2013
DOI: 10.1152/ajprenal.00343.2013
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Decrease in neuronal nicotinic acetylcholine receptor subunit and PSD-93 transcript levels in the male mouse MPG after cavernous nerve injury or explant culture

Abstract: Girard BM, Merriam LA, Tompkins JD, Vizzard MA, Parsons RL. Decrease in neuronal nicotinic acetylcholine receptor subunit and PSD-93 transcript levels in the male mouse MPG after cavernous nerve injury or explant culture. Am J Physiol Renal Physiol 305: F1504 -F1512, 2013. First published September 18, 2013 doi:10.1152/ajprenal.00343.2013.-Quantitative real-time PCR was used to test whether cavernous nerve injury leads to a decrease in major pelvic ganglia (MPG) neuronal nicotinic ACh receptor (nAChR) subunit… Show more

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Cited by 9 publications
(7 citation statements)
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“…An overlap in the receptor expression between α 7 and α 3 β 4 * nAChRs, in particular within autonomic neurons [50,51], necessitates the investigation of the selectivity of potential ligands. By comparing data obtained for compounds 10a and 10b ( K i : 119 nM and 43 nM) with the affinity values of the corresponding compounds 7c and 7a reported by Gao et al , ( K i : 5000 nM and 709 nM) [17], species-specific differences become obvious.…”
Section: Resultsmentioning
confidence: 99%
“…An overlap in the receptor expression between α 7 and α 3 β 4 * nAChRs, in particular within autonomic neurons [50,51], necessitates the investigation of the selectivity of potential ligands. By comparing data obtained for compounds 10a and 10b ( K i : 119 nM and 43 nM) with the affinity values of the corresponding compounds 7c and 7a reported by Gao et al , ( K i : 5000 nM and 709 nM) [17], species-specific differences become obvious.…”
Section: Resultsmentioning
confidence: 99%
“…These features are likely driven by neuronal dysfunction, as nicotinic receptors are expressed by autonomic ganglion neurons and required for transmitting the excitatory message from spinal neurons to ganglion cells, and hence to the organs. Specifically, Chrna3 and Chrnb4 are highly expressed in pelvic ganglia (Park et al, 2006 ; Girard et al, 2013 ) and are upregulated in parasympathetic pelvic ganglion neurons in a surgical obstruction model of the urethra (Chung et al, 2015 ). While not excluding other mechanisms, these reports are consistent with the bladder dysfunction being driven by an inability to void, resulting in distension and hypertrophy of the bladder.…”
Section: Genetic Models Of Bladder Dysfunctionmentioning
confidence: 99%
“…The samples were consolidated for subsequent analysis. Transcript levels for Cav2.3 were determined from extracts of cardiac ganglia whole mounts collected under RNase-free conditions (17).…”
Section: Animalsmentioning
confidence: 99%