Decrease in cerebellar blood flow in patients with Friedreich’s ataxia: A TC-HMPAO SPECT study of three cases

Giroud, Maude; Septien, L; Pelletier, J.L.; Dueret, N.; Dumas, R

doi:10.1080/01616412.1994.11740251

Cited by 13 publications

(1 citation statement)

References 7 publications

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“…A wide variety of patterns of cerebellar atrophy, which do not correlate with specific neurological disorders, are relatively common in spinocerebellar degeneration (SCD). A significant decrease in cerebellar blood flow was shown by 99m-Tc-HMPAO SPECT in patients with Friedreich's ataxia and slight atrophy of the vermis and cerebellar lobes on CT or MRI [15]. In patients with SCD patients an no apparent cerebellar atrophy on CT, positron emission tomography showed significantly low cerebellar blood flow and cerebral metabolic rates; with advancing of cerebellar atrophy, these tended to fall further [16].…”

Section: Discussionmentioning

confidence: 99%

Cerebellar blood flow in methylmercury poisoning (Minamata disease)

et al. 2001

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We looked at regional cerebellar blood flow in patients with Minamata disease (MD) using technetium-99m ethyl cysteinate dimer (99m-Tc-ECD). We carried out single-photon emission computed tomography (SPECT) on 15 patients with MD (eight men, seven women, aged 51-78 years, mean 70.5 years) and 11 control subjects (eight men, three women, aged 62-80 years, mean 72.5 years). Regional blood flow was measured in the superior, middle, and inferior portions of the cerebellar hemispheres, and the frontal, temporal and occipital cerebral lobes. The degree of cerebellar atrophy was assessed on MRI. There were significant differences in regional blood flow in all parts of the cerebellum between patients and control, but no significant decrease was observed in the cerebrum. Blood flow was lower in the inferior cerebellum than in the other parts. Even in patients without cerebellar atrophy, flow was significantly decreased regional blood flow in the inferior part.

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Section: Discussionmentioning

confidence: 99%