Deafness and Vitiligo in an Italian Family

Tosti, Antonella; Bardazzi, Federico; Padova, Maria Pia De; Veronesi, S.; Bergonzoni, C.

doi:10.1159/000249327

Cited by 13 publications

(5 citation statements)

References 2 publications

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“…We cannot confirm a higher frequency of diabetes mellitus, alopecia areata, psoriasis, pernicious anemia and atopic eczema or atopy. We found no eye nor inner-ear involve ment in our active group of patients either, as reported earlier [19,20].…”

Section: Discussionsupporting

confidence: 87%

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Vitiligo and Other Diseases: Coexistence or True Association?

et al. 1994

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In the past, several authors described an association of vitiligo with autoimmune disorders and the presence of different tissue autoantibodies. A review of the literature showed large differences in the results. Therefore, 321 patients with vitiligo (male/female ratio 114/207) were examined to see whether the frequencies of associated diseases and phenomena (i.e. Koebner phenomenon, canities praecox, halo nevi, poliosis circumscripta), the number of pigmented lesions and the presence of autoantibodies are of significance in order to support (a) a subentity of childhood vitiligo and (b) whether there is a true predisposition or association of autoimmune or other diseases in this group of patients. The data confirm earlier results of a prevalence of thyroid disease and the presence of thyroid antibodies, whereas other diseases are a random event. 6.2% of the patients had congenital nevi compared with 2.8% in a normal healthy population. Based on the results of this study and the significant higher risk for development of melanomas in this patient group, an annual checkup is recommended.

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Section: Discussionsupporting

confidence: 87%

“…One hundred eleven randomly chosen patients were examined in the Departments of Ophthalmology and Ear, Nose and Throat, to study the possible involvement of the eyes and the cochlear organ as reported previously [19,20). The ophthalmological workup included a careful slitlamp examination and funduscopy using a contact glass.…”

Section: Methodsmentioning

confidence: 99%

Vitiligo and Other Diseases: Coexistence or True Association?

et al. 1994

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“…A distinct entity with early graying of the hair and congenital deafness is reported as Fisch syndrome 36 , 37 . Autosomal recessive deafness associated with vitiligo has also been reported 83–85 . This association is known as Rozycki syndrome 84 .…”

Section: Differential Diagnosismentioning

confidence: 99%

“…A discriminant analysis revealed that the inner intercanthal distance, philtrum length, lower facial height, and nasal bone length were discriminating parameters of WS type I 30 . WS is caused by a gene alteration, mainly by mutations 13 , 31–92 …”

Section: Clinical Manifestationsmentioning

confidence: 99%

Waardenburg syndrome

Dourmishev¹,

Dourmishev²,

Schwartz³

et al. 1999

Int J Dermatology

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“…Price and Fisher (2001) concur with this view. Furthermore, it has been proposed that the superior resistance to trauma observed in cochleas with greater melanin levels may be due to melanin's ability to scavenge free radicals (Bustamante, Bredeston, Malanga, & Mordoh, 1993;Yamasoba, Schacht, Shoji, & Miller, 1999) and, thus, prevent damage to the hair cells due to environmental toxic agents (Tosti, Bardazzi, De Padova, Veronesi, & Bergonzoni, 1986). In essence, it appears that melanocytes enable the maintenance of proper conditions within the inner ear, conditions that allow the hair cells to live and process sound.…”

Section: Introductionmentioning

confidence: 99%