The rapid technological development has influenced Indonesia's payment system. Due to the pandemic, people tend to seek cashless payment methods to limit physical contact. By using monthly time-series data from Bank Indonesia and Yahoo finance website during 2015-2020, to investigate the influence of the Covid-19 epidemic on E-Money transactions in Indonesia, this study uses the Mann-Whitney U test and Ordinary Least Square (OLS) regression methods. The findings reveal that before and after the application of PSBB in Indonesia, the volume and nominal value of E-Money transactions were significantly different. Moreover, Covid-19 correlates positively with the nominal value of E-Money. Inflation negatively correlates with E-Money, whereas the stock market has no impact on E-Money.