Decrease in glucose-stimulated insulin secretion following exposure to magnetic fields

Sakurai, Tomonori; Koyama, Satoshi; Komatsubara, Yoshiki; Wang, Jin; Miyakoshi, Junji

doi:10.1016/j.bbrc.2005.04.091

Cited by 20 publications

(11 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have recently reported that exposure to ELFMF at 5 mT attenuated both potassium chlorideand glucose-stimulated insulin secretion [Sakurai et al, 2004[Sakurai et al, , 2005a. The findings in the current investigation would appear to be inconsistent with these previous observations.…”

Section: Discussioncontrasting

confidence: 98%

See 1 more Smart Citation

Exposure to extremely low frequency magnetic fields affects insulin‐secreting cells

Sakurai

Yoshimoto

Koyama

et al. 2007

Bioelectromagnetics

Self Cite

View full text Add to dashboard Cite

To evaluate the effects of extremely low frequency magnetic field (ELFMF) on beta-cell survival and function, we cultured a hamster-derived insulin-secreting cell line (HIT-T15), which exhibits responsiveness to glucose in a semi-physiological range, under exposure to sham and ELFMF conditions, and assessed cell survival and function. We used our previously developed ELFMF exposure unit (a sinusoidal magnetic field at a frequency of 60 Hz, 5 mT) to culture cells under exposure to ELFMF conditions. We found that exposure to ELFMF for 5 days in the absence of glucose increased cell number, exposure for 2 days in the absence of glucose and for 5 days with 100 mg/dl glucose increased the insulin secretion to the culture medium, and exposure for 2 and 5 days with 40 and 100 mg/dl glucose increased intracellular insulin concentration in HIT-T15 cells. The increase in cell number under apoptotic culture conditions by exposure to ELFMF could lead to new therapeutic concepts in the treatment of diabetes. The ELFMF-induced increase in intracellular insulin concentration could be utilized to develop culture conditions to enhance intracellular insulin concentration in insulin-secreting cells that would be useful for cell transplantation to cure diabetes mellitus.

show abstract

Section: Discussioncontrasting

confidence: 98%

“…Most recently, we demonstrated that exposure to ELFMF for 1 or 2 h decreased insulin secretion in vitro [Sakurai et al, 2004[Sakurai et al, , 2005a. In normal rats, long-term exposure to ELFMF has been shown to lead to an increase in plasma insulin concentration [Laitl-Kobierska et al, 2002].…”

Section: Introductionmentioning

confidence: 98%

Exposure to extremely low frequency magnetic fields affects insulin‐secreting cells

Sakurai

Yoshimoto

Koyama

et al. 2007

Bioelectromagnetics

Self Cite

View full text Add to dashboard Cite

show abstract

“…This result is supported by previous data (Hayek et al 1984;Sakurai et al 2005;Chater et al 2006a). Miyakoshi et al (2006) using a system for exposure of cultured cell (ELF 60 Hz, 5 mT, 1 h), showed also a significant decrease in insulin release.…”

Section: Discussionsupporting

confidence: 83%

“…Pierre et al (2008) and Tsuji et al (1996). Other findings showed that blood glucose level was not affected (Sutter et al 1987;Harakawa et al 2005;Mehrshad et al 2007), or decreased (Gorczynska et al 1989;Laitl-Kobierska et al 2002;Sakurai et al 2005) after SMF exposition. We can hypothesize this difference in results by the different strength and/or the duration of exposition to the magnetic field.…”

Section: Discussionmentioning

confidence: 83%

Time-dependent effects of exposure to static magnetic field on glucose and lipid metabolism in rat

Lahbib¹,

Elferchichi²,

Ghodbane³

et al. 2010

gpb

View full text Add to dashboard Cite

Abstract. In the following study, we investigate the effects of static magnetic field (SMF) (128 mT, 1 h/day during 5 or 15 consecutive days) on anthropometric parameters, glucose and lipid metabolism in rats. Exposure to SMF during 5 days induced a decrease (-8%, p < 0.05) in relative liver weight and serum insulin concentration (-56%, p < 0.001), while blood glucose level was increased (+10%, p < 0.001). By contrast, the same treatment failed to alter body weight, relative kidney weight and levels of lactate, cholesterol, triglycerides and phospholipids. Exposure to SMF during 15 days induced a decrease (-15 %, p < 0.001) in body weight, liver weight (-15 %, p < 0.05), insulin concentration (-63%, p < 0.001), plasmatic lactate level (-55%, p < 0.05) and increased glucose (+24%, p < 0.001), cholesterol (+30%, p < 0.01,) and phospholipids levels (+58%, p < 0.001), whereas, triglycerides decreased (-28%, p < 0.001). These results showed that SMF effects on glucose and lipid metabolism are time-dependent.

show abstract

“…We have been studying the effects of magnetic fields on insulin-secreting cells [Sakurai et al, 2004[Sakurai et al, , 2005a[Sakurai et al, ,b, 2008a. Although the effects of static electric field on insulin protein have been reported [Budi et al, 2005], there have been no investigations evaluating the effects of SMF on insulin-secreting cells.…”

Section: Introductionmentioning

confidence: 99%

Effects of strong static magnetic fields used in magnetic resonance imaging on insulin‐secreting cells

Sakurai

Terashima

Miyakoshi

2008

Bioelectromagnetics

Self Cite

View full text Add to dashboard Cite

The magnetic flux density of MRI for clinical diagnosis has been steadily increasing. However, there remains very little biological data regarding the effect of strong static magnetic fields (SMFs) on human health. To evaluate the effects of strong SMFs on biological systems, we cultured insulin-secreting cells under exposure to sham and SMF conditions (3-10 T of magnetic flux density, and 0-41.7 T/m of magnetic field gradient) for 0.5 or 1 h, and analyzed insulin secretion, mRNA expression, glucose-stimulated insulin secretion, insulin content, cell proliferation and cell number. Exposure to SMF with a high magnetic field gradient for 1 h significantly increased insulin secretion and insulin 1 mRNA expression. Exposure to SMF with a high magnetic flux density for 0.5 h significantly enhanced responsiveness to glucose stimulation. Exposure to SMF did not affect the insulin content, cell proliferation or cell number. Our results suggested that MRI systems with a higher magnetic flux density might not cause cell proliferative or functional damages on insulin-secreting cells, and that SMF with a high magnetic field gradient might be used clinically after thorough in vivo investigations are conducted.

show abstract

Decrease in glucose-stimulated insulin secretion following exposure to magnetic fields

Cited by 20 publications

References 22 publications

Exposure to extremely low frequency magnetic fields affects insulin‐secreting cells

Exposure to extremely low frequency magnetic fields affects insulin‐secreting cells

Time-dependent effects of exposure to static magnetic field on glucose and lipid metabolism in rat

Effects of strong static magnetic fields used in magnetic resonance imaging on insulin‐secreting cells

Contact Info

Product

Resources

About