Decorated silica particles with terbium complexes as luminescent biomarker for cell imaging

Mutti, A.M.G.; Santos, J.A.O.; Cavalcante, Dalita Gomes Silva Morais; Gomes, Andressa Silva; Job, Aldo Eloízo; Pires, Ana Maria; Lima, Sergio A. M.

doi:10.1016/j.optmat.2019.02.019

Cited by 11 publications

(6 citation statements)

References 30 publications

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“…Figure S5 shows the fluorescence microscopy images of CHO-k1 marked with DAPI blue-emitting nuclear stain and the red-emitting S 1 -[Eu(dbm)] hybrid. The tests were performed by exposing the cells to the hybrid for 2 h at concentrations of 62.5 and 125 µg/mL (for further details, see Note S1) [12,33]. The images in Figure S5 suggest that the hybrid was internalized by cells, crossing the cellular membrane and localized in intracellular regions at both concentrations tested.…”

Section: By Using φ Lnmentioning

confidence: 99%

“…Among several support materials for the luminescent complex immobilization, SiO 2 stands out as a biocompatible and non-toxic material for most cell lines due to the ease surface modification, entailing versatility for biofunctionalization by a substantial number of molecules [23][24][25]. Several methodologies can be employed to modify dense or mesoporous SiO 2 surface to fabricate biomarkers, such as, complexes impregnation into the pores [26,27], encapsulation within the nanoparticle [28][29][30], immobilization by electrostatic interaction (cationic and anionic complexes) [31] or covalently-anchor onto the nanoparticle surface [12,[32][33][34]. In this last case, the covalent bond avoids the complexes release in the cell environment and luminescence quenching compared to encapsulated architectures.…”

Section: Introductionmentioning

confidence: 99%

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Red-Emitting Hybrid Based on Eu3+-dbm Complex Anchored on Silica Nanoparticles Surface by Carboxylic Acid for Biomarker Application

et al. 2020

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Luminescent organic-inorganic hybrids containing lanthanides (Ln3+) have been prominent for applications such as luminescent bio-probes in biological assays. In this sense, a luminescent hybrid based on dense silica (SiO2) nanospheres decorated with Eu3+ β–diketonate complexes using dibenzoylmethane (Hdbm) as a luminescent antenna was developed by using a hierarchical organization in four steps: (i) anchoring of 3-aminopropyltriethoxysilane (APTES) organosilane on the SiO2 surface, (ii) formation of a carboxylic acid ligand, (iii) coordination of Eu3+ to the carboxylate groups and (iv) coordination of dbm− to Eu3+. The hybrid structure was elucidated through the correlation of thermogravimetry, silicon nuclear magnetic resonance and photoluminescence. Results indicate that the carboxylic acid-Eu3+-dbm hybrid was formed on the surface of the particles with no detectable changes on their size or shape after all the four steps (average size of 32 ± 7 nm). A surface charge of −27.8 mV was achieved for the hybrid, assuring a stable suspension in aqueous media. The Eu3+ complex provides intense red luminescence, characteristic of Eu3+5D0→7FJ electronic transitions, with an intrinsic emission quantum yield of 38%, even in an aqueous suspension. Therefore, the correlation of luminescence, structure, particle morphology and fluorescence microscopy images make the hybrid promising for application in bioimaging.

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Section: By Using φ Lnmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Red-Emitting Hybrid Based on Eu3+-dbm Complex Anchored on Silica Nanoparticles Surface by Carboxylic Acid for Biomarker Application

et al. 2020

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“…McCusker's research group reported that the Cr(acac) 3 complex upon excitation in the 4 T 2 LF excited state undergoes ultrafast ISC (τ ISC < 100 fs) in the vibrationally hot 2 E LF state followed by vibrational relaxation (1−2 ps time constant). 15 However, the excited-state dynamics of Cr(t-Bu-acac) 3 differs from the dynamics of the similar Cr(acac) 3 . The small change in ligand nature led to prolongation of the ISC process by an order of magnitude (τ ISC ∼ 1.8 ± 0.4 ps).…”

