Decreased Alpha-Fetoprotein Concentration in Neonatal Pigs after Injection of Adult Swine Serum

Carlsson, Roland; Ingvarsson, Bengt I.

doi:10.1159/000241014

Neonatology

1977

DOI: 10.1159/000241014

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Decreased Alpha-Fetoprotein Concentration in Neonatal Pigs after Injection of Adult Swine Serum

Roland Carlsson¹,

Bengt I. Ingvarsson²

Abstract: Repeated intraperitoneal injections of adult swine serum lead to reduced concentrations of α-fetoprotein (AFP) in neonatal pigs. This is interpreted to be due to suppression of the synthesis of AFP by a factor(s) present in the serum of adult swine although its mode of action remains unclear.

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1980

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Endogenous Clearance Rate and Synthesis of Alphafoetoprotein During and After Blood Exchange Transfusion in Hyperbilirubinaemic Newborns

Teppo

Simell

1980

Acta Paediatrica

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Plasma alphafoetoprotein (AFP) concentration was monitored in 22 hyperbilirubinaemic infants during blood exchange transfusion at the age of 0-4 days, in order to determine the endogenous clearance rate and demonstrate possible postnatal synthesis of AFP. The rapid fall in plasma AFP during the transfusion to 19 +/- 4% (mean +/- S.D.) was followed by an increase to 81 +/- 15% of the initial concentration; only a 68% rise was expected after the establishment of a new equilibrium between the intra- and extravascular pools of AFP. Repeated transfusion in the same individuals gave similar findings. In two infants the total amount of AFP in these pools increased by 4.0-7.4 mg after the transfusions. The results could be accounted for by postnatal AFP synthesis. Because of the diffusion of AFP from the extravascular compartment to the intravascular pool the actual turnover rate of AFP could not be measured. The estimated magnitude of endogenous turnover rate of AFP, 0.02-0.09 min-1, gave a mean half-life of about 20 min, which is distinctly shorter than that of AFP in plasma (3-5 days); this could be due to either continuous synthesis of AFP or transfer of presynthesized AFP from the liver cells to extracellular pool. We postulate that either the synthesis or the turnover rate of AFP is controlled by the plasma AFP concentration via a negative feedback mechanism.

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Endogenous Clearance Rate and Synthesis of Alphafoetoprotein During and After Blood Exchange Transfusion in Hyperbilirubinaemic Newborns

Teppo

Simell

1980

Acta Paediatrica

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Decreased Alpha-Fetoprotein Concentration in Neonatal Pigs after Injection of Adult Swine Serum

Cited by 1 publication

References 10 publications

Endogenous Clearance Rate and Synthesis of Alphafoetoprotein During and After Blood Exchange Transfusion in Hyperbilirubinaemic Newborns

Endogenous Clearance Rate and Synthesis of Alphafoetoprotein During and After Blood Exchange Transfusion in Hyperbilirubinaemic Newborns

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