Decreased lipid peroxidation in the rat kidney during gestation

Devasagayam, T.P.A.; Tarachand, U.

doi:10.1016/0006-291x(87)91297-6

Cited by 277 publications

(133 citation statements)

References 16 publications

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“…As it is known, AA-induced lipid peroxidation is a non-enzymatic reaction involving ferro iron and ascorbate, but enzymatic NADPH-induced lipid peroxidation is known to be mediated by the enzyme NADPH cytochrome c reductase and requires ferric iron chelated with ADP (23,33). Both types of lipid peroxidation show peroxidation potential of tissues and are con- Table 2.…”

Section: Discussionmentioning

confidence: 99%

Lipid Peroxidation Potential and Antioxidants in the Heart Tissue of .BETA.-Alanine- or Taurine-Treated Old Rats

Parildar

Doğru‐Abbasoğlu

Mehmetçik

et al. 2008

J Nutr Sci Vitaminol

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SummaryThe aim of this study was to investigate the effect of the changes of taurine levels in the hearts of old rats on endogenous malondialdehyde (MDA) and diene conjugate (DC) levels and ascorbic acid (AA)-and NADPH-induced lipid peroxidation as well as nonenzymatic (glutathione, vitamin E and vitamin C) and enzymatic antioxidants (superoxide dismutase, glutathione peroxidase and glutathione transferase). Two groups of old (22 mo) rats were treated with ␤ -alanine (3%, w/v; in drinking water), a taurine depleting agent, or taurine (2% w/v; in drinking water) for 6 wk. Significant decreases were observed in taurine contents of hearts in old rats as compared to young (5 mo) rats. We found that MDA and DC levels and AA-and NADPH-induced lipid peroxidation increased, but non-enzymatic and enzymatic antioxidants did not alter in heart homogenates of aged rats. ␤ -Alanine administration resulted in significant decreases in heart taurine levels of old rats. This treatment did not cause further increases in MDA or DC levels or changes in antioxidants. However, AAand NADPH-induced lipid peroxidation was higher than that of old rats. Taurine treatment caused significant increases in heart taurine levels of old rats. This treatment was found to decrease endogenous MDA and DC levels without affecting the antioxidant system in the heart homogenates of aged rats. AA-and NADPH-induced lipid peroxidation was also reduced in old rats when given taurine, although not statistically significantly. Our results indicate that the changes in heart taurine levels may influence the susceptibility of heart tissue to lipid peroxidation in aged rats and that taurine supplementation has protective effects on age-dependent oxidative stress in heart tissue.

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Section: Discussionmentioning

confidence: 99%

Lipid Peroxidation Potential and Antioxidants in the Heart Tissue of .BETA.-Alanine- or Taurine-Treated Old Rats

Parildar

Doğru‐Abbasoğlu

Mehmetçik

et al. 2008

J Nutr Sci Vitaminol

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“…Lipid peroxidation (LPO) was measured by the method Devasagayam and Tarachand [27]. The results were expressed as nanomoles of MDA formed per milligram protein.…”

Section: Reactive Oxygen Speciesmentioning

confidence: 99%

Gestational Cadmium Exposure-Induced Ovotoxicity Delays Puberty through Oxidative Stress and Impaired Steroid Hormone Levels

Samuel¹,

Stanley

Princess³

et al. 2011

J. Med. Toxicol.

104

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Cadmium (Cd), an environmental pollutant, has been shown to be highly toxic to both humans and animals. Its widespread industrial use has led to its accumulation in the environment. Cd has been shown to target multiple organs following acute intoxication, causing nephrotoxicity, immunotoxicity, osteotoxicity, and reproductive toxicity. Cd can cross the placental barrier and cause a wide range of defects during fetal development. The current study was aimed to assess the effect of Cd on the female reproductive system. Female rats were exposed to Cd [50/200 ppm] from embryonic day 9 to 21 through drinking water. Serum steroid hormone concentrations, hematological parameters, antioxidant enzyme levels, and ovarian histopathology were described. Water consumption, gravid uterine/body weight decreased in both the doses of Cd-treated dams. The hematological parameters analyzed in rat pups showed a significant reduction in both doses of Cd studied, while hemoglobin showed a significant reduction in 200 ppm Cd treatment alone. MCHC levels did not show any variation in 50 ppm Cd treatment, while 200 ppm Cd treatment significantly increased. Specific activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, and serum testosterone, estradiol, and progesterone were significantly decreased. The levels of hydrogen peroxide and lipid peroxidation were increased in 50 and 200 ppm Cd-treated rats. These changes were accompanied with disrupted ovarian histoarchitecture, an extended estrous cycle, and delayed pubertal onset in Cd-treated rats. The data generated from the present study suggest that gestational Cd treatment induces ovarian toxicity and reproductive dysfunction through increased oxidative stress.

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“…Hepatoprotective and Antioxidant Effect of Pisonia aculeata L. against … 207 as lipid peroxidation (LPO) [11], superoxide dismutase (SOD) [12], Catalase [13], glutathione peroxidase (GPx) [14], and glutathione S-transferase (GST) [15]. A portion of liver was fixed in 10% formalin for histopathological studies.…”

Section: Assessment Of Liver Functionmentioning

confidence: 99%

Hepatoprotective and Antioxidant Effect of Pisonia aculeata L. against CCl4-Induced Hepatic Damage in Rats

Palanivel¹,

Balasubramanian²,

Kumar³

et al. 2008

Sci Pharm

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Ethanol extract of Pisonia aculeata (EPA) was evaluated for hepatoprotective and antioxidant activities in rats. The plant extract (250 and 500 mg/kg, p.o.) showed a remarkable hepatoprotective and antioxidant activity against carbon tetrachloride (CCl 4) -induced hepatotoxicity as judged from the serum marker enzymes and antioxidant levels in were compared with respective control. Results indicate the hepatoprotective and antioxidant properties of P. aculeata against CCl 4 -induced hepatotoxicity in rats.

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Decreased lipid peroxidation in the rat kidney during gestation

Cited by 277 publications

References 16 publications

Lipid Peroxidation Potential and Antioxidants in the Heart Tissue of .BETA.-Alanine- or Taurine-Treated Old Rats

Lipid Peroxidation Potential and Antioxidants in the Heart Tissue of .BETA.-Alanine- or Taurine-Treated Old Rats

Gestational Cadmium Exposure-Induced Ovotoxicity Delays Puberty through Oxidative Stress and Impaired Steroid Hormone Levels

Hepatoprotective and Antioxidant Effect of Pisonia aculeata L. against CCl4-Induced Hepatic Damage in Rats

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