Biosensors technology for anti-epileptic drugs

Mobed, Ahmad; Shirafkan, Mahdiye; Charsouei, Saeid; Ahmadalipour, Ali

doi:10.1016/j.cca.2022.06.027

Cited by 14 publications

(8 citation statements)

References 60 publications

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“…Nanomaterials or nanomedicine, especially biosensor-based methods, can facilitate the analysis of these agents with unique advantages such as rapid analysis, sensitivity, selectivity, and low cost. Additionally, various chemical and biological modifiers to improve the sensitivity and selectivity of the sensor have been also been categorized [ 28 ]. These new molecules have been developed in order to provide a pharmaceutical profile and tolerance superior to the previously available drugs, and it is forecast that as their use increases, their true potential and profile will be widen.…”

Section: Study Resultsmentioning

confidence: 99%

The Metabolic Role of Ketogenic Diets in Treating Epilepsy

et al. 2022

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Epilepsy is a long-term neurological condition that results in recurrent seizures. Approximately 30% of patients with epilepsy have drug-resistant epilepsy (DRE). The ketogenic diet (KD) is considered an effective alternative treatment for epileptic patients. The aim of this study was to identify the metabolic role of the KD in epilepsy. Ketone bodies induce chemical messengers and alterations in neuronal metabolic activities to regulate neuroprotective mechanisms towards oxidative damage to decrease seizure rate. Here, we discuss the role of KD on epilepsy and related metabolic disorders, focusing on its mechanism of action, favorable effects, and limitations. We describe the significant role of the KD in managing epilepsy disorders.

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Section: Study Resultsmentioning

confidence: 99%

The Metabolic Role of Ketogenic Diets in Treating Epilepsy

et al. 2022

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“…Utilizing nanoparticles can facilitate the examination of these compounds. 26 A nanocomposite sensor of reduced graphene oxide and Pt nanoparticles immobilized on a modified glassy carbon electrode (nPtGN/GCE) has been developed. The electrochemically catalyzed phenobarbital (PB) reactions with the modified electrode showed exceptional activity.…”

Section: Pencil Graphite Electrode Basedmentioning

confidence: 99%

“…This sensor was used to develop a mediator-free PB detection sensor, which has proper LOD and linearity, and can reliably detect PB in actual samples. 26 Biosensors are becoming increasingly crucial in anti-epileptic drug (AED) monitoring due to their ability to simultaneously measure multiple AEDs and their metabolites in biological samples. These new techniques are expected to simplify, quicken, and measure AED levels in the blood more cost-effective.…”

Section: Pencil Graphite Electrode Basedmentioning

confidence: 99%

Biosensors for therapeutic drug monitoring: a review

et al. 2023

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Therapeutic drug monitoring (TDM) is a crucial and essential step for patient care when an accurate medication dosage is necessary. High-performance liquid chromatography (HPLC) and immunoassays are commonly used methods for TDM, but they are expensive and incapable of real-time monitoring. Biosensor technology is believed to have the potential to perform TDM effectively. Biosensors are flexible and can be tailored to individual patient needs. This article reviews the development of biosensors for TDM, including the types of biosensors that have been fabricated and the drugs they have successfully monitored. Biosensor technology is expected to have a bright future, particularly for real-time monitoring and integration with internet of things (IoT) systems.

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“…EEG is counted as a top graded and most standard analytical system. [84] The theoretical interpretation from the obtained data aids to identify the types of seizures slight prior to their happening. In consideration of this approach, researchers strive to focus on warning singles.…”

Section: Epilepsy/seizurementioning

confidence: 99%

Recent Progress on Biosensors for the Early Detection of Neurological Disorders.

Chougale

Vedante

Kulkarni³

et al. 2022

ChemistrySelect

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Neurological disorders are a point of attraction these days due to their physical, mental, and genetic threat to human beings. The researchers are refining the therapeutics and striving to eradicate the life-threatening burden of chronic diseases by upsurging and proposing advanced instrumentation. There are a number of neurological diseases that cause alterations in the genetic sequences due to pathogenic or self-negligence. According to the WHO, stroke, septicemia, PD, epilepsy, and MS are found to be the deadliest and most invading among millions of people. Various diagnostic methods are employed for monitoring these disorders in the human body at an early stage, in process of cure. The current review highlights the strengths of several advanced detection devices, such as biosensors to identify and quantify biomarkers, some sensing gadgets, and other genetic tactics or innovations to ameliorate traditional protocols. Furthermore, the meticulous description of ongoing experiments with the help of relevant case studies of neurodegenerative disorders supports the impact and vitality of advanced equipment. Further, the necessity of biosensors in distinct disorders to aid in an early diagnosis, and the influence of nano-based materials in preparation is emphasized. Finally, several issues that should be addressed in upcoming decades with the steep rise in analytical technology have been discussed.

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Biosensors technology for anti-epileptic drugs

Cited by 14 publications

References 60 publications

The Metabolic Role of Ketogenic Diets in Treating Epilepsy

The Metabolic Role of Ketogenic Diets in Treating Epilepsy

Biosensors for therapeutic drug monitoring: a review

Recent Progress on Biosensors for the Early Detection of Neurological Disorders.

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