Deca-Durabolin® and parenteral nutrition in post-traumatic patients

Mosebach, K.-O.; Hausmann, D.; Caspari, R.; Stoeckel, H.

doi:10.1530/acta.0.109s0060

Cited by 10 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Unlike this study, previous studies in critically ill patients did not measure clinical outcome; however, our study was not specifically powered to show a difference in clinical outcome. Also, our metabolic and nutritional findings are in contrast to some reports 4,5,17 and in agreement with others. 18…”

supporting

confidence: 92%

“…4 These results were supported by a prospective, randomized study in patients who received nandrolone 50 mg 3 days after sustaining moderate to severe head injury. 17 Nitrogen balance improved in patients who received intramuscular stanozolol 50 mg 24 hours before colorectal surgery in a prospective, randomized, controlled trial. 5 Nonseptic patients had significant improvements in body weight, lean body mass, and body cell mass when given intramuscular nandrolone 50 mg/week.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Oxandrolone in Trauma Patients

et al. 2000

View full text Add to dashboard Cite

Study Objective. To determine the effect of oxandrolone administration on nutritional and clinical outcomes after multiple trauma. Design. Prospective, randomized, double‐blind, placebo‐controlled study. Setting. Level 1 trauma center in a university teaching hospital. Patients. Sixty‐two patients requiring enteral nutrition, 60 of whom completed the study. Intervention. Patients were randomized to receive either oxandrolone 10 mg or placebo twice/day for a maximum of 28 days. Measurements and Main Results. Total urinary nitrogen, prealbumin, nitrogen balance, total body water, and body cell mass were measured on day 1 of enteral nutrition and then at day 7, day 10, and study exit. Patients were assessed daily for metabolic and infectious complications. The two groups were similar for demographics and dosage of enteral nutrition. Measurement of total urinary nitrogen at study entry showed both groups to be highly catabolic (oxandrolone 17.2 ± 4.9, placebo 19.1 ± 10.8 g/day, NS). On days 7 and 10, total urinary nitrogen increased in both groups; however, there was no significant difference between groups. Nitrogen balance was negative throughout the study in each group. Body cell mass decreased slightly in both groups over the study period. Prealbumin serum concentrations increased significantly in both groups at day 10 and study exit compared with study entry. The groups did not differ significantly for length of hospital stay (oxandrolone 30.8 ± 17.9, placebo 27.0 ± 25.7 days), length of intensive care unit stay (oxandrolone 17.1 ± 7.8, placebo 15.5 ± 9.7 days), and frequency of pneumonia or sepsis (oxandrolone 48, placebo 43 episodes). Conclusion. Oxandrolone 20 mg/day does not have obvious benefit in nutritional and clinical outcomes during the first month after multiple trauma.

show abstract

supporting

confidence: 92%

mentioning

confidence: 99%

Oxandrolone in Trauma Patients

et al. 2000

View full text Add to dashboard Cite

show abstract

“…These agents have been used success fully to promote growth and carcass protein deposition in animal production [2][3][4], and have also been shown to improve nitrogen balance and body protein in human patients suffering from muscle wasting associated with a number of clinical conditions such as acci dental injury [5], surgical trauma [6][7][8] and myotonic dystrophy [9]. However, the mech anisms by which anabolic steroids increase muscle protein content are unclear.…”

Section: Introductionmentioning

confidence: 99%

Dose-Dependent Effects of an Anabolic Steroid, Nandrolone Phenylpropionate (Durabolin), on Body Composition and Muscle Protein Metabolism in Female Rats

1991

View full text Add to dashboard Cite

The effects of three doses (1,4 and 10 mg/kgbody weight) of an anabolic steroid, nandrolone phenylpropionate (NPP), on body weight and composition, and muscle protein metabolism were investigated in female rats. Daily injections of 1 mg/kg of NPP for 10 days caused a significant increase in weight gain which was associated with an increase in body protein (9%) without affecting body fat. At higher doses this effect on body weight was attenuated, resulting in no change in body weight at 10 mg/kg. However body protein content was still increased (9%) whereas body fat content was significantly reduced (32%). NPP did not affect metabolizable energy intake at any dose tested. Body energy gain and gross energetic efficiency were both significantly reduced in animals treated with a dose of 10 mg/ kg. The mass and protein content of gastrocnemius muscle were significantly increased in animals injected with NPP at all doses. Muscle protein synthesis measured in vivo was also significantly stimulated at 1 and 4 mg/kg but was not affected at 10 mg/kg. These data confirm an anabolic action of NPP and suggest highly dose-dependent effects on other parameters such as body weight, fat deposition and muscle protein synthesis.

show abstract

“…Early research in trauma and surgical patients investigating injectable testosterone and testosterone analogs reported increased nitrogen retention and improved nitrogen balances. 50,51 Although positive findings were reported in these studies, clinicians were skeptical about the use of anabolic steroids, especially in women, because of the drugs androgenic complications (edema, lipid abnormalities, and virilizing effects). Additionally, with these early studies, clinical outcome data were not reported.…”

mentioning

confidence: 96%

“…Additionally, with these early studies, clinical outcome data were not reported. 50,51 Hence, the use of injectable anabolic steroids was not overwhelmingly endorsed.…”

mentioning

confidence: 99%