Section: ■ Introductionmentioning

confidence: 97%

Ultrafast Photochemistry of the [Cr(NCS)₆]^3– Complex in Dimethyl Sulfoxide and Dimethylformamide upon Excitation into Ligand-Field Electronic State

et al. 2020

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The ultrafast photochemistry of the [Cr(NCS)6]3– complex upon excitation to the 4T2 ligand-field (LF) state was studied in dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF) in a wide temporal range (100 fs to 9 ms) by a combination of femtosecond and nanosecond transient absorption spectroscopy techniques and supported by quantum-chemical DFT/TD-DFT calculations. The initially excited 4T2 state undergoes intersystem crossing to the vibrationally hot 2E state with time constants of 1.1 ± 0.2 and 1.8 ± 0.1 ps in DMSO and DMF, respectively. Vibrational relaxation occurs in the same time scale and takes 1–5 ps. A major part of the [Cr(NCS)6]3– complex in the 2E state undergoes intersystem crossing to the ground state with time constants of 65 ± 5 and 85 ± 5 ns in DMSO and DMF, respectively. A minor part of electronically excited [Cr(NCS)6]3– undergoes irreversible photochemical decomposition. In DMSO, the photolysis of the [Cr(NCS)6]3– complex results in single or double isothiocyanate ion release followed by the coordination of the solvent molecules with a time constant of 1 ± 0.2 ms.

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“…Luminescent or phosphor materials have proven their worth because of their different applications, they are used as sensors, cell markers, light-emitting diodes, and solar cells, among other applications [1][2][3][4]. Phosphors can be synthesized as thin films on different substrates, depending on the application, but some of them are synthesized as powders that can be pressed in pellet shape or glued on a surface.…”

Section: Introductionmentioning

confidence: 99%

Effect of low-density polyethylene on the luminescent properties of thulium-doped yttrium oxide obtained by the polyol technique

Alarcón-Flores¹,

Garduño-Wilches²,

Alarcón

et al. 2020

Mater. Res. Express

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In the present work polyethylene is used as a support of yttrium oxide particles doped with thulium atoms and its effect on the luminescent properties is studied. Thulium-doped yttrium oxide was prepared through the polyol method, different values of thulium are explored: 0, 0.5, 1, 1.5, 2.5 and 3.5 at%, as well as different calcinating temperatures: 400, 600, 800 and 1000°C, are explored in order to determine the synthesis conditions needed for the maximum emission intensity, whose values were 1.5 at% of thulium and 1000°C. The synthesized powder is dispersed in low-density polyethylene and dispersed as a thin film on glass substrates. The luminescent excitation and emission spectra showed important changes attributed to the influence of the -CH 2chain vibration; in addition, the presence of the polymer had an important influence on the emission decay time: while the powder showed a single emission process with a time of 9.293 μs, the film showed a two decay process with 1.156 μs and 4.086 μs, each.

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Decorated silica particles with terbium complexes as luminescent biomarker for cell imaging

Cited by 11 publications

References 30 publications

Red-Emitting Hybrid Based on Eu3+-dbm Complex Anchored on Silica Nanoparticles Surface by Carboxylic Acid for Biomarker Application

Red-Emitting Hybrid Based on Eu3+-dbm Complex Anchored on Silica Nanoparticles Surface by Carboxylic Acid for Biomarker Application

Ultrafast Photochemistry of the [Cr(NCS)₆]^3– Complex in Dimethyl Sulfoxide and Dimethylformamide upon Excitation into Ligand-Field Electronic State

Effect of low-density polyethylene on the luminescent properties of thulium-doped yttrium oxide obtained by the polyol technique

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Decorated silica particles with terbium complexes as luminescent biomarker for cell imaging

Cited by 11 publications

References 30 publications

Red-Emitting Hybrid Based on Eu3+-dbm Complex Anchored on Silica Nanoparticles Surface by Carboxylic Acid for Biomarker Application

Red-Emitting Hybrid Based on Eu3+-dbm Complex Anchored on Silica Nanoparticles Surface by Carboxylic Acid for Biomarker Application

Ultrafast Photochemistry of the [Cr(NCS)6]3– Complex in Dimethyl Sulfoxide and Dimethylformamide upon Excitation into Ligand-Field Electronic State

Effect of low-density polyethylene on the luminescent properties of thulium-doped yttrium oxide obtained by the polyol technique

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Ultrafast Photochemistry of the [Cr(NCS)₆]^3– Complex in Dimethyl Sulfoxide and Dimethylformamide upon Excitation into Ligand-Field Electronic State