Decidualisation: origin and role of associated cells

Tarachand, U.

doi:10.1111/j.1768-322x.1986.tb00459.x

Cited by 25 publications

(6 citation statements)

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“…The factor(s) or mechanism(s) controlling this pregnancy-associated biological process remain(s) elusive. During pregnancy, the uterine endometrium undergoes remarkable cellular changes referred to as decidualization ( 17 ). Cell populations in the decidualized uterine tissue are heterogeneous, including gland epithelial cells, fibroblasts, macrophages, lymphoid cells, and other stromal cells ( 17 ).…”

Section: Resultsmentioning

confidence: 99%

The Involvement of Interleukin (IL)-15 in Regulating the Differentiation of Granulated Metrial Gland Cells in Mouse Pregnant Uterus

Zheng

Young

et al. 1996

The Journal of Experimental Medicine

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Previous studies have suggested that granulated metrial gland (GMG) cells are bone marrow– derived lymphoid cells, which differentiate in situ in the mouse pregnant uterus into natural killer (NK)–like cells. Similar to NK cells, GMG cells express an abundant level of cytolytic mediators such as perforin. The factor(s) regulating the differentiation of GMG cells remain(s) to be identified, although cytokines previously implicated in the stimulation/activation of NK cells (e.g., IL-2, IL-6, IL-7, and IL-12) can be considered as potential candidates. Recently, IL-15, a novel cytokine, which displays biological activities similar to IL-2, has also been shown to be capable of activating NK cells. Using reverse transcription–polymerase chain reaction (RT-PCR) analysis, we have demonstrated in the present study that IL-15 and its cognate receptor, but not the other cytokines, are expressed in the mouse pregnant uterus, with a time course concomitant with those of cytolytic mediators in differentiated GMG cells. Moreover, IL-15, though not IL-2, is capable of inducing the expression of perforin and granzymes in pregnant uterine tissues explanted in vitro. Data obtained from in situ hybridization study have suggested that the macrophages present in the pregnant uterus may be responsible for the production of IL-15. These results suggest that IL-15 is involved in regulating the differentiation of GMG cells during mouse pregnancy.

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Section: Resultsmentioning

confidence: 99%

The Involvement of Interleukin (IL)-15 in Regulating the Differentiation of Granulated Metrial Gland Cells in Mouse Pregnant Uterus

Zheng

Young

et al. 1996

The Journal of Experimental Medicine

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“…Indeed, trophoblast killing by murine and human uterine NK cells has been reported [20]. Other previously proposed functions of granzyme G include (i) the lysis of virus-infected cells present in the uterus and placenta, (ii) the initiation of abortion, (iii) the destruction of the extracellular matrix and cells at the placenta/uterine interface to promote parturition, (iv) nutritive functions, and (v) cytokine production [14,25]. However, there have been no reports of the expression of granzyme G in 2-cell mouse embryos or any conclusive data supporting a particular biological function.…”

Section: Discussionmentioning

confidence: 99%

“…Granzymes D, E, F, and G have also been shown to be expressed at gestation in the mouse uterus during the process of decidualization, in which rapid uterine cell growth and differentiation occurs [13]. The decidual reaction is primarily characterized by the differentiation of stromal fibroblasts into decidual cells and by the proliferation and differentiation of the granulated metrial gland (GMG) cells [14]. Murine GMG cells belong to the natural killer (NK) cell lineage [15-17], and an analogous cell type, the endometrial granulocyte, has been identified in humans [18].…”

Section: Introductionmentioning

confidence: 99%

Granzyme Gis expressed in the two-cell stage mouse embryo and is required for the maternal-zygotic transition

et al. 2010

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BackgroundDetailed knowledge of the molecular and cellular mechanisms that direct spatial and temporal gene expression in pre-implantation embryos is critical for understanding the control of the maternal-zygotic transition and cell differentiation in early embryonic development. In this study, twenty-three clones, expressed at different stages of early mouse development, were identified using differential display reverse transcription polymerase chain reaction (DDRT-PCR). One of these clones, which is expressed in 2-cell stage embryos at 48 hr post-hCG injection, shows a perfect sequence homology to the gene encoding the granzyme G protein. The granzyme family members are serine proteases that are present in the secretory granules of cytolytic T lymphocytes. However, the pattern of granzyme G expression and its function in early mouse embryos are entirely unknown.ResultsUpon the introduction of an antisense morpholino (2 mM) against granzyme G to knock-down endogenous gene function, all embryos were arrested at the 2- to 4-cell stages of egg cleavage, and the de novo synthesis of zygotic RNAs was decreased. The embryonic survival rate was dramatically decreased at the late 2-cell stage when serine protease-specific inhibitors, 0.1 mM 3,4-dichloroisocoumarin (3,4-DCI), and 2 mM phenyl methanesulphonyl fluoride (PMSF), were added to the in vitro embryonic culture medium. Survival was not affected by the addition of 0.5 mM EDTA, a metalloproteinase inhibitor.ConclusionWe characterized for the first time the expression and function of granzyme G during early stage embryogenesis. Our data suggest that granzyme G is an important factor in early mouse embryonic development and may play a novel role in the elimination of maternal proteins and the triggering of zygotic gene expression during the maternal-zygotic transition.

