Decentralised hepatitis C testing and treatment in rural Cambodia: evaluation of a simplified service model integrated in an existing public health system

Zhang, Meiwen; O’Keefe, Daniel; Craig, J; Samley, Keo; Bunreth, Voeurng; Jolivet, Pascal; Balkan, Suna; Marquardt, Tonia; Dousset, Jean‐Philippe; Paih, Mickaël Le

doi:10.1016/s2468-1253(21)00012-1

Cited by 28 publications

(17 citation statements)

References 17 publications

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“…The study led by Médecins Sans Frontières with the Cambodian Ministry of Health addresses this gap in the literature. 6 This study demonstrates the feasibility and effectiveness of a simplified model of HCV care and treatment for the general population integrated into the rural Cambodian public health system.…”

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confidence: 79%

Simplifying hepatitis C service delivery in resource-constrained settings

Tucker

Easterbrook

2021

The Lancet Gastroenterology & Hepatology

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confidence: 79%

Simplifying hepatitis C service delivery in resource-constrained settings

Tucker

Easterbrook

2021

The Lancet Gastroenterology & Hepatology

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“…There have been recommendations made by the professional liver study society and the WHO for countries to simplify the algorithm of hepatitis C diagnostic & treatment [39] , [40] , [41] , [42] , [43] . Simpler and innovative models of care must be established for a scale-up of treatment [44] . Access to affordable diagnostics, capacity building and support for primary care healthcare workers are also critical elements for scaling up hepatitis C management in the community.…”

Section: Strategic Responses-success Of Malaysia and Efforts Made In Chinamentioning

confidence: 99%

What China can learn from Malaysia to achieve the goal of “eliminate hepatitis C as a public health threat” by 2030 – a narrative review

Sun

Cheng

Hassan

et al. 2021

The Lancet Regional Health - Western Pacific

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Background: To discuss a range of strategic options for China to improve the accessibility of direct antiviral agents (DAAs) as the treatment for hepatitis C. Methods: We adopted a narrative review approach for comprehensive comparisons and in-depth analyses of the country context, and barriers of increasing the DAA treatment rate of hepatitis C in Malaysia and China, and how the two countries have been navigating the hepatitis C agenda. Findings: Malaysia adopted a series of successful strategies to scale up the diagnosis of hepatitis C and DAA treatment, which have valuable implications for China. Interpretation: The potential game-changing strategies for China to adapt from Malaysian experiences range from the stepping-up of political commitment and leadership, enhanced market competition, simplified and decentralized treatment at the strengthened primary care level, integrated healthcare services, coordinated government initiatives, to multi-organizational participation and civil society's active role in raising public awareness, and training of non-specialist physicians. Embarking on scale-up of hepatitis C treatment marks another contribution of China to improve the health of not only the Chinese citizens but also mankind, which is an important component for building healthy Chinese and global communities. Funding: No funding supported this study.

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“…However, the substantial out-of-pocket costs for the treatment present an important barrier to service access. For example, patient assistance programs, combined with generic brands of newer hepatitis C treatment, offer a significant cost reduction and widen access to hepatitis C treatment in low- and middle-income countries [ 52 , 53 , 54 ]. Egypt was particularly successful with a national hepatitis C strategy [ 55 ] that provided no-cost DAA-based HCV treatment to more than 2 million people between 2014 and 2017.…”

Section: Intervention Strategies For the Mena Regionmentioning

confidence: 99%

Hepatitis C Virus Infection in Persons Who Inject Drugs in the Middle East and North Africa: Intervention Strategies

Khalsa

Mathur

2021

Viruses

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There is a high incidence and prevalence of hepatitis C viral infection in persons with or without substance use disorders (SUDs) in the Middle East and North Africa (MENA) region, but only a small number receive comprehensive care. Highly effective direct-acting antiviral (DAA) medications are available at substantially lower costs; however, complete elimination of the hepatitis C virus (HCV) can only be achieved if integrated care strategies target those at highest risk for HCV infection and transmission and improve access to care. Due to the high prevalence of SUD in the MENA region, strategies to eliminate HCV must focus on integrated healthcare across multiple subspecialties, including addiction medicine, psychiatry, infectious diseases, hepatology, and social work. In this invited manuscript, we review the epidemiology of HCV in the MENA region and highlight intervention strategies to attain the WHO’s goal of HCV eradication by 2030.

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Decentralised hepatitis C testing and treatment in rural Cambodia: evaluation of a simplified service model integrated in an existing public health system

Cited by 28 publications

References 17 publications

Simplifying hepatitis C service delivery in resource-constrained settings

Simplifying hepatitis C service delivery in resource-constrained settings

What China can learn from Malaysia to achieve the goal of “eliminate hepatitis C as a public health threat” by 2030 – a narrative review

Hepatitis C Virus Infection in Persons Who Inject Drugs in the Middle East and North Africa: Intervention Strategies

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