Gestation confers temporary resistance to peroxidation in the maternal rat brain

Subramanian, M. S.; Pusphendran, C.K.; Tarachand, U.; Devasagayam, T.P.A.

doi:10.1016/0304-3940(93)90695-h

Cited by 34 publications

(13 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This anti-oxidative stress effect is achieved by upregulating antioxidant enzymes, such as superoxide dismutase (SOD) 30 , and by increasing the levels of mitochondrial glutathione, a critical free radical scavenger 31 . Reducing the presence of reactive oxygen and nitrogen species can help maintain membrane integrity and help stabilize the blood-brain barrier (BBB), which in turn improves cell survival following brain injury.…”

Section: Mechanisms Underlying Prog's Neuroprotective Effectsmentioning

confidence: 99%

The neuroprotective effects of progesterone on traumatic brain injury: current status and future prospects

Wei

Gao

2013

Acta Pharmacol Sin

View full text Add to dashboard Cite

Traumatic brain injury is the leading cause of morbidity and mortality in young adults. The secondary injury in traumatic brain injury consists of a complex cascade of processes that simultaneously react to the primary injury to the brain. This cascade has been the target of numerous therapeutic agents investigated over the last 30 years, but no neuroprotective treatment option is currently available that improve neurological outcome after traumatic brain injury. Progesterone has long been considered merely a female reproductive hormone. Numerous studies, however, show that progesterone has substantial pleiotropic properties as a neuroprotective agent in both animal models and humans. Here, we review the increasing evidence that progesterone can act as a neuroprotective agent to treat traumatic brain injury and the mechanisms underlying these effects. Additionally, we discuss the current progress of clinical studies on the application of progesterone in the treatment of traumatic brain injuries.

show abstract

Section: Mechanisms Underlying Prog's Neuroprotective Effectsmentioning

confidence: 99%

The neuroprotective effects of progesterone on traumatic brain injury: current status and future prospects

Wei

Gao

2013

Acta Pharmacol Sin

View full text Add to dashboard Cite

show abstract

Section: Do Progesterone or Its Metabolites Enhance Recovery After Inmentioning

confidence: 99%

“…Although progesterone does not have the characteristic structure of an antioxidant, high endogenous levels of, or exogenous treatments with, this hormone are effective in reducing free radical damage 56‐59. Pregnancy itself can reduce lipid peroxidation in brain homogenates and mitochondria as measured by the thiobarbituric acid method 56‐59. Progesterone administration reduces lipid peroxidation in three different types of in vitro free radical‐generating systems in a dose‐dependent manner58,59 and increases levels of mitochondrial glutathione, a critical free‐radical scavenger enzyme 58.…”

Section: Do Progesterone or Its Metabolites Enhance Recovery After Inmentioning

confidence: 99%

The Case for Progesterone

Stein

2005

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Recent clinical trials in hormone therapy (HT) for women approaching or past menopause have been disappointing. Most women who have been taking conjugated equine estrogens combined with synthetic progestins have been encouraged to stop these supplements because of increased health risks. The results of the clinical trials may be accurate about the risks associated with the synthetic compounds and combinations, but the data do not reflect what might have been the case if 17beta-estradiol had been tested with natural progesterone instead of synthetic medroxyprogesterone acetate. For the most part, in almost all work on HT, estrogens have been given the primary focus despite the fact that progesterone has important properties that can enhance the repair of neurodegenerative and traumatic injuries to the central nervous system. This article reviews some of those properties and discusses the evidence suggesting that, if HT is to be reconsidered, progesterone should be given more attention as a potent neurotrophic agent that may play an important role in reducing or preventing motor, cognitive, and sensory impairments that can accompany senescence in both males and females.

show abstract

“…In fact, ethanol has been demonstrated to induce a dose-dependent increase in lipid peroxidation in brain homogenates (Montoliu et al, 1994) and gestation to confer temporary resistance to peroxidation in the maternal rat brain (Subramanian et al, 1993). This protective effect of gestation could be responsible for the decreased toxic effects of ethanol on brain membrane alterations observed after chronic ethanol intake.…”

Section: Discussionmentioning

confidence: 98%

Differential effects of ethanol ingestion on somatostatin content, somatostatin receptors and adenylyl cyclase activity in the frontoparietal cortex of virgin and parturient rats

et al. 2005

View full text Add to dashboard Cite

Chronic ethanol ingestion decreases the number of somatostatin (SRIF) receptors in the rat frontoparietal cortex and female sex hormones modulate the effects of ethanol in the brain. Therefore, we investigated the differential effects of ethanol consumption on the SRIFergic system in the frontoparietal cortex of virgin and parturient rats given ethanol in their drinking water before and during gestation. In parturient rats, ethanol consumption decreased the density of SRIF receptors (25%, p b 0.01 vs control parturient group) whereas the SRIF-like immunoreactivity (SRIF-LI) content was increased (140%, p b 0.01). In virgin rats, ethanol ingestion decreased the density of SRIF receptors (42%, p b 0.01) more than in alcoholic parturient rats. SRIF-LI levels were unaffected. The inhibitory effect of SRIF on basal and forskolin-stimulated adenylyl cyclase was significantly lower in alcoholic virgin rats as compared to alcoholic parturient rats. No differences in the levels of the G inhibitory (Gi) a1 and Gia2 proteins were observed among the experimental groups. These results suggest that gestation may confer partial resistance to the ethanol-induced effect on the SRIFergic system. D

show abstract

Gestation confers temporary resistance to peroxidation in the maternal rat brain

Cited by 34 publications

References 22 publications

The neuroprotective effects of progesterone on traumatic brain injury: current status and future prospects

The neuroprotective effects of progesterone on traumatic brain injury: current status and future prospects

The Case for Progesterone

Differential effects of ethanol ingestion on somatostatin content, somatostatin receptors and adenylyl cyclase activity in the frontoparietal cortex of virgin and parturient rats

Contact Info

Product

Resources

About