Decrease in sweet taste response and T1R3 sweet taste receptor expression in pregnant mice highlights a potential mechanism for increased caloric consumption in pregnancy

Choo, Ezen; Koh, Anna P.; Goodman, Jason; Bushnell, Jennifer; Mielke-Maday, Hanna; Merte, Bryan; Dando, Robin

doi:10.1016/j.physbeh.2020.113191

Cited by 7 publications

(4 citation statements)

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“…could also be due to alterations in taste sensitivity. In humans and mice, it has been shown that taste changes during the course of pregnancy and in the postpartum www.nature.com/scientificreports/ period 59,60 . Some authors suggested that these alterations could be due to hormonal changes occurring relative to parturition [59][60][61] .…”

Section: Figurementioning

confidence: 99%

“…In humans and mice, it has been shown that taste changes during the course of pregnancy and in the postpartum www.nature.com/scientificreports/ period 59,60 . Some authors suggested that these alterations could be due to hormonal changes occurring relative to parturition [59][60][61] . The ability to modify taste has been demonstrated for leptin 62 , oxytocin 63 and estrogen 64 in rodents, but the influence of hormonal changes occurring in the peripartum period on taste sensitivity in cattle remains unclear.…”

Section: Figurementioning

confidence: 99%

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Endocannabinoid administration affects taste preference and the expression of cannabinoid and opioid receptors in the amygdala of early lactating cows

Schwerdtfeger

Krause

Kalbe

et al. 2023

Sci Rep

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The aim of the study was to investigate the influence of intraperitoneal N-arachidonoylethanolamide (AEA) on taste preference for feed and water, tongue taste receptor signalling (TAS1R2, GNAT3), and endocannabinoid (CNR1, CNR2, GPR55) and opioid (OPRD1, OPRK1, OPRM1, OPRL1) receptors in the amygdala and nucleus accumbens in periparturient cows. We conducted taste preference tests using unaltered, umami-tasting, and sweet-tasting water and feed, before and after calving. After calving, eight cows received AEA injections (3 µg/(kg bodyweight × day), 25 days), whereas eight control (CON) cows received saline injections. Tissue was sampled 30 days after calving. Before calving, both cow groups preferred sweet-tasting feed and umami-tasting water. After calving, only the AEA-treated group preferred sweet-tasting feed, whereas the CON group showed no clear taste preference. In the amygdala, the mRNA expression of CNR1, OPRD1 (left hemisphere) and OPRK1 (right hemisphere) was lower in AEA animals than in CON animals, whereas no differences were found in the nucleus accumbens and tongue taste receptor expression. In conclusion, AEA administration enhanced existing taste preferences and reduced the expression of specific endocannabinoid and opioid receptors in the amygdala. The results support endocannabinoid-opioid interactions in the control of taste-dependent feed preference in early lactating cows.

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Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Endocannabinoid administration affects taste preference and the expression of cannabinoid and opioid receptors in the amygdala of early lactating cows

Schwerdtfeger

Krause

Kalbe

et al. 2023

Sci Rep

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show abstract

“…For example, expression of the lipid sensor FFAR2 in pancreatic islets was higher on day 15 of pregnancy, compared with nonpregnant mice (53). Furthermore, transcripts for the lingual nutrient sensor for “umami,” the taste receptor subunit T1R1, were elevated in the tongue at midpregnancy in mice, whereas there were no changes in sweet taste subunits T1R2 or T1R3 across pregnancy stages (54). Altered expression of T1R1 may be important for altered taste perception and promotion of specific nutrient intake, such as protein (1), as well as overall food intake.…”

Section: Changes In Food Intake Regulation During Pregnancymentioning

confidence: 99%

Maternal adaptations to food intake across pregnancy: Central and peripheral mechanisms