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“…Pijnenborg et al [16] used the term endometrial granulocyte for this cell type, which appeared to be confined to the endometrium. These cells are equivalent to the metrial gland cells of rodents for which an abundant literature exists [18]. There is now general agreement that these cells are derived from the bone marrow, rather than from stromal stem cells, as had been assumed by Dallenbach-Hellweg [17].…”

Section: Discussionmentioning

confidence: 95%

Imbalance of mononuclear cell infiltrates in the placental tissue from foetuses after spontaneous abortion versus therapeutic termination from 8th to 12th weeks of gestational age

Lambropoulou

Tamiolakis²,

Venizelos

et al. 2006

Clin. Exper.Med.

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Placental macrophages (Hofbauer cells) are located close to trophoblastic cells and foetal capillaries, which make them perfect candidates for involvement in regulatory processes within the villous core. Their capacity of producing several cytokines and prostaglandin-synthesising enzymes, and expressing vascular endothelial growth factor, indicate a possible role in placental development and angiogenesis in order to support pregnancy. Common cells to Hofbauer macrophages sharing similar cell surface markers (HLA-A, -B, -C and leukocyte common antigen) have been reported in the stroma, decidua and amnion, indicating additional foetal protection. Yet this is not always the case. Most spontaneous abortions occur before 12 weeks' gestation, and most are due to chromosomal errors in the conceptus. Relatively few truly spontaneous abortions take place between 12 and 20 weeks' gestation. Thereafter, between 20 and 30 weeks, another type of premature spontaneous termination becomes prevalent, which is due to ascending infection. The numbers of cells expressing the various markers of the monocytemacrophage lineage change throughout pregnancy. In the present study, we investigated the immunohistochemical expression of mononuclear infiltrations in paraffin-embedded placentas, from foetuses after spontaneous abortion (8th, 10th and 12th weeks of gestational age), and those after therapeutic abortion at the same time, using a panel of monoclonal antibodies for the identification of leukocytes (CD45/LCA), B-lymphocytes (CD20/L-26), T lymphocytes (CD45RO/UCHL1), CD68 and CD14 cells. Immunologic factors in human reproductive failure are plausible mechanisms of infertility and spontaneous abortion. Approximately 25% of cases of premature ovarian failure appear to result from an autoimmune aetiology. Unfortunately, current therapeutic options for these women are limited to exogenous hormone or gamete substitution. Local inflammations at the sites of endometriosis implants are postulated to mediate the pain and reduced fecundability associated with this clinical syndrome. The recruitment of immune cells, particularly monocytes and T-cells, neovascularisation around foci of invading peritoneal lesions, and the possible development of antiendometrial autoantibodies support an immunologic basis of this disorder. To date, treatment of pain and infertility associated with endometriosis is primarily surgical, although immune-based adjuvants are theoretical possibilities for the future. Finally, although hypotheses supporting immunologic mechanisms of recurrent pregnancy loss have been popular over the past decade, most clinical investigations in this area do not provide compelling evidence for this position. Reputable specialists in reproductive medicine use experimental immunotherapies judiciously in selected cases of repetitive abortion. For example, the use of anticoagulation therapy can be beneficial in cases with documented antiphospholipid antibodies. At present, however, efficacious immunotherapy protocols for general application ...

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Decidualisation: origin and role of associated cells

Cited by 25 publications

References 0 publications

The Involvement of Interleukin (IL)-15 in Regulating the Differentiation of Granulated Metrial Gland Cells in Mouse Pregnant Uterus

The Involvement of Interleukin (IL)-15 in Regulating the Differentiation of Granulated Metrial Gland Cells in Mouse Pregnant Uterus

Granzyme Gis expressed in the two-cell stage mouse embryo and is required for the maternal-zygotic transition

Imbalance of mononuclear cell infiltrates in the placental tissue from foetuses after spontaneous abortion versus therapeutic termination from 8th to 12th weeks of gestational age

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