Decellularized cartilage matrix scaffolds with laser-machined micropores for cartilage regeneration and articular cartilage repair

Rabbit thyroid extracellular matrix as a 3D bioscaffold for thyroid bioengineering: a preliminary in vitro study

“…Studies have demonstrated that changes in ECM biomechanical properties occur in varying degrees after decellularization [ 38 ]. Therefore, we purposely evaluated biomechanical properties of the decellularized thyroid gland and from the ECM findings, it was evident that the elastic modulus and toughness properties showed similarity to native thyroid gland tissue, which was similar with others studies [ 39 – 41 ]. As of this, it can be attributed that elastin and collagen content of DTG scaffolds were preserved.…”

Rabbit thyroid extracellular matrix as a 3D bioscaffold for thyroid bioengineering: a preliminary in vitro study

“…[37] Studies have demonstrated that changes in ECM biomechanical properties occur in varying degrees after decellularization. [38] Therefore, we purposely evaluated biomechanical properties of the decellularized thyroid gland and from the ECM ndings, it was evident that the elastic modulus and toughness properties showed similarity to native thyroid gland tissue, which was similar with others studies [39][40][41]. As of this, it can be attributed that elastin and collagen content of DTG scaffolds were preserved.…”

Reproducing the Biomechanical Environment of the Chondrocyte for Cartilage Tissue Engineering

“…The biological response to decellularised cartilage has been extensively shown, using The structural composition of decellularised cartilage, in terms of collagen alignment and composition has been shown to match that of the native tissue (117). However, initially post-decellularisation there is a reduction in GAG content, which translates in increases in deformation (152) and decreases in Youngs moduli under compression compared to native cartilage (157). Despite the reduction from native values, instances where the compressive modulus is measured, values above 1 MPa are reported (163).…”

“…Li et al(157) report that decellularised scaffolds seeded with autologous chondrocytes recover the native Youngs modulus and increase DNA and GAG content with respect to the native controls after 8-weeks of in vivo implantation in a rabbit defect model. Using decellularised cartilage microfilaments, Kang et al (164) created a lyophilised ECM-derived scaffold, showed a similar recovery up to 83% of the stiffness of native cartilage after 6months in vivo implantation.A recent study by Luo et al(117), exemplifies many of the strategies suggested in this review.…”