Decrease of Platelet Activity After Intake of Small Amounts of Eicosapentaenoic Acid in Diabetics

Velardo, B.; Lagarde, Michel; Guichardant, Michel; Dechavanne, M; Beylot, M.; Sautot, G; Berthezéne, F

doi:10.1055/s-0038-1657299

Cited by 24 publications

(4 citation statements)

References 8 publications

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“…This is despite numerous studies in which fish oil supplementation has been examined in both non-insulin-dependent diabetic (NIDDM; [10][11][12][13] and IDDM subjects (14)(15)(16)(17). The most consistent Serum lipids in patients without retinopathy (A; n = 10) and with retinopathy (B; n = 6) during baseline, after 3 wk treatment with Max EPA, and 6 wk after ceasing Max EPA.…”

Section: Discussionmentioning

confidence: 99%

“…However, when a greater quantity of w3FA was used, there was a decrease in total cholesterol (12). Small quantities of co3FA (<1 g EPA/day) had no effect on cholesterol and lipoproteins in both NIDDM and IDDM subjects (13)(14)(15).…”

Section: Effect Of Max Epa On Apolipoproteins (Apo) A-l A-ll and B mentioning

confidence: 90%

“…Changes in apolipoproteins have not, with the exception of apoB, been described (4,11,18,20). Results from studies in which fish oils have been given to diabetic subjects are somewhat varied (10)(11)(12)(13)(14)(15)(16)(17). In patients with NIDDM consuming 12 g/day Max EPA for 4 wk, the levels of total cholesterol and LDL-chol were unaffected, although apoB was increased (11).…”

Section: Effect Of Max Epa On Apolipoproteins (Apo) A-l A-ll and B mentioning

confidence: 99%

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Fish Oil–Induced Changes in Apolipoproteins in IDDM Subjects

Mori

Vandongen²,

Masarei³

1990

Diabetes Care

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The aim of this study was to examine the effect of Max EPA (a commercially available fish oil preparation) on serum cholesterol lipoproteins and apolipoproteins in insulin-dependent diabetic (IDDM) men with dosages that were likely to be acceptable to patients. Twenty-two male IDDM patients aged 20-41 yr, 6 of whom had retinopathy, were recruited from the Royal Perth Hospital diabetic clinic. After screening, subjects were divided into three groups. Six of the subjects without retinopathy were randomly selected and allocated to a control group. The remaining 16 patients (10 without and 6 with retinopathy) received a fish oil supplement. All subjects were advised to maintain their usual dietary patterns. Sixteen patients, including the 6 with retinopathy, were instructed to take 15 Max EPA fish oil capsules/day with meals. Patients in the control group did not take Max EPA. Three weeks of Max EPA supplementation without other dietary modification led to a significant rise in total cholesterol (P less than 0.01), which could be accounted for by increases in low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol. The increase in HDL cholesterol was explained by a 33% rise (P less than 0.001) in its HDL2 subclass. Changes in apolipoproteins were examined and showed that the level of apolipoprotein A-I increased after ingestion of fish oil and correlated significantly (P less than 0.05) with the rise in HDL cholesterol.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

Section: Effect Of Max Epa On Apolipoproteins (Apo) A-l A-ll and B mentioning

confidence: 90%

Section: Effect Of Max Epa On Apolipoproteins (Apo) A-l A-ll and B mentioning

confidence: 99%

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Fish Oil–Induced Changes in Apolipoproteins in IDDM Subjects

Mori

Vandongen²,

Masarei³

1990

Diabetes Care

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“…One of these metabolites, eicosapentaenoic acid (EPA; 20:5 n3), is a precursor of the trienoic PGs. Small amounts of EPA may have significant effects on PG production in vivo [25]. EPA is a potent competitive inhibitor of AA for PG synthetase and for the lipoxygenase that initiates LT synthesis [26][27][28].…”

Section: Efa Metabolism In Atopic Eczemamentioning

confidence: 99%

Increased requirements for essential fatty acids in atopic individuals: a review with clinical descriptions.

Galland¹

1986

Journal of the American College of Nutrition

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Patients with atopic eczema and a mixture of allergic illnesses show biochemical evidence suggesting impairment in the desaturation of linoleic acid and linolenic acid by the enzyme delta-6 dehydrogenase. Consequences of this enzyme defect are 1) diminished synthesis of the 20-carbon polyunsaturated fatty acids, which are prostaglandin precursors and 2) a reduction in the concentration of double bonds in the cell membrane. A distortion in the production of prostaglandins and leukotrienes, which might result from this block, can account for the immunological defects of atopy and a variety of clinical symptoms experienced by atopic individuals. Dietary supplementation with essential fatty acids relieves the signs and symptoms of atopic eczema, may improve other types of allergic inflammation, and may also correct coexisting symptoms as diverse as excessive thirst and dysmenorrhea. Further research is suggested to test the hypothesis that some atopic states represent a condition of essential fatty acid dependency owing to defective desaturation of dietary fatty acids.

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Omega-3 Fatty Acids in Other Diseases

Nettleton

1995

Omega-3 Fatty Acids and Health

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Decrease of Platelet Activity After Intake of Small Amounts of Eicosapentaenoic Acid in Diabetics

Cited by 24 publications

References 8 publications

Fish Oil–Induced Changes in Apolipoproteins in IDDM Subjects

Fish Oil–Induced Changes in Apolipoproteins in IDDM Subjects

Increased requirements for essential fatty acids in atopic individuals: a review with clinical descriptions.

Omega-3 Fatty Acids in Other Diseases

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