Drs. Patalay and Demkowicz (2023) offer an impassioned plea for greater attention to be paid to the "gender gap in mental health outcomes" and throw down the gauntlet to the research community to defend its "pervasive disinterest" in this topic. They focus on the gender gap in depressive disorders; the approximately 2 to 1 rate of females to males in prevalence rates, which has been well established (e.g., Hartung & Lefler, 2019). The authors believe that the patriarchal nature of society is ultimately to blame for the alleged scarcity of research on why there is an overrepresentation of females among individuals who suffer from depression.Sex/gender based disparities in health, particularly in risk of disease, but also in disorder course and outcome, and response to treatment are well known, extensively documented, and involve many conditions (given the lack of agreement as to how the words "sex" and "gender" should be defined, I am using both words to account for all possible meanings). For example, women have higher rates of autoimmune diseases while more men than women have Parkinson's disease (Mauvais-Jarvis et al., 2020). Males also predominate over females across all neurodevelopmental conditions such as autism (B€ olte et al., 2023). Reviewers agree that insufficient research attention has been paid in the past to the role of sex/gender in depression (Eid, Gobinath, & Galea, 2019;Hyde & Mezulis, 2020), but also in biomedical (Mazure & Jones, 2015) and general psychopathology research (Hartung & Lefler, 2019), and that many contemporary studies have not implemented the designs and analytic approaches that can help to better understand the importance of sex/gender (Rechlin, Splinter, Hodges, Albert, & Galea, 2022). However, the Article by Drs. Patalay and Demkowicz presents a somewhat inaccurate and polarizing view of the overall state of empirical research on the sex/gender differential in depression prevalence. I list below several salient arguments put forth by Drs. Patalay and Demkowicz (see bulleted and indented text) and my comments.