Numerical simulations are a powerful tool to investigate turbulent flows, both for theoretical studies and practical applications. The reliability of a simulation is mainly dependent on the turbulence model adopted, and improving its accuracy is a crucial issue. In this study, we investigated the potential for an alternative formulation of the Navier–Stokes equations, based on the stochastic representation of the velocity field. The new approach, named pseudo-stochastic simulation (PSS), is a generalisation of the widespread classical eddy–viscosity model, where the contribution of the unresolved scales of motion is expressed by a variance tensor, modelled following different paradigms. The PSS models were compared with the classical ones mathematically and numerically in the turbulent channel flow at R e τ = 590 . The PSS and the classical models are equivalent when the variance tensor is shaped through a molecular dissipation analogy, while it is more accurate when the tensor is defined by the way of a local variance model. A near-wall damping function derived from recent advancement in the field is also proposed and was successfully validated. The analyses demonstrate the relevance of the approach proposed and provide a basis for the development of an alternative turbulence model.