Deanxit improves anxiety and depression in patients with functional dyspepsia

Guo, Qiu; Peng, Na; Lv, Fei; Jiang, Qi-Hong

doi:10.11569/wcjd.v23.i2.324

Cited by 1 publication

(1 citation statement)

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“…The search strategy generated 432 citations, including eighteen RCTs that investigated the treatment efficacy of antidepressants in FD [ 26 – 43 ]. Ten of these eighteen trials compared antidepressants with placebos, seven compared antidepressants + “conventional treatment” with “conventional treatment” and one compared antidepressants with no treatment.…”

Section: Resultsmentioning

confidence: 99%

Antidepressants in the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis

Chen

Huang

et al. 2016

PLoS ONE

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BackgroundAntidepressants have been empirically used in the treatment of functional dyspepsia (FD). However, results from recent clinical trials investigating their efficacy are conflicting. The aim of this study is to evaluate the efficacy of antidepressants in the management of FD in adults.MethodsDatabases of MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials and BIOSIS Previews were searched for all randomized controlled trials (RCT) investigating efficacy of antidepressants in the management of FD in adult patients. Data of overall symptom unimproved and adverse events were compared between the antidepressants and placebo group.ResultsThe search strategy identified 432 citations. Of those, eight RCTs met the inclusion criteria and were included in the meta-analysis. The pooled relative risk (RR) of symptom unimproved with tricyclic antidepressants (TCAs) versus placebo was 0.76 (95% CI: 0.62 to 0.94, P = 0.01; I2 = 0%, P = 0.39). By contrast, selective serotonin reuptake inhibitors (SSRIs) did not show a benefit over placebo (RR = 1.00, 95% CI: 0.86 to 1.17, P = 0.95; I2 = 0%, P = 0.82). Adverse events were significantly more frequent among patients receiving antidepressants than those receiving placebos (RR = 1.64, 95% CI: 1.14 to 2.35, P = 0.007).ConclusionTCAs but not SSRIs, are effective in the treatment of FD, but antidepressants were also associated with more adverse events compared with placebo.

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Section: Resultsmentioning

confidence: 99%