Decelerated vascularization in tissue-engineered constructs in association with diabetes mellitus in vivo

Schumann, Paul; Lindhorst, Daniel; Kampmann, Andreas; Gellrich, Nils‐Claudius; Krone-Wolf, Sonja; Meyer‐Lindenberg, Andrea; See, Constantin von; Gander, Thomas; Lanzer, Martin; Rücker, Martin; Essig, Harald

doi:10.1016/j.jdiacomp.2015.06.004

Cited by 10 publications

(5 citation statements)

References 53 publications

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“…The reduced angiogenic capacity of diabetic mice can be restored with the help of an ingenious scaffold design. The collagen coated scaffold proved an equal capacity of new blood formation in the case of both control and diabetic mice [165].…”

Section: Key Mirnas With Anti-angiogenic Effectsmentioning

confidence: 99%

The Role of Angiogenesis and Pro-Angiogenic Exosomes in Regenerative Dentistry

Zimța

Baru

Badea

et al. 2019

IJMS

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Dental surgeries can result in traumatic wounds that provoke major discomfort and have a high risk of infection. In recent years, density research has taken a keen interest in finding answers to this problem by looking at the latest results made in regenerative medicine and adapting them to the specificities of oral tissue. One of the undertaken directions is the study of angiogenesis as an integrative part of oral tissue regeneration. The stimulation of this process is intended to enhance the local availability of stem cells, oxygen levels, nutrient supply, and evacuation of toxic waste. For a successful stimulation of local angiogenesis, two major cellular components must be considered: the stem cells and the vascular endothelial cells. The exosomes are extracellular vesicles, which mediate the communication between two cell types. In regenerative dentistry, the analysis of exosome miRNA content taps into the extended communication between these cell types with the purpose of improving the regenerative potential of oral tissue. This review analyzes the stem cells available for the dentistry, the molecular cargo of their exosomes, and the possible implications these may have for a future therapeutic induction of angiogenesis in the oral wounds.

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Section: Key Mirnas With Anti-angiogenic Effectsmentioning

confidence: 99%

The Role of Angiogenesis and Pro-Angiogenic Exosomes in Regenerative Dentistry

Zimța

Baru

Badea

et al. 2019

IJMS

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“…Ten week old db/db mice were used in this study. Although older mice might exhibit a more severe vessel impairment, , they are not ideal for wound-healing studies as they display other diabetes-associated complications, such as liver failure, which introduce confounding factors to the wound study. Nevertheless, 10 week old mice exhibit most of the T2D symptoms such as hyperglycemia, obesity, cytokine imbalance, , and accumulation of advanced glycation end products (AGEs), which lead to impaired vascularization and wound healing.…”

Section: Discussionmentioning

confidence: 99%

Poly-Methacrylic Acid Cross-Linked with Collagen Accelerates Diabetic Wound Closure

Coindre

Sefton

2020

ACS Biomater. Sci. Eng.

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Impaired blood vessel formation limits the healing of diabetic ulcers and leaves patients at high risk for amputation. Nonbiologic vascular regenerative materials made of methacrylic acid (MAA) copolymer, such as MAA-co-methyl methacrylate beads, have shown to enhance wound healing in a diabetic animal model, but their lack of biodegradability precludes their clinical implementation. Here, a new MAA-based gel was created by cross-linking polyMAA with collagen using carbodiimide chemistry. Using this gel on full-thickness wounds in diabetic db/db mice augmented vascularization of the wound bed, resulting in a faster closure compared to untreated or collagen-only treated wounds. After 21 days, almost all the wounds were closed and re-epithelialized in the polyMAA-collagen group compared to that in the other groups in which most wounds remained open. Histological and fluorescent gel tracking data suggested that the gel resorbed during the phase of tissue remodeling, likely because of the action of macrophages that colonized the gel. We expect the addition of the polyMAA to commercially available collagen-based dressing to be a good candidate to treat diabetic ulcers.

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“…Although tissue engineering for skin has made many advances, there are still a number of challenges that are present today [62][63][64][65][66]. Limitations arise with vascularization, systemic diseases, and immune rejection, and there is difficulty in regenerating skin appendages [62,[67][68][69][70].…”

Section: Challenges In Skin Tissue Engineeringmentioning

confidence: 99%

Current Biomaterials for Wound Healing

Downer,

Berry,

Parker

et al. 2023

Bioengineering

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Wound healing is the body’s process of injury recovery. Skin healing is divided into four distinct overlapping phases: hemostasis, inflammation, proliferation, and remodeling. Cell-to-cell interactions mediated by both cytokines and chemokines are imperative for the transition between these phases. Patients can face difficulties in the healing process due to the wound being too large, decreased vascularization, infection, or additional burdens of a systemic illness. The field of tissue engineering has been investigating biomaterials as an alternative for skin regeneration. Biomaterials used for wound healing may be natural, synthetic, or a combination of both. Once a specific biomaterial is selected, it acts as a scaffold for skin regeneration. When the scaffold is applied to a wound, it allows for the upregulation of distinct molecular signaling pathways important for skin repair. Although tissue engineering has made great progress, more research is needed in order to support the use of biomaterials for wound healing for clinical translation.

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Decelerated vascularization in tissue-engineered constructs in association with diabetes mellitus in vivo

Cited by 10 publications

References 53 publications

The Role of Angiogenesis and Pro-Angiogenic Exosomes in Regenerative Dentistry

The Role of Angiogenesis and Pro-Angiogenic Exosomes in Regenerative Dentistry

Poly-Methacrylic Acid Cross-Linked with Collagen Accelerates Diabetic Wound Closure

Current Biomaterials for Wound Healing

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