Decrease in outpatient department visits and operative interventions due to bisphosphonates in children with osteogenesis imperfecta

Graaff, Fuusje de; Verra, Wiebe C.; Pruijs, J. E. H.; Sakkers, R. J. B.

doi:10.1007/s11832-010-0305-3

Cited by 13 publications

(10 citation statements)

References 17 publications

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“…Graaff ve ark. 118 hastada bifosfonat tedavisini uygulamış ve kırık oluşumunu engellemede ve kırık iyileşmesinde bu tedavinin anlamlı katkısının olduğunu göstermişlerdir (4). Takiplerde kırıkların iyileşmesiyle birlikte deformiteler de görülebilmektedir.…”

Section: Discussionunclassified

“…In this paper, the treatment of fractures and deformity correction in patients with osteogenesis imperfecta using locked intramedullary nailing technique is discussed in the light of the literature. Genel tedavi yaklaşımları arasında ilaç tedavisi (bifosfonatlar, büyüme hormonları, analjezikler), alçı uygulamaları, brace uygulamaları yer almaktadır (3,4). Osteopeni ve korteksteki incelme kırıkların tedavisini de zorlaştırmaktadır.…”

Section: Introductionunclassified

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Osteogenezis İmperfektalı Hastada İntramedüller Çivi ile Kırık ve Deformite Tedavisi

Göçer¹,

Ulusoy²,

Çıraklı³

et al. 2014

Haseki

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ÖzetOsteogenezis imperfekta kemik kırılganlığında artış ile karakterize kalıtımsal bir hastalıktır. Tip I kollagen üretimi ve endokondriyal kemik gelişim bozukluğu görülmektedir. İskelet sistemi dışında bir çok organı da etkileyen sistemik bir sendrom olarak da kabul edilir. Olgumuzda tip I osteogenezis imperfekta tanısı konulan 13 yaşındaki bir çocuğun sol femurunda minör travma sonrası gelişen fraktürün tedavisinin, aynı kemikteki deformite ile eş zamanlı olarak kilitli intramedüller çivileme yöntemi ile düzeltilmesi anlatılmıştır. Ayrıca hastanın sağ femurundaki benzer deformite üç aylık aradan sonra aynı teknikle düzeltilmiştir. Yazımızda osteogenezis imperfekta tanısı alan hastaların kırık ve deformitelerinin düzeltilmesinde kilitli intramedüller çivileme tekniği literatür eşliğinde tartışılmıştır. (Ha se ki T›p Bül te ni 2014; 52: 126-9) Anahtar Sözcükler: Osteogenezis imperfekta, kırık, deformite, intramedüller çivi Abs tractOsteogenesis imperfecta is a hereditary disorder characterized by increased bone fragility. The production of type I collagen and endochondral bone development are disturbed. The disease is also considered a systemic syndrome affecting several organs besides skeletal system. Here, we present a case of osteogenesis imperfecta in a 13-year-old child with femoral fracture after a minor trauma on his left femur and ipsilateral deformity that were treated simultaneously by locked intramedullary nailing. Furthermore, the deformity on the right femur was treated using the same technique three months later. In this paper, the treatment of fractures and deformity correction in patients with osteogenesis imperfecta using locked intramedullary nailing technique is discussed in the light of the literature. (The Me di cal Bul le tin of Ha se ki 2014; 52: 126-9)

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Section: Discussionunclassified

Section: Introductionunclassified

Osteogenezis İmperfektalı Hastada İntramedüller Çivi ile Kırık ve Deformite Tedavisi

Göçer¹,

Ulusoy²,

Çıraklı³

et al. 2014

Haseki

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“…14 Overall, bisphosphonate treatment is associated with a reduction of the number of outpatient department consultations and operative interventions. 41 The effects of bisphosphonates seem to be amplified by the growth process, but do not appear to vary much with OI type. Even though OI types I, III and IV constitute the large majority of patients studied until now, responses to pamidronate treatment were observed also in OI types V to VII, even though fracture incidence remained relatively high in OI type VI.…”

Section: Effects Of Intravenous Pamidronatementioning

confidence: 99%

Bisphosphonate Treatment and Related Agents in Children

Rauch

2014

Osteogenesis Imperfecta

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“…Improved bone quality with pamidronate treatment allows better stability of rods in the bone, and improved design of rods reduces the rate of mechanical complications [34] and Graff et al [35] shown that bisphosphonates can significantly reduce the number of outpatient department consultations and operative interventions in patients with OI.…”

Section: Tablementioning

confidence: 99%

The Use of Kirschner Wire Intramedullary in Pediatric Femur Fractures with Osteogenesis Imperfecta

Hưng

Tan

Hien

2016

International Journal of Orthopaedics

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BACKGROUND: Surgical treatment for osteogenesis imperfecta (OI) remains controversial. The use of nonelongating rods is considered to be the classic method. This older method is still used by surgeons who are concerned about the possibility of trauma or who are working in developing countries with fewer resources. We are among those who prefer the use of Kirschner wire (K-W). This article presents the results of intramedullary fixation using K-W and Bisphosphonate treament in children with OI and the proper timing of wire exchange to prevent further fracture. METHODS: We treated 29 femora in 24 patients with OI by means of stabilization using K-W. The patients divided two Variant: (1) Variant 1: femoral fractures fixed by K-W only (10 patients); (2) Variant 2: femoral fractures fixed by K-W and combined treated with bisphosphonates (14 patients). Sillence classification of OI with 4 Types and the features: Type I: Osseous fragility, Adulthood hearing loss, Blue sclera; Type II: Extremety severe osseous fragility, Perinatally lethal; Type III: Moderate to severe osseous fragility, Normal sclera, Severe deformity of the long bones and spine, Variable clinical and radiographic phenotypes; Type IV: Osseous fragility, General normal sclera, Severe deformity of long bones and spine. Our Surgical treatment for acute fracture and for angular deformity correction if present on patients with OI is based on the classic Sofield-Millar technique, evaluating treatment according to El Sobky. RESULTS: Indications for the primary surgery included: fracture were 4 fracture only, and Fracture and deform were 25. There were 24 Patients, Right/left/Bilateral fracture femur in 12/7/5; Total fracture femur 29. There were 45.8% in Type 1, 33.4% in Type 3, and 20.8% in Type 4. The male to female ratio was 1: 1.7. There were 5 (20.8%) patients with family history. The mean age at the primary procedure for K-W was 27.9 months old (range, 18-43 months old). The mean follow-up period was 75.5 months (range, 62 months to 89 months). In this study, Variant 2 (accepted was 57.1%) better than Variant 1 (accepted was 20%). CONCLUSIONS: Documented that children treated with Bisphosphonate prior to surgery and afterwards do better than children treated with surgery alone. We suggested that a surgical treatment using non-extensible nails is indicated when complications such as fractures and/ or deformities are present, based on the fact that these nails do not follow bone growth, if early implanted, complications will eventually occur, resulting in a larger number of review surgeries.

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Decrease in outpatient department visits and operative interventions due to bisphosphonates in children with osteogenesis imperfecta

Cited by 13 publications

References 17 publications

Osteogenezis İmperfektalı Hastada İntramedüller Çivi ile Kırık ve Deformite Tedavisi

Osteogenezis İmperfektalı Hastada İntramedüller Çivi ile Kırık ve Deformite Tedavisi

Bisphosphonate Treatment and Related Agents in Children

The Use of Kirschner Wire Intramedullary in Pediatric Femur Fractures with Osteogenesis Imperfecta

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