2016
DOI: 10.3389/fnmol.2016.00098
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Deciphering the Role of Emx1 in Neurogenesis: A Neuroproteomics Approach

Abstract: Emx1 has long been implicated in embryonic brain development. Previously we found that mice null of Emx1 gene had smaller dentate gyri and reduced neurogenesis, although the molecular mechanisms underlying this defect was not well understood. To decipher the role of Emx1 gene in neural regeneration and the timing of its involvement, we determine the frequency of neural stem cells (NSCs) in embryonic and adult forebrains of Emx1 wild type (WT) and knock out (KO) mice in the neurosphere assay. Emx1 gene deletion… Show more

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Cited by 19 publications
(12 citation statements)
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“…Its methylation level was also differently expressed in hepatocellular carcinoma (HCC), which showed a potential role in the development of HCC (Sun et al, 2018). However, most of the research on EMX1 was focused on brain development (Lim et al, 2015; Kobeissy et al, 2016). The relationship between miR-497/EMX1 and cancer needs further study.…”
Section: Discussionmentioning
confidence: 99%
“…Its methylation level was also differently expressed in hepatocellular carcinoma (HCC), which showed a potential role in the development of HCC (Sun et al, 2018). However, most of the research on EMX1 was focused on brain development (Lim et al, 2015; Kobeissy et al, 2016). The relationship between miR-497/EMX1 and cancer needs further study.…”
Section: Discussionmentioning
confidence: 99%
“…Genes encoding transcription factors were among the neurodevelopment-related genes with reduced expression in both affected individuals. For example, ARX is required for normal telencephalic development and is associated with syndromic autism and other neurodevelopmental disorders [59], while EMX1 and FOXB1 also play important roles in neural development [6062]. Behavioral misregulation is a key trait of ASD, and gene networks related to the GO term ‘behavior’ exhibited dysregulated expression in both affected individuals.…”
Section: Discussionmentioning
confidence: 99%
“…ems/Emx1 control specification of the neuroectoderm early in embryogenesis, and they play subsequent roles during assembly of the olfactory sensory system and visual system where they control neuron development 30,56 . Exciting recent proteomics approaches have begun to elucidate the molecular features associated with Emx1 loss of functionin neurogenesis 57 , which may provide insights into EMX1 activities that will be relevant in the context of other tissues as well. Among EMX1 interacting partners is WDR11 , a WD domain-containing gene, mutations of which have been linked to Idopathic Hypogonadotropic Hypogonadism and Kallmann Syndrome (IHH/KS) in humans 58 .…”
Section: Discussionmentioning
confidence: 99%