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Proliferation of peri- and subluminal stroma following a stimulus from the blastocyst leads to the appearance of decidual cells in the mammalian endometrium. Decidualisation can also be elicited by artificial stimuli in pseudopregnant animals. A variety of histophysiological reactions accompany decidualisation and distinct morphological features characterize decidual cells localized in the antimesometrial and mesometrial area. Granulated metrial gland cells, arising in the endometrium of decidualising uterus, form a separate class of cells and become prominent in the mesometrial triangle as pregnancy advances. This review deals with factors related to induction of decidualisation; structural characteristics of decidual and metrial gland cells; the origin and postulated roles of decidualisation-associated cells. The functional role of decidual and metrial gland cells is discussed in relation to their structural complexity and recent observations on the haemopoietic origin of these cells.

Accumulation of oxalate leads to hyperoxaluria and calcium oxalate nephrolithiasis in man. Since oxalate is a metabolic end product in mammals, the feasibility of its enzymic degradation has been tested in vivo in rats by administering exogenous oxalate oxidase. Oxalate oxidase, isolated from banana fruit peels, in its native form was found to be non-active at the physiological pH of the recipient animal. However, its functional viability in the recipient animal was ensured by its prior binding with ethylenemaleic anhydride, thus shifting its pH activity curve towards the alkaline range. Rats implanted with dialysis membrane capsules containing such immobilized oxalate oxidase in their peritoneal cavities effectively metabolized intraperitoneally injected [Yloxalate as well as its precursor [Wlglyoxalate.The implantation of capsules containing coentrapped multienzyme preparations of oxalate oxidase, catalase and peroxidase led to a further degradation of administered [Wloxalate in rats. Oxalate oxidase Nephrolithiasis

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