Declined Serum Resolvin D1 Levels to Predict Severity and Prognosis of Human Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study

Deng, Yu; Jiang, Fugui; Wang, Xu; He, Peng; Chen, Feng; Liu, Xiaobo; Bao, Xiang

doi:10.2147/ndt.s417630

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Several limitations are present in published studies on Rvs. Most studies on inflammationrelated diseases have primarily focused on RvD1 [50,[63][64][65][66]68,69]. Additionally, studies on the regulation of inflammatory substances and the phagocytosis and efferocytosis of macrophages predominantly employ the RvD series, whereas it is scarcely carried out within the RvE series.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have demonstrated the role of Rvs in inflammation. For instance, circulating levels of Rvs are significantly reduced in some inflammation-related diseases, such as aneurysmal subarachnoid hemorrhage, acute myocardial infarction, bipolar disorder, irritable bowel syndrome, acromegaly, and Hashimoto's thyroiditis [50,[63][64][65][66][67].…”

Section: Resolvins As Potential Therapeutic Targets In Inflammationmentioning

confidence: 99%

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Role of Resolvins in Inflammatory and Neuropathic Pain

Park,

Roh,

Pan

et al. 2023

Pharmaceuticals

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Chronic pain is an unpleasant experience associated with actual or potential tissue damage. Inflammatory pain alerts the body to inflammation and promotes healing; however, unresolved inflammation can lead to chronic pain. Conversely, neuropathic pain, due to somatosensory damage, can be a disease in itself. However, inflammation plays a considerable role in the progression of both types of pain. Resolvins, derived from omega-3 fatty acids, actively suppress pro-inflammatory mediators and aid in the resolution of inflammation. Resolvins alleviate various inflammatory and neuropathic pain models by reducing hypersensitivity and regulating inflammatory cytokines and glial activation in the spinal cord and dorsal root ganglia. Thus, resolvins are a promising alternative for pain management with the potential to reduce the side effects associated with conventional medications. Continued research is crucial to unlock the therapeutic potential of resolvins and integrate them into effective clinical pain management strategies. This review aimed to evaluate the literature surrounding the resolvins in inflammatory and neuropathic pain.

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Section: Discussionmentioning

confidence: 99%

Section: Resolvins As Potential Therapeutic Targets In Inflammationmentioning

confidence: 99%

Role of Resolvins in Inflammatory and Neuropathic Pain

Park,

Roh,

Pan

et al. 2023

Pharmaceuticals

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Biosynthesis of resolvin D1, resolvin D2, and RCTR1 from 7,8(S,S)-epoxytetraene in human neutrophils and macrophages

Nshimiyimana,

Simard,

Teder

et al. 2024

Proc. Natl. Acad. Sci. U.S.A.

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While the acute inflammatory response to harmful stimuli is protective, unrestrained neutrophil swarming drives collateral tissue damage and inflammation. Biosynthesized from omega-3 essential polyunsaturated fatty acids, resolvins are a family of signaling molecules produced by immune cells within the resolution phase to orchestrate return to homeostasis. Understanding the mechanisms that govern biosynthesis of these potent molecules gives insight into stimulating endogenous resolution and offers fresh opportunities for preventing and treating excessive inflammation. In this report, using materials prepared by total synthesis and liquid chromatography and tandem mass spectrometry-based matching studies, we established the role of 7,8(S,S)-epoxytetraene intermediate in the biosynthesis of resolvin D1, resolvin D2, and the resolvin conjugate in tissue regeneration (RCTR1) by human phagocytes. We demonstrated that this 7,8(S,S)-epoxy-containing intermediate is directly converted to resolvin D2 by human M2-like macrophages and to resolvin D1 and RCTR1 by human macrophages, neutrophils, and peripheral blood mononuclear cells. In addition, both human recombinant soluble epoxide hydrolase (sEH) and the glutathione S-transferase leukotriene C4synthase (LTC4S) each catalyze conversion of this epoxide to resolvin D1 and RCTR1, respectively. MS3ion-trap scans and isotope incorporation of18O from H218O with sEH indicated that the oxygen atom at C-8 in resolvin D1 is derived from water. Results from molecular docking simulations with biosynthetic precursor 17S-hydroperoxy-4,7,10,13,19-cis-15-trans-docosahexaenoic acid and the epoxy intermediate were consistent with 5-lipoxygenase production of resolvin D1. Together, these results give direct evidence for the role of resolvin 7,8(S,S)-epoxytetraene intermediate in the endogenous formation of resolution-phase mediators resolvin D1, resolvin D2, and RCTR1 by human phagocytes.

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Declined Serum Resolvin D1 Levels to Predict Severity and Prognosis of Human Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study

Cited by 2 publications

References 25 publications

Role of Resolvins in Inflammatory and Neuropathic Pain

Role of Resolvins in Inflammatory and Neuropathic Pain

Biosynthesis of resolvin D1, resolvin D2, and RCTR1 from 7,8(S,S)-epoxytetraene in human neutrophils and macrophages

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