLRs). This review summarizes the current view of PRRs activation, emphasizing the most recent discoveries about PRRs' dynamic regulation and signaling mechanisms directly leading to downstream molecular events including mitogen-activated protein kinase (MAPK) activation and calcium (Ca 2+ ) burst. Plants also have evolved intracellular NLRs to perceive the presence of specific pathogen effectors and trigger more robust immune responses. We also discuss the current understanding of the mechanisms of NLR activation, which has been greatly advanced by recent breakthroughs including structures of the first full-length plant NLR complex, findings of NLR sensor-helper pairs and novel biochemical activity of Toll/interleukin-1 receptor (TIR) domain.

show abstract

Section: Recent Discoveries Of the Activation Of Intracellular Nlrssupporting

confidence: 61%

Section: Recent Discoveries Of the Activation Of Intracellular Nlrssupporting

confidence: 61%

Plant immune signaling: Advancing on two frontiers

Wang

Feng

Zhou

et al. 2020

JIPB

188

144

View full text Add to dashboard Cite

show abstract

“…Recently, a chitin deacetylase (PDA1) has been found to be required for pathogenicity of Fo f.sp. vasinfectum to cotton (Gao et al, 2019). This provides evidence of a PTI avoidance strategy as de-acetylation of chitin converts it into chitosan, which is a poor inducer of PTI (Gao et al, 2019).…”

Section: De Lamo and Takkenmentioning

confidence: 95%

“…vasinfectum to cotton (Gao et al, 2019). This provides evidence of a PTI avoidance strategy as de-acetylation of chitin converts it into chitosan, which is a poor inducer of PTI (Gao et al, 2019). Another strategy to evade PTI activation is masking fungal MAMPs.…”

Section: De Lamo and Takkenmentioning

confidence: 99%

Biocontrol by Fusarium oxysporum Using Endophyte-Mediated Resistance

2020

View full text Add to dashboard Cite

Interactions between plants and the root-colonizing fungus Fusarium oxysporum (Fo) can be neutral, beneficial, or detrimental for the host. Fo is infamous for its ability to cause wilt, root-, and foot-rot in many plant species, including many agronomically important crops. However, Fo also has another face; as a root endophyte, it can reduce disease caused by vascular pathogens such as Verticillium dahliae and pathogenic Fo strains. Fo also confers protection to root pathogens like Pythium ultimum, but typically not to pathogens attacking above-ground tissues such as Botrytis cinerea or Phytophthora capsici. Endophytes confer biocontrol either directly by interacting with pathogens via mycoparasitism, antibiosis, or by competition for nutrients or root niches, or indirectly by inducing resistance mechanisms in the host. Fo endophytes such as Fo47 and CS-20 differ from Fo pathogens in their effector gene content, host colonization mechanism, location in the plant, and induced host-responses. Whereas endophytic strains trigger localized cell death in the root cortex, and transiently induce immune signaling and papilla formation, these responses are largely suppressed by pathogenic Fo strains. The ability of pathogenic strains to compromise immune signaling and cell death is likely attributable to their host-specific effector repertoire. The lower number of effector genes in endophytes as compared to pathogens provides a means to distinguish them from each other. Coinoculation of a biocontrol-conferring Fo and a pathogenic Fo strain on tomato reduces disease, and although the pathogen still colonizes the xylem vessels this has surprisingly little effect on the xylem sap proteome composition. In this tripartite interaction the accumulation of just two PR proteins, NP24 (a PR-5) and a b-glucanase, was affected. The Fo-induced resistance response in tomato appears to be distinct from induced systemic resistance (ISR) or systemic acquired resistance (SAR), as the phytohormones jasmonate, ethylene, and salicylic acid are not required. In this review, we summarize our molecular understanding of Fo-induced resistance in a model and identify caveats in our knowledge.

show abstract

“…VdPDA1通过去乙酰化酶活性, 改变其几丁质结构, 从而逃避宿主植物对真菌的识别这一全新机制 [244] ; 揭示了大丽轮枝菌分泌蛋白VdSCP41直接操控植物钙调素结合蛋白家族重要免疫转录因子的致病机理 [237] ; 发现大丽轮枝菌胞间效应蛋白VdSSEP1是一个丝氨酸蛋白酶, 该蛋白可抑制几丁质酶Chi28对病原菌细胞壁的降…”

Section: 发现病原真菌免疫逃逸新策略unclassified