Decrease in HDV endemicity in Italy

Sagnelli, E.; Stroffolini, Tommaso; Ascione, Antonio; Chiaramonte, M.; Craxı̀, Antonio; Giusti, G.; Piccinino, F

doi:10.1016/s0168-8278(97)80004-9

Cited by 80 publications

(56 citation statements)

References 7 publications

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“…For several years, HDV infection has been characterized by a higher prevalence in Southern than in Northern Italian areas [8][9][10][11]. However, since the survey of 2006 [12], the prevalence has become higher in the latter ones.…”

Section: Discussionmentioning

confidence: 99%

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Hepatitis delta infection in Italian patients: towards the end of the story?

et al. 2016

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a sex ratio (M/F) of 2.05. The majority (80.3%) of them was 50 years or older, while the proportion of subjects younger than 30 years of age was as low as 3.3%. No difference was detected by geographical area of residence. The presence of liver cirrhosis was diagnosed in 52.4% of cases. In comparison to previous studies, a further shift towards the oldest age groups and an increasing proportion of subjects having liver cirrhosis among all anti-delta-positive subjects are observed. Conclusions Currently, hepatitis delta infection mostly affects old people who have an advanced but indolent liver disease, reflecting a survival effect. The defective hepatitis delta virus is near to disappear in the country, where it has been discovered in the second half of 70s.

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Section: Discussionmentioning

confidence: 99%

“…Moreover, the present findings have been compared with the corresponding figures from the previous studies [8][9][10][11][12] to detect changes, if any.…”

Section: Introductionmentioning

confidence: 93%

Hepatitis delta infection in Italian patients: towards the end of the story?

et al. 2016

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“…A decrease in HBV, HDV and HCV endemicity in Italy has been shown in the past 2 decades, [29][30][31][32] but the present epidemiologic conditions still call for studies on multiple hepatitis infections.…”

Section: Discussionmentioning

confidence: 99%

Virologic and Clinical Expressions of Reciprocal Inhibitory Effect of Hepatitis B, C, and Delta Viruses in Patients With Chronic Hepatitis

et al. 2000

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Hepatitis B virus (HBV), hepatitis D virus (HDV), and hepatitis C virus (HCV) are responsible for the majority of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC) cases worldwide. 1-4 Multiple HBV and HDV infection has been extensively investigated in past years and found to be associated with a fulminant course of acute hepatitis, with the more severe forms of chronic liver disease, and with a rapid progression to liver cirrhosis. 5-8 An inhibitory effect exerted by HDV on HBV replication has also been shown. 9 The prevalence of patients with HCV and HBV coinfection has been described as high in geographic areas where a high endemic level of both infections is reported, such as Western Asia and the Mediterranean Basin. 10-14 The interaction between HCV and HBV has so far been poorly investigated. Little is known on the clinical presentation, the natural history, and the response to antiviral treatment of liver diseases associated with HBV and HCV coinfection. However, small pilot studies have prompted the hypothesis that HCV may have an inhibitory effect on HBV replication [15][16][17][18][19] and that multiple HBV and HCV infection may be associated with a more severe clinical presentation. 10,[20][21][22][23][24][25] The interaction between HDV and HCV in hepatitis B surface antigen (HBsAg) chronic carriers has not as yet been investigated.In this article we report the data from an Italian multicenter case-control study with incident cases, performed on a high number of patients with chronic hepatitis from a multiple hepatitis virus infection who were compared with patients with chronic hepatitis caused by a single virus. We investigated the interference between viruses, the clinical impact of a multiple virus infection compared with a single HBV or HCV infection, and tested the hypothesis that anti-HCV-positive/ anti-hepatitis B core antigen (HBc)-positive patients lacking both HBsAg and anti-hepatitis B surface antigen (HBs) might be a subgroup of patients with a multiple HBV and HCV infection. MATERIALS AND METHODSPatients. Seven liver units in different geographic areas of Italy, 1 in the north (Padua), 1 in the center (Rome), 2 in the south (Naples and Bari), 1 in Sardinia (Sassari), and 2 in Sicily (Palermo and Messina), participated in the study. These liver units had participated in numerous multicenter studies on chronic hepatitis in the past 2 decades and had been using similar criteria for the clinical approach and the histologic diagnosis. The investigation was planned as a cross-sectional case-control study with incident cases during a preliminary consensus meeting of the senior investigators from the participating centers.Chronic hepatitis was diagnosed on the basis of high serum transaminase values for at least 6 months.

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“…Ele possui notável poder de dominância e supressão sobre outros agentes virais, observando-se, por exemplo, o seu efeito dominante na coinfecção com o VHB e na tripla infecção com o VHB + VHC 44 . O VHD apresenta também efeito inibitório sobre a síntese dos antígenos virais do VHB durante a superinfecção, particularmente sobre o antígeno de superfície (HBsAg) e o antígeno central (HBcAg) 42 .…”

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Hepatite D

Fonseca

2002

Rev. Soc. Bras. Med. Trop.

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Resumo O vírus da hepatite D (VHD), também chamado de vírus delta, é um pequeno vírus contendo RNA circular. O VHD causa infecção, quando há coinfecção com o vírus da hepatite B (VHB) em indivíduos normais ou superinfecção em portadores crônicos do VHB. Três genótipos já foram clonados e seqüenciados. A infecção apresenta distribuição mundial, sendo a região ocidental da Amazônia brasileira considerada área de alta endemicidade. Estima-se que 18 milhões de pessoas encontram-se infectadas pelo vírus entre os 350 milhões de portadores crônicos do VHB no mundo. As vias de transmissão do VHD e os fatores de risco mostram-se similares aos da infecção pelo VHB. O diagnóstico se faz pela identificação imuno-histológica do HDAg no fígado e pelo encontro das frações IgM e IgG anti-HD no soro por radioimunoensaio ou ELISA. O curso clínico da infecção pelo VHD mostra-se variável. Os pacientes podem apresentar formas fulminantes de hepatite. As formas crônicas associam-se a achados histopatológicos graves no fígado, com curso rápido e progressivo, evoluindo para cirrose, insuficiência hepática e morte. O interferon alfa constitui a única opção terapêutica com algum efeito benéfico no tratamento da hepatite. O transplante hepático encontra indicação nos casos terminais de cirrose. A profilaxia indireta da infecção pelo VHD tornou-se possível com o advento da vacina contra o vírus da hepatite B. 42 . Em tripla infecção viral, a infecção pelo VHD associa-se à supressão da viremia do VHB e do vírus da hepatite C, sendo maior no VHC do que no VHB 23 .

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Decrease in HDV endemicity in Italy

Cited by 80 publications

References 7 publications

Hepatitis delta infection in Italian patients: towards the end of the story?

Hepatitis delta infection in Italian patients: towards the end of the story?

Virologic and Clinical Expressions of Reciprocal Inhibitory Effect of Hepatitis B, C, and Delta Viruses in Patients With Chronic Hepatitis

Hepatite D

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