2005
DOI: 10.1002/mas.20067
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Deciphering the human nucleolar proteome

Abstract: Nucleoli are plurifunctional nuclear domains involved in the regulation of several major cellular processes such as ribosome biogenesis, the biogenesis of non-ribosomal ribonucleoprotein complexes, cell cycle, and cellular aging. Until recently, the protein content of nucleoli was poorly described. Several proteomic analyses have been undertaken to discover the molecular bases of the biological roles fulfilled by nucleoli. These studies have led to the identification of more than 700 proteins. Extensive biblio… Show more

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Cited by 87 publications
(87 citation statements)
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References 171 publications
(217 reference statements)
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“…This process requires more than 200 factors (Coute et al 2006) for a coordinated synthesis, maturation, assembly, and export into the cytoplasm of functional ribonucleic particles containing some 80 proteins and four ribosomal RNA (rRNA) (Lafontaine and Tollervey 2001). Recent studies tend to demonstrate that eukaryotic rRNA, like their prokaryotic counterparts, are ribozymes, allowing peptide bond formation as well as proofreading activities of the ribosomes (Cech 2000).…”
Section: Introductionmentioning
confidence: 99%
“…This process requires more than 200 factors (Coute et al 2006) for a coordinated synthesis, maturation, assembly, and export into the cytoplasm of functional ribonucleic particles containing some 80 proteins and four ribosomal RNA (rRNA) (Lafontaine and Tollervey 2001). Recent studies tend to demonstrate that eukaryotic rRNA, like their prokaryotic counterparts, are ribozymes, allowing peptide bond formation as well as proofreading activities of the ribosomes (Cech 2000).…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, the most recent data from nucleolar mass spectrometry analyses identified ~700 nucleolar proteins, among them many with no obvious relation to ribosome biogenesis (Andersen et al, 2005;Coute et al, 2006;Hinsby et al, 2006). Somewhat surprisingly, mapping the molecular components of nucleoli has not yet revealed insight into molecules that might be involved in the formation or maintenance of the nucleolar structure.…”
Section: Introductionmentioning
confidence: 99%
“…This process involves many different events taking place in the nucleolus: the transcription of rRNA genes by RNA polymerases I and III, the cleavage of primary rRNA transcripts into mature rRNA, their modification by methylation or pseudouridylation at more than 150 specific positions, and their assembly with ribosomal proteins (26). All of these events require the coordinated action of more than 170 nucleolar proteins mainly involved in ribosomal rRNA synthesis, cleavage, and posttranscriptional modifications (15) with the help of many snoRNAs. According to our present knowledge, the rate of ribosome biogenesis is determined mainly by the rate of rRNA synthesis and maturation, whereas ribosomal proteins that are produced in excess are rapidly degraded by the proteasome (15).…”
mentioning
confidence: 99%
“…All of these events require the coordinated action of more than 170 nucleolar proteins mainly involved in ribosomal rRNA synthesis, cleavage, and posttranscriptional modifications (15) with the help of many snoRNAs. According to our present knowledge, the rate of ribosome biogenesis is determined mainly by the rate of rRNA synthesis and maturation, whereas ribosomal proteins that are produced in excess are rapidly degraded by the proteasome (15). Most cancer cells are characterized by increased ribosome biogenesis, as evidenced by the frequent observation of hypertrophied nucleoli.…”
mentioning
confidence: 99%