Deciphering the Formulation Secret Underlying Chinese Huo-Clearing Herbal Drink

Wang, Jianan; Zhou, Bo; Hu, Xiangdong; Dong, Shuang-Lin; Hong, Ming; Wang, Jun; Chen, Jian; Zhang, Jiu‐liang; Zhang, Qiyun; Li, Xiaohua; Shikov, Alexander N.; Hu, Sheng; Hu, Xuebo

doi:10.3389/fphar.2021.654699

Cited by 6 publications

(7 citation statements)

References 27 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, this principle is difficult to follow in practice, due to the multiple symptoms of diseases and polyfunctionality of medicinal plants. Therefore, many formulas of TCM contain secrets that are not always explained by rationality ( Wang et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Medical Species Used in Russia for the Management of Diabetes and Related Disorders

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background: Polyherbal mixtures called “medical species” are part of traditional and officinal medicine in Russia. This review aimed to analyze medical species used in Russia for the treatment of diabetes and related disorders. The information relevant to medical species, diabetes, and obesity was collected from local libraries, the online service E-library.ru, and Google Scholar. The prediction of the antidiabetic activity for the principal compounds identified in plants was performed using the free web resource PASS Online.Results: We collected and analyzed information about the compositions, specificities of use, and posology of 227 medical species. The medical species represent mixtures of 2–15 plants, while the most frequently mentioned in the literature are species comprising 3–6 plants. The top 10 plants among the 158 mentioned in the literature include Vaccinium myrtillus L., Phaseolus vulgaris L., Taraxacum campylodes G.E. Haglund., Urtica dioica L., Rosa spp., Hypericum spp., Galega officinalis L., Mentha × piperita L., Arctium spp, and Fragaria vesca L. The leading binary combination found in medical species comprises the leaves of V. myrtillus and pericarp of P. vulgaris; leaves of V. myrtillus and leaves of U. dioica; and leaves of V. myrtillus and aerial parts of G. officinalis. In triple combinations, in addition to the above-mentioned components, the roots of T. campylodes are often used. These combinations can be regarded as basic mixtures. Other plants are added to improve the efficacy, treat associated disorders, improve gastrointestinal function, prevent allergic reactions, etc. Meanwhile, an increase in plants in the mixture necessitates advanced techniques for quality control. A feature of medical species in Russia is the addition of fresh juices, birch sap, seaweeds, and adaptogenic plants. Modern studies of the mechanisms of action and predicted activities of the principal compounds from medicinal plants support the rationality of polyherbal mixtures. Nevertheless, the mechanisms are not well studied and reported due to the limited number of compounds. Further investigations with calculations of synergistic or additive indices are important for strengthening the scientific fundamentals for the wider use of medical species in the therapy of diabetes. Two medical species, “Arfazetin” (7 medicinal plants) and “Myrphasinum” (12 medicinal plants), are approved for use in officinal medicine. The efficacy of these species was confirmed in several in vivo experiments and clinical trials. According to modern regulatory rules, additional experiments and clinical trials are required for more detailed investigations of the mechanisms of action and confirmation of efficacy.Conclusion: We believe that the scientifically based utilization of rich plant resources and knowledge of Russian herbal medicine can significantly contribute to the local economy as well as to the sectors seeking natural healing products.

show abstract

Section: Resultsmentioning

confidence: 99%

Medical Species Used in Russia for the Management of Diabetes and Related Disorders

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition, in vitro studies have indicated that licorice was effective in combination with other herbs could decrease a few classical cytokines including TNF-α, IL-1β, MCP-1, and IFN. The levels of cytokines were back to normal, indicating that licorice composed with other herbs helps reduce the inflammatory level (Wang et al, 2021).…”

Section: Anti-inflammatory Effectsmentioning

confidence: 98%

“…Beyond that, E channel was also found to participate in MERS-CoV assembling, virion release, and pathogenesis. Thus, the small molecules targeting SARS-CoV2 envelope protein could also be potential broad-spectrum anticoronavirus drugs, such as an inhibitor of E protein (Tomar et al, 2021;Wang et al, 2021). In summary, licorice may directly or indirectly protect target organs by inhibiting the binding of the virus to ACE2, antioxidant, and anti-fibrosis effects (Ming et al, 2020).…”

