Decoding of Non-Coding DNA and Non-Coding RNA: Pri-Micro RNA-Encoded Novel Peptides Regulate Migration of Cancer Cells

Fang, Jinbo; Morsalin, Sharif; Rao, VeenaN.; Reddy, E. ShyamP.

doi:10.1166/jpsp.2017.1070

Cited by 40 publications

(36 citation statements)

References 20 publications

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“…This peptide regulated myoblast proliferation [78]. MiPEP-200a and miPEP-200b, encoded by primary miRNAs (miR-200a and miR-200b), can inhibit the migration of prostate cancer cells by regulating the epithelial to mesenchymal transition of tumor cells [191]. CircRNAs, lncRNAs, and the small peptides they encode may regulate tumorigenesis.…”

Section: Other Functional Peptidesmentioning

confidence: 99%

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

et al. 2020

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Non-coding RNAs do not encode proteins and regulate various oncological processes. They are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics and translation omics have begun to elucidate the roles and modes of action of the functional peptides encoded by ncRNA. Here, recent advances in long non-coding RNA (lncRNA) and circular RNA (circRNA)-encoded small peptides are compiled and synthesized. We introduce both the computational and analytical methods used to forecast prospective ncRNAs encoding oncologically functional oligopeptides. We also present numerous specific lncRNA and circRNA-encoded proteins and their cancer-promoting or cancer-inhibiting molecular mechanisms. This information may expedite the discovery, development, and optimization of novel and efficacious cancer diagnostic, therapeutic, and prognostic protein-based tools derived from non-coding RNAs. The role of ncRNA-encoding functional peptides has promising application perspectives and potential challenges in cancer research. The aim of this review is to provide a theoretical basis and relevant references, which may promote the discovery of more functional peptides encoded by ncRNAs, and further develop novel anticancer therapeutic targets, as well as diagnostic and prognostic cancer markers.

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Section: Other Functional Peptidesmentioning

confidence: 99%

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

et al. 2020

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“…The primary microRNA, miR-200a and miR-200b, that encode proteins (miPEP-200a and miPEP-200b) can inhibit the migration of prostate cancer cells, and it was observed that low-level expression of miPEP-200a and miPEP-200b were associated with poor survival outcome in cancer patients. This evidence indicated that miPEP-200a and miPEP-200b have the potential to be used as diagnostic and prognostic markers ( Fang et al, 2017 ).…”

Section: Peptides/proteins Encoded By Ncrna As Promising Cancer Biomamentioning

confidence: 97%

“…Only 2% of the human genome is able to code for proteins or peptides, and the rest is actively transcribed into ncRNAs ( Fang et al, 2017 ). Surprisingly, a limited number of “ncRNAs” have recently shown the ability to encode proteins or peptides.…”

Section: Peptides/small Proteins Encoded By Ncrna As Promising Candidmentioning

confidence: 99%

“…Impressively, Fang et al (2017) found that two proteins (miPEP-200a and miPEP-200b) were encoded by miR-200a and miR-200b, respectively. The experiment results indicated that miPEP-200a and miPEP-200b suppressed the migration of prostate cancer cells through regulating the epithelial to mesenchymal transition of tumor cells.…”

Section: Peptides/small Proteins Encoded By Ncrna As Promising Candidmentioning

confidence: 99%

“…For a long time, there has been widespread recognition that ncRNA are unable to encode proteins ( Guttman et al, 2013 ). However, with the development of deep ribosome profiling sequencing (Ribo-Seq) technology, mass spectrometry and algorithms including fragment length organization similarity score (FLOSS; Ingolia et al, 2014 ), ORF-RATER ( Fields et al, 2015 ), and Ribo taper ( Calviello et al, 2016 ), a subset of ncRNA have been identified to be able to encode peptides (<100 amino acids) or proteins, such as HOXB-AS3 ( Huang et al, 2017 ), SPAR ( Matsumoto et al, 2017 ), FBXW7-185aa ( Yang et al, 2018 ), SHPRH-146aa ( Zhang et al, 2018 ), miPEP-200a, and miPEP-200b ( Fang et al, 2017 ; Figure 1 ). HOXB-AS3 and SPAR are encoded by long non-coding RNA (lncRNA).…”

Section: Introductionmentioning

confidence: 99%

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Peptides/Proteins Encoded by Non-coding RNA: A Novel Resource Bank for Drug Targets and Biomarkers

Zhu

Wang

et al. 2018

Front. Pharmacol.

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Non-coding RNAs (ncRNAs) are defined as RNA molecules that do not encode proteins, but recent evidence has proven that peptides/proteins encoded by ncRNAs do indeed exist and usually contain less than 100 amino acids. These peptides/proteins play an important role in regulating tumor energy metabolism, epithelial to mesenchymal transition of cancer cells, the stability of the c-Myc oncoprotein, and the ubiquitination and degradation of proliferating cell nuclear antigen (PCNA). These peptides/proteins represent promising drug targets for fighting against tumor growth or biomarkers for predicting the prognosis of cancer patients. In this review, we summarize the characteristics of peptides/proteins that have recently been identified as putative ncRNA translation products and their outlook for small molecule peptide drugs, drug targets, and biomarkers.

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The Small Open Reading Frame‐Encoded Peptides: Advances in Methodologies and Functional Studies

et al. 2021

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Small open reading frames (sORFs) are an important class of genes with less than 100 codons. They were historically annotated as noncoding or even junk sequences. In recent years, accumulating evidence suggests that sORFs could encode a considerable number of polypeptides, many of which play important roles in both physiology and disease pathology. However, it has been technically challenging to directly detect sORF‐encoded peptides (SEPs). Here, we discuss the latest advances in methodologies for identifying SEPs with mass spectrometry, as well as the progress on functional studies of SEPs.

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Decoding of Non-Coding DNA and Non-Coding RNA: Pri-Micro RNA-Encoded Novel Peptides Regulate Migration of Cancer Cells

Cited by 40 publications

References 20 publications

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

Peptides/Proteins Encoded by Non-coding RNA: A Novel Resource Bank for Drug Targets and Biomarkers

The Small Open Reading Frame‐Encoded Peptides: Advances in Methodologies and Functional Studies

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