Decrease of Johne’s disease prevalence and incidence in six Minnesota, USA, dairy cattle herds on a long-term management program

Ferrouillet, Cécile; Wells, Scott J.; Hartmann, Welington; Godden, Sandra; Carrier, J.

doi:10.1016/j.prevetmed.2008.08.001

Cited by 37 publications

(32 citation statements)

References 18 publications

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“…It is important to note that the authors also concluded that a small chance (<0.15) of MAP persistence due to vertical transmission exists (Lu et al, 2013). Therefore, it is likely that Johne's disease eradication must encompass vaccination under the umbrella of a well-defined control program that includes standard management practices for rapid detection, hygiene, separation of newborns from adults, and culling of infected animals (Ferrouillet et al, 2009; Espejo et al, 2012). …”

Section: Introductionmentioning

confidence: 99%

Screening of Mycobacterium avium subsp. paratuberculosis mutants for attenuation in a bovine monocyte-derived macrophage model

Lamont

Talaat

Coussens

et al. 2014

Front. Cell. Infect. Microbiol.

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Vaccination remains a major tool for prevention and progression of Johne's disease, a chronic enteritis of ruminants worldwide. Currently there is only one licensed vaccine within the United States and two vaccines licensed internationally against Johne's disease. All licensed vaccines reduce fecal shedding of Mycobacterium avium subsp. paratuberculosis (MAP) and delay disease progression. However, there are no available vaccines that prevent disease onset. A joint effort by the Johne's Disease Integrated Program (JDIP), a USDA-funded consortium, and USDA—APHIS/VS sought to identify transposon insertion mutant strains as vaccine candidates in part of a three phase study. The focus of the Phase I study was to evaluate MAP mutant attenuation in a well-defined in vitro bovine monocyte-derived macrophage (MDM) model. Attenuation was determined by colony forming unit (CFUs) counts and slope estimates. Based on CFU counts alone, the MDM model did not identify any mutant that significantly differed from the wild-type control, MAP K-10. Slope estimates using mixed models approach identified six mutants as being attenuated. These were enrolled in protection studies involving murine and baby goat vaccination-challenge models. MDM based approach identified trends in attenuation but this did not correlate with protection in a natural host model. These results suggest the need for alternative strategies for Johne's disease vaccine candidate screening and evaluation.

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Section: Introductionmentioning

confidence: 99%

Screening of Mycobacterium avium subsp. paratuberculosis mutants for attenuation in a bovine monocyte-derived macrophage model

Lamont

Talaat

Coussens

et al. 2014

Front. Cell. Infect. Microbiol.

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show abstract

“…paratuberculosis shedding into the environment, because of the positive correlation of antibody titers and fecal shedding in infected cows (15,16). This concept is incorporated in Johne's disease control programs, as well (30,31). However, in this study, no such direct effect was observed.…”

Section: Discussionmentioning

confidence: 60%

Relationship between Presence of Cows with Milk Positive for Mycobacterium avium subsp. paratuberculosis-Specific Antibody by Enzyme-Linked Immunosorbent Assay and Viable M. avium subsp. paratuberculosis in Dust in Cattle Barns

Eisenberg

Chuchaisangrat

Nielen

et al. 2013

Appl Environ Microbiol

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“…4 Although it may be of interest to test how effective Dietzia would be in curtailing this type exposure, such a group was not included because it can and should be controlled by management practices as defined by others. 11,[16][17][18][19][20][21][22][23] The only calves found positive as adults for parameters indicative of MAP infection were those whose dams were positive for Johne's disease. Of 51 calves from paratuberculosis-negative dams (10 not treated, 36 treated with Dietzia for 60 days and five in either treatment Groups 2 or 4), none tested positive for any Johne's disease-associated parameter.…”

Section: Discussionmentioning

confidence: 99%

A 60-day probiotic protocol withDietziasubsp.C79793-74prevents development of Johne's disease parameters after in utero and/or neonatalMAPinfection

Click

2011

Virulence

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The research reported herein was designed to assess whether the bacterium, Dietzia subspecies C79793-74, used as a probiotic, could prevent development of parameters indicative of bovine paratuberculosis after potential in utero, birthing and neonatal (colostrum) exposure to Mycobacterium avium subspecies paratuberculosis (MAP). Such exposure avenues are especially relevant for dairy farms practicing good management procedures since calves on these farms could be infected via dams that have yet to be identified as MAP-positive. Indeed, of 18 calves in the present study that became paratuberculosis parameter-positive, five had dams that were negative for all parameters pre-calving. Parameters used herein to define paratuberculosis status were serum ELISA, serum agar gel immunodiffusion, cultureable fecal MAP, histopathology at necropsy and clinical disease. Thirty-four newborn calves, whose dams were paratuberculosis-positive, were assigned to four different treatment groups. Ten were treated daily for 60 days with viable Dietzia added to their antibiotic-free milk feedings; none became positive for any parameter with age. In contrast, seven of eight calves that were not treated became positive for one or more paratuberculosis-associated parameter. Sixteen calves were treated with viable Dietzia for the first two days of life; eight were then not treated further, whereas the other eight were treated an additional 58 days with Dietzia added to tetracycline-fortified milk (Dietzia is sensitive to tetracycline). In these two groups, positivity developed in five of eight and six of eight, respectively. These results indicated that (a) a daily, 60-day treatment with viable Dietzia effectively prevented development of parameters indicative of paratuberculosis and (b) this treatment, in combination with good management practices, has the potential to eradicate MAP from animals/herds, which should curtail the spread of MAP. Such results should significantly reduce human exposure to MAP, which in turn, could have relevance for the controversial role of MAP in Crohn's disease, type-1 diabetes mellitus, sarcoidosis, Blau syndrome, ulcerative colitis, irritable bowel syndrome and multiple sclerosis.

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Decrease of Johne’s disease prevalence and incidence in six Minnesota, USA, dairy cattle herds on a long-term management program

Cited by 37 publications

References 18 publications

Screening of Mycobacterium avium subsp. paratuberculosis mutants for attenuation in a bovine monocyte-derived macrophage model

Screening of Mycobacterium avium subsp. paratuberculosis mutants for attenuation in a bovine monocyte-derived macrophage model

Relationship between Presence of Cows with Milk Positive for Mycobacterium avium subsp. paratuberculosis-Specific Antibody by Enzyme-Linked Immunosorbent Assay and Viable M. avium subsp. paratuberculosis in Dust in Cattle Barns

A 60-day probiotic protocol withDietziasubsp.C79793-74prevents development of Johne's disease parameters after in utero and/or neonatalMAPinfection

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