Section: Ace2 Inhibitionmentioning

confidence: 99%

Traditional Uses, Pharmacological Effects, and Molecular Mechanisms of Licorice in Potential Therapy of COVID-19

et al. 2021

View full text Add to dashboard Cite

The current Coronavirus disease 2019 (COVID-19) pandemic has become a global challenge, and although vaccines have been developed, it is expected that mild to moderate patients will control their symptoms, especially in developing countries. Licorice, not only a food additive, but also a common traditional Chinese herbal medicine, which has several pharmacological effects, such as anti-inflammation, detoxification, antibacterial, antitussive, and immunomodulatory effects, especially in respiratory diseases. Since the outbreak of COVID-19, glycyrrhizin, glycyrrhizin diamine and glycyrrhizin extract have been widely studied and used in COVID-19 clinical trials. Therefore, it is a very interesting topic to explore the material basis, pharmacological characteristics and molecular mechanism of licorice in adjuvant treatment of COVID-19. In this paper, the material basis of licorice for the prevention and treatment of COVID-19 is deeply analyzed, and there are significant differences among different components in different pharmacological mechanisms. Glycyrrhizin and glycyrrhetinic acid inhibit the synthesis of inflammatory factors and inflammatory mediators by blocking the binding of ACE 2 to virus spike protein, and exert antiviral and antibacterial effects. Immune cells are stimulated by multiple targets and pathways to interfere with the pathogenesis of COVID-19. Liquiritin can prevent and cure COVID-19 by simulating type I interferon. It is suggested that licorice can exert its therapeutic advantage through multi-components and multi-targets. To sum up, licorice has the potential to adjuvant prevent and treat COVID-19. It not only plays a significant role in anti-inflammation and anti-ACE-2, but also significantly improves the clinical symptoms of fever, dry cough and shortness of breath, suggesting that licorice is expected to be a candidate drug for adjuvant treatment of patients with early / mild COVID-19.

show abstract

“…Preliminary studies demonstrated the in-vivo and in-vitro anti-inflammatory activity of aqueous extracts of Ju. However, Ju alone caused obvious weight loss of the mice and it could be recovered by additional Gan extract ( Wang et al, 2021 ). Previously, we established an inflammatory endothelial cell model to screen and quantify a variety of anti-inflammatory Chinese herbal medicines ( Zhang et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

“…Previously, we established an inflammatory endothelial cell model to screen and quantify a variety of anti-inflammatory Chinese herbal medicines ( Zhang et al, 2018 ). Using this novel cell model, we found that Ju and Jin in association with Gan provided better anti-inflammatory effects along with increased immunity of the body ( Wang et al, 2021 ). As inflammation and tumorigenesis are closely related ( Weiss, 2008 ; Singh et al, 2019 ), we therefore examined the combined effects of anti-inflammatory and antitumor Chinese herbal formulations in both in vitro and in vivo conditions in the presence of tumor chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

An Optimized Two-Herb Chinese Food as Medicine Formula Reduces Cisplatin-Induced Nephrotoxicity in the Treatment of Lung Cancer in Mice

Shi

Shu

et al. 2022

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

Chemotherapy is considered a most effective way to treat cancer. However, it is very common that chemotherapy causes unbearable mental and physical side effects to cancer patients, which ultimately reduces the patients’ confidence of overcoming diseases and compromises the treatment of chemotherapy. Cisplatin (DDP), a widely used anticancer agent for various types of cancers, also damages nontumor cells and tissues, which are mostly related to the activation of the inflammation pathway. Previously, we have discovered a few rational formulas of food as medicine materials that reduced systemic inflammation in in vitro and in vivo models. Hence, this study reports the ability of an optimized traditional Chinese anti-inflammatory formulation capable of synergizing the antitumor effect of DDP in vitro and in vivo. More significantly, by formulation of two anti-inflammatory herbal medicine, the Chrysanthemum × morifolium (Ramat.) Hemsl [Asteraceae] and Lonicera japonica Thunb [Caprifoliaceae] with a mediator Glycyrrhiza uralensis Fisch. ex DC [Fabaceae], a best formula relieved the kidney damage imposed by DDP. Treatments of various combinations of major chemical components of the three herbs also exhibited a similar trend for lowering the DDP-induced nephrotoxicity; however, contrary to that of the formula of herbal extracts, all chemical formulas could not recover the body weight and food intake of the tumor-bearing mice treated by DDP. Our findings suggested that the therapeutic index of DDP-based chemotherapy was able to be improved by minimizing toxicities from the two-herb formula to inhibit the inflammation in mouse tumor models and DDP-induced acute kidney injury mouse models.

show abstract

Deciphering the Formulation Secret Underlying Chinese Huo-Clearing Herbal Drink

Cited by 6 publications

References 27 publications

Medical Species Used in Russia for the Management of Diabetes and Related Disorders

Medical Species Used in Russia for the Management of Diabetes and Related Disorders

Traditional Uses, Pharmacological Effects, and Molecular Mechanisms of Licorice in Potential Therapy of COVID-19

An Optimized Two-Herb Chinese Food as Medicine Formula Reduces Cisplatin-Induced Nephrotoxicity in the Treatment of Lung Cancer in Mice

Contact Info

Product

Resources

About