Decrease and Senescence of Endothelial Progenitor Cells in Patients With Preeclampsia

Sugawara, Junichi; Mitsui-Saito, Minori; Hayashi, Chika; Hoshiai, Tetsuro; Senoo, Masato; Chisaka, Hiroshi; Yaegashi, Nobuo; Okamura, Koji

doi:10.1097/01.ogx.0000224611.62375.f7

Cited by 34 publications

(46 citation statements)

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“…The possibility that it may reflect the alterations in cell composition and competence, both in general and progenitor/stem cell population, as well as alternations in cell functionality appear to deserve credence. The existence of dysfunctional EPCs originating from BM has been documented in atherosclerosis, 6,22 essential hypertension, 23,24 preeclampsia, 25 hyperglycemia, 26 smoking 24,27 and type I and type II diabetes patients. 28 -30 It has recently been shown that diabetic state promotes aging of cardiac stem cells, a tissue resident stem cell population, and contribute to the heart failure.…”

Section: Discussionmentioning

confidence: 99%

Adoptive Transfer of Syngeneic Bone Marrow-Derived Cells in Mice with Obesity-Induced Diabetes

Chen

Addabbo

et al. 2009

The American Journal of Pathology

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There are conflicting data regarding the effects of transplantation of bone marrow-derived cells (BMDCs) on the severity of diabetes. We therefore inquired whether the competence of BMDCs is preserved on adoptive transfer into diabetic (db/db) mice and how the adoptive transfer of BMDCs affects vascular and metabolic abnormalities in these mice. Recipient db/db mice received infusions of BMDCs prepared from either db/db or non-diabetic heterozygout mice (db/m) mice and effects on endothelium-dependent relaxation, insulin sensitivity, and renal function were evaluated. Recipients of BMDCs from db/m, but not db/db donors showed better glucose control, exhibited striking improvement in endothelium-dependent relaxation in response to acetylcholine, and had partially restored renal function. Improved glucose control was due to enhanced insulin sensitivity, most likely secondary to improved vascular function. Enhanced apoptosis of endothelial progenitor cells under oxidative stress, as well as decreased endothelial progenitor cell numbers were responsible for the apparent functional incompetence of BMDCs from db/db donors. Treatment of db/db mice with Ebselen restored the resistance of both BMDCs and endothelial progenitor cells to oxidative stress , improved acetylcholine-induced vasorelaxation , and reduced proteinuria in db/db recipients of BMDC transplantation. In conclusion, infusion of BMDCs obtained from db/m donors to db/db recipient mice benefited macrovascular function, insulin sensitivity, and nephropathy. BMDCs obtained from db/db mice were functionally incompetent secondary to the increased proportion of apoptotic cells on oxidative stress challenge; their competence was restored by

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Section: Discussionmentioning

confidence: 99%

Adoptive Transfer of Syngeneic Bone Marrow-Derived Cells in Mice with Obesity-Induced Diabetes

Chen

Addabbo

et al. 2009

The American Journal of Pathology

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“…Change in cell number/function References Pregnancy Increase of EPCFderived colonies 97,98 Chronic renal failure /dialysis/ Decreased EPC number, EPC-derived colonies, and reduced migration to VEGF 53 Therefore, the enumeration of circulating EPCs may be used in risk stratification, because it seems to reflect the global burden of CV risk factors. 54 …”

Section: Factormentioning

confidence: 99%

Mobilization of stem and progenitor cells in cardiovascular diseases

et al. 2011

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Circulating bone marrow (BM)-derived stem and progenitor cells (SPCs) participate in turnover of vascular endothelium and myocardial repair after acute coronary syndromes. Acute myocardial infarction (MI) produces a generalized inflammatory reaction, including mobilization of SPCs, increased local production of chemoattractants in the ischemic myocardium, as well as neural and humoral signals activating the SPC egress from the BM. Several types of circulating BM cells were identified in the peripheral blood, including hematopoietic stem cells, endothelial progenitor cells, mesenchymal stromal cells, circulating angiogenic cells and pluripotent very small embryonic-like cells; however, the contribution of circulating cells to the myocardial and endothelial repair is still unknown. The number and function of these cells is impaired in patients with diabetes and other cardiovascular risk factors, but can be improved by physical exercise and use of statins. The mobilization of SPCs in acute coronary syndromes and stable coronary artery disease seems to predict the clinical outcomes in selected groups of patients. Interpretation of the findings has to incorporate other factors that modulate the process of mobilization, such as coexisting diseases, age and medications. This review discusses the mobilization of SPCs in acute ischemia (MI, stroke), as well as in stable cardiovascular disease, and highlights the possibility of using the SPC as a marker of cardiovascular risk.

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“…Initial studies reported a reduction in circulating EPCs in individuals with coronary artery disease and in those adults with a high cardiovascular disease risk predicted by a Framingham risk factor score (19,20). Interestingly, this paradigm has held for multiple disease states in adults including diabetes, peripheral vascular disease, rheumatoid arthritis, and preeclampsia (21)(22)(23)(24). However, no studies have been reported in infants or children.…”

mentioning

confidence: 99%

In Vitro Hyperglycemia or a Diabetic Intrauterine Environment Reduces Neonatal Endothelial Colony-Forming Cell Numbers and Function

et al. 2008

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OBJECTIVE-Emerging data demonstrate that maternal diabetes has long-term health consequences for offspring, including the development of hypertension. In adults, circulating endothelial progenitor cells (EPCs) participate in vascular repair, and EPC numbers and function inversely correlate with the risk of developing vascular disease. Therefore, our objectives were to determine whether hyperglycemia or exposure to a diabetic intrauterine environment alters EPC function. RESEARCH DESIGN AND METHODS-We used well-established clonogenic endothelial colony-forming cell (ECFC) assays and murine transplantation experiments to examine human vasculogenesis.RESULTS-Both in vitro hyperglycemia and a diabetic intrauterine environment reduced ECFC colony formation, self-renewal capacity, and capillary-like tube formation in matrigel. This cellular phenotype was linked to premature senescence and reduced proliferation. Further, cord blood ECFCs from diabetic pregnancies formed fewer chimeric vessels de novo after transplantation into immunodeficient mice compared with neonatal ECFCs harvested from uncomplicated pregnancies. CONCLUSIONS-Collectively, these data demonstrate that hyperglycemia or exposure to a diabetic intrauterine environment diminishes neonatal ECFC function both in vitro and in vivo, providing potential mechanistic insights into the long-term cardiovascular complications observed in newborns of diabetic pregnancies. Diabetes 57:724-731, 2008

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Decrease and Senescence of Endothelial Progenitor Cells in Patients With Preeclampsia

Cited by 34 publications

References 0 publications

Adoptive Transfer of Syngeneic Bone Marrow-Derived Cells in Mice with Obesity-Induced Diabetes

Adoptive Transfer of Syngeneic Bone Marrow-Derived Cells in Mice with Obesity-Induced Diabetes

Mobilization of stem and progenitor cells in cardiovascular diseases

In Vitro Hyperglycemia or a Diabetic Intrauterine Environment Reduces Neonatal Endothelial Colony-Forming Cell Numbers and Function

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