Decoration of gold and silver nanoparticles by neuroprotective gabapentin drug and studying the release behavior by surface plasmon resonance

Liu, Bo; Liu, Guiyang; Zhang, Bo

doi:10.1007/s11696-021-01661-4

Cited by 5 publications

(2 citation statements)

References 44 publications

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“…Various decomposition techniques have been reported for Gabapentin drugs in clinical samples, including high-performance liquid chromatography (HPLC), Mass spectrometry, and Gas chromatography (GC). 26 HPLC and GC methods require Gabapentin derivatives to produce chromophores detectable by UV/F. Moreover, GC requires Gabapentin derivatives to improve oscillation and prevent column interactions.…”

Section: Discussionmentioning

confidence: 99%

Design and Production of DNA-Based Electrochemical and Biological Biosensors for the Detection and Measurement of Gabapentin Medication in Clinical Specimens

Aghazadeh¹,

Ebnetorab²,

shahriari³

et al. 2022

J. Electrochem. Soc.

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Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drugs at designated intervals to maintain a constant concentration in a patient’s bloodstream, thereby optimizing individual dosage regimens. Hence, the extant study was conducted to design and produce an electrochemical and biological biosensor to detect and measure Gabapentin medication. The present study was a laboratory-applied intervention, which used a pencil graphite electrode modified with α-Fe2O3 and MOS2 nanostructures in one step and DNA in the second address layer, by using Differential Pulse Voltammetry (DPV) electrochemical sensing techniques to detect Gabapentin medication in clinical specimens such as serum, plasma, and urine. The functional mechanism of the biosensor is designed in such a way that the effect of interaction between drug and DNA leads to drug detection, and with increasing concentration of Gabapentin analyte, the amount of visible current by DNA is reduced. Significantly, this reduction in current after reaction with Gabapentin can be demonstrated using the Differential Pulse Voltammogram (DPV) curve. The designed biosensor provided some features, including inexpensiveness, simple and fast sensor biodegradation process, appropriate stability of sensor, low Limit of Detection (LOD), extensive linearity range, ease of application without requiring laboratory technician, and selectivity of biosensor materials. Electrochemical and biological biosensors have some advantages rather than the common analytical methods; hence, these biosensors can be used widely in the future. High selectivity, low cost of production and low energy consumption, accuracy and precision, short response time, adaptability, simple preparedness, minimization capability, high-speed data collecting, low LOD, minor operational volume, and robust measurement. On the other hand, biosensors have received great attention over recent years due to their continuous application, the high selectivity of biological compounds, such as enzymes and antibodies, and the ability to measure nonpolar compounds.

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Section: Discussionmentioning

confidence: 99%

Design and Production of DNA-Based Electrochemical and Biological Biosensors for the Detection and Measurement of Gabapentin Medication in Clinical Specimens

Aghazadeh¹,

Ebnetorab²,

shahriari³

et al. 2022

J. Electrochem. Soc.

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“…They also exist in different shapes and sizes and can be free and composed of inorganic or organic moieties. − Due to their extremely small size and large surface-area-to-volume ratio, their physical and chemical properties vary in the surface and bulk with the same composition. They show a huge variation in their shape and size, due to which they exhibit a broad range of applications in different areas such as catalysis; biosensing; biological activity; drug delivery; electronics; and also in the field of medicine, pharmacy, and so on.…”

Section: Introductionmentioning

confidence: 99%

Detailed Kinetic and Mechanistic Study for the Preparation of Silver Nanoparticles by a Chemical Reduction Method in the Presence of a Neuroleptic Agent (Gabapentin) at an Alkaline pH and its Characterization

et al. 2022

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For the very first time, a detailed kinetic study for the preparation of silver nanoparticles (silver NPs) by neuroleptic agent gabapentin (GBP) in the absence of a stabilizer has been reported in this investigation. This paper is devoted to the preparation of silver nanoparticles by a chemical reduction method in which gabapentin acts as both a reductant and a stabilizer, and AgNO3 is used as a source of Ag+ ions and NaOH for maintaining the alkaline medium. A UV–visible spectrophotometer is used to monitor the progress of the reaction kinetics in an aqueous medium by changing the concentration of different variables such as AgNO3, NaOH, and gabapentin at 40 °C. It is found that the reaction rate follows a pseudo-first-order reaction. The thermodynamic activation parameters were also studied at five different temperatures (303, 308, 313, 318, and 323 K) and used in the support of the proposed mechanistic scheme for the formation of silver nanoparticles. The prepared silver nanoparticles were characterized using different techniques: UV–visible spectrophotometry, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, transmission electron microscopy, and powder X-ray diffraction. The average particle size was observed in the range of 5–45 nm.

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Biosensors technology for anti-epileptic drugs

Mobed

Shirafkan²,

Charsouei³

et al. 2022

Clinica Chimica Acta

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Decoration of gold and silver nanoparticles by neuroprotective gabapentin drug and studying the release behavior by surface plasmon resonance

Cited by 5 publications

References 44 publications

Design and Production of DNA-Based Electrochemical and Biological Biosensors for the Detection and Measurement of Gabapentin Medication in Clinical Specimens

Design and Production of DNA-Based Electrochemical and Biological Biosensors for the Detection and Measurement of Gabapentin Medication in Clinical Specimens

Detailed Kinetic and Mechanistic Study for the Preparation of Silver Nanoparticles by a Chemical Reduction Method in the Presence of a Neuroleptic Agent (Gabapentin) at an Alkaline pH and its Characterization

Biosensors technology for anti-epileptic drugs

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