Clarke

Gatford

Young

et al. 2021

Obesity

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A sufficient and balanced maternal diet is critical to meet the nutritional demands of the developing fetus and to facilitate deposition of fat reserves for lactation. Multiple adaptations occur to meet these energy requirements, including reductions in energy expenditure and increases in maternal food intake. The central nervous system plays a vital role in the regulation of food intake and energy homeostasis and responds to multiple metabolic and nutrient cues, including those arising from the gastrointestinal tract. This review describes the nutrient requirements of pregnancy and the impact of over‐ and undernutrition on the risk of pregnancy complications and adult disease in progeny. The central and peripheral regulation of food intake is then discussed, with particular emphasis on the adaptations that occur during pregnancy and the mechanisms that drive these changes, including the possible role of the pregnancy‐associated hormones progesterone, estrogen, prolactin, and growth hormone. We identify the need for deeper mechanistic understanding of maternal adaptations, in particular, changes in gut–brain axis satiety signaling. Improved understanding of food intake regulation during pregnancy will provide a basis to inform strategies that prevent maternal under‐ or overnutrition, improve fetal health, and reduce the long‐term health and economic burden for mothers and offspring.

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“…Dietary changes are common in pregnant women and may be influenced by factors, such as food aversions, cravings, time needed to prepare foods, and finances [ 13 ]. Indeed, some women crave certain food types, including carbohydrate- and fat-rich diets while expecting [ 14 ]. Despite this, the impacts of consuming a high fat and high sugar diet during pregnancy on fetal and offspring outcomes are poorly defined [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Obesogenic diet in pregnancy disrupts placental iron handling and ferroptosis and stress signalling in association with fetal growth alterations

Zaugg,

Lopez-Tello,

Musial

et al. 2024

Cell. Mol. Life Sci.

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Obesity and gestational diabetes (GDM) impact fetal growth during pregnancy. Iron is an essential micronutrient needed for energy-intense feto-placental development, but if mis-handled can lead to oxidative stress and ferroptosis (iron-dependent cell death). In a mouse model showing maternal obesity and glucose intolerance, we investigated the association of materno-fetal iron handling and placental ferroptosis, oxidative damage and stress signalling activation with fetal growth. Female mice were fed a standard chow or high fat, high sugar (HFHS) diet during pregnancy and outcomes were measured at day (d)16 or d19 of pregnancy. In HFHS-fed mice, maternal hepcidin was reduced and iron status maintained (tissue iron levels) at both d16 and d19. However, fetal weight, placental iron transfer capacity, iron deposition, TFR1 expression and ERK2-mediated signalling were reduced and oxidative damage-related lipofuscin accumulation in the placenta was increased in HFHS-fed mice. At d19, whilst TFR1 remained decreased, fetal weight was normal and placental weight, iron content and iron transporter genes (Dmt1, Zip14, and Fpn1) were reduced in HFHS-fed mice. Furthermore, there was stress kinase activation (increased phosphorylated p38MAPK, total ERK and JNK) in the placenta from HFHS-fed mice at d19. In summary, a maternal HFHS diet during pregnancy impacts fetal growth trajectory in association with changes in placental iron handling, ferroptosis and stress signalling. Downregulation of placental iron transporters in HFHS mice may protect the fetus from excessive oxidative iron. These findings suggest a role for alterations in placental iron homeostasis in determining perinatal outcomes of pregnancies associated with GDM and/or maternal obesity. Graphical Abstract

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Decrease in sweet taste response and T1R3 sweet taste receptor expression in pregnant mice highlights a potential mechanism for increased caloric consumption in pregnancy

Cited by 7 publications

References 50 publications

Endocannabinoid administration affects taste preference and the expression of cannabinoid and opioid receptors in the amygdala of early lactating cows

Endocannabinoid administration affects taste preference and the expression of cannabinoid and opioid receptors in the amygdala of early lactating cows

Maternal adaptations to food intake across pregnancy: Central and peripheral mechanisms

Obesogenic diet in pregnancy disrupts placental iron handling and ferroptosis and stress signalling in association with fetal growth alterations

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