Hyperledger is considered to be the most mature consortium chain technology. Compared with other blockchain technologies, Hyperledger focuses on the application development of enterprise-level standards. Due to its unique permission management, fine-grained access control, pluggable consensus algorithm and higher transaction performance, Hyperledger has been increasingly used in the hospital information systems. Although there are more and more applications of Hyperledger in the field of health care, there is currently no research to comprehensively classify and compare them. This article obtained the latest 222 articles related to Hyperledger from the of Web of science, Wordlib, and EBSCO databases. And this article used manual method to filter out the literates needed for this review. This article had comprehensively analyzed and compared the above literature, then summarized four research directions related to hospital information systems, including medical drug traceability, medical records, medical images and other medical fields (financial benefits, medical insurance, medical system performance and dynamic processing). Through in-depth analysis of all solutions, this article reconstructed the architecture diagrams of each solution that focus on Hyperledger, and showed the most intuitive comparison results. In addition, we summarized each solution, and analyzed their implementation form four aspects, including traceability, monitoring, security and privacy. Finally, the future opportunities and prospects were discussed. Four potential medical research directions of Hyperledger in DNA research, pathological image sharing, protein folding calculation and machine learning had been identified. Finally, this article discussed the opportunities and prospects for the future of hospital information systems, and summarized the applications of Hyperledger in four potential directions, including DNA research, pathological image sharing, protein folding calculation and machine learning.