Deciphering the enigmatic crosstalk between prostate cancer and Alzheimer's disease: A current update on molecular mechanisms and combination therapy

Poddar, Nitesh Kumar; Agarwal, Disha; Agarwal, Yamini; Wijayasinghe, Yasanandana Supunsiri; Mukherjee, Arunima; Khan, Shahanavaj

doi:10.1016/j.bbadis.2022.166524

Cited by 5 publications

(2 citation statements)

References 197 publications

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“…Recent research has unveiled a reciprocal negative correlation between Alzheimer’s disease and cancer incidence. Studies have indicated that individuals with AD have their cancer risk halved, while a 35% decrease in the likelihood of AD has been noted among individuals who have had or recovered from cancer ( 9 , 10 ). Prior observational research has suggested that those afflicted with AD may have a diminished probability of developing prostate cancer ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Causal relationship between Alzheimer’s disease and prostate cancer: a bidirectional Mendelian randomization analysis

Li,

Peng,

Deng

et al. 2024

Front. Endocrinol.

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BackgroundPrevious observational researchers have found an inverse bidirectional link between Alzheimer’s disease (AD) and prostate cancer (PCa); yet, the causative nature of this link remains unclear. To investigate the causal interactions between AD and PCa, a bidirectional Mendelian randomization (MR) analysis was conducted.MethodsThis study comprised two Genome-Wide Association Study (GWAS) summary statistics for AD (17,008 cases and 37,154 controls) and PCa (79,148 cases and 61,106 controls) in individuals of European ancestry. The inverse-variance weighted (IVW) method was employed as the primary approach, while MR-Egger, weighted median, weighted mode, and simple mode served as supplementary methods for estimating the causal effect. To assess pleiotropy, the MR-PRESSO global test and MR-Egger regression were used. Cochran’s Q test was adopted to check heterogeneity, MR Steiger test and the leave-one-out analysis was performed to confirm the robustness and reliability of the results.ResultsThe causal association genetically inferred of AD on PCa was found using IVW (OR = 0.974, 95% CI = 0.958-0.991, p = 0.003) in forward MR analysis and the causal association genetically inferred of PCa on AD was not found using IVW (OR = 1.000, 95% CI: 0.954-1.049, P = 0.988) in reverse MR analysis. The sensitivity analysis showed that no pleiotropy and heterogeneity was observed. The leave-one-out analysis showed that the findings were not inordinately affected by any instrumental variables.ConclusionThe results of this study demonstrated an absence of bidirectional causality between AD and PCa among the European population, suggested that a genetically predicted possibility of decreased PCa risk in AD patients, and no significant genetically predicted causal effect of PCa on AD.

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Section: Introductionmentioning

confidence: 99%

Causal relationship between Alzheimer’s disease and prostate cancer: a bidirectional Mendelian randomization analysis

Li,

Peng,

Deng

et al. 2024

Front. Endocrinol.

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“…At present, the drugs for the clinical treatment of LMI can not significantly effectively prevent and delay the progress of LMI, and there are some problems in the clinical application of the drugs, such as low therapeutic effect and more adverse reactions [2] . A variety of proteins, such as serine/threonine protein kinases, inflammation-and immune-related proteins, may be potential targets for the treatment of nervous system diseases [3][4][5] . Traditional Chinese medicine has a significant effect on the symptom relief and course delay of LMI, with the advantages of less adverse reactions and high effectiveness, so the molecular mechanism-related research on the intervention with traditional Chinese medicine in LMI has become increasingly active [6] .…”

Section: Introductionmentioning

confidence: 99%

Screening of active components of Ganoderma lucidum and decipher its molecular mechanism to improve learning and memory disorders

Zhang,

Ji,

et al. 2024

Bioscience Reports

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Learning and memory impairment (LMI), a common degenerative central nervous system disease. Recently, more and more studies have shown that Ganoderma lucidum (GL) can improve the symptoms of LMI. The active ingredients in GL and their corresponding targets were screened through TCMSP (Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform) and BATMAN-TCM (Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine) databases, and the potential LMI targets were searched for through GeneCard (GeneCards Human Gene Database) and DrugBank. Then, we construct a "main active ingredient-target" network and a protein-protein interaction (PPI) network diagram.The GO (Gene Ontology) functional enrichment analysis and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway annotation analysis were performed on the common targets through DAVID (Database for Annotation Visualization and Integrated Discovery) to clarify the potential molecular mechanism of action of active ingredients in GL. The TNF protein was verified by western blot;Twenty one active ingredients in GL and 142 corresponding targets were screened out, including 59 targets shared with LMI. The 448 biological processes shown by the GO functional annotation results and 55 signal pathways shown by KEGG enrichment analysis were related to the improvement of LMI by GL, among which the correlation of Alzheimer disease pathway is the highest, and TNF was the most important protein; TNF can improve LMI.GL can improve LMI mainly by 10 active ingredients in it, and they may play a role by regulating Alzheimer disease pathway and TNF protein.

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Association of mTOR Pathway and Conformational Alterations in C-Reactive Protein in Neurodegenerative Diseases and Infections

Poddar,

Khan,

Fatima

et al. 2023

Cell Mol Neurobiol

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Deciphering the enigmatic crosstalk between prostate cancer and Alzheimer's disease: A current update on molecular mechanisms and combination therapy

Cited by 5 publications

References 197 publications

Causal relationship between Alzheimer’s disease and prostate cancer: a bidirectional Mendelian randomization analysis

Causal relationship between Alzheimer’s disease and prostate cancer: a bidirectional Mendelian randomization analysis

Screening of active components of Ganoderma lucidum and decipher its molecular mechanism to improve learning and memory disorders

Association of mTOR Pathway and Conformational Alterations in C-Reactive Protein in Neurodegenerative Diseases and Infections

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