Decreased bioavailability of vitamin D in obesity

Wortsman, Jacobo; Matsuoka, Lois Y.; Chen, Thomas; Zhang, Lu; Holick, Michael F.

doi:10.1093/ajcn/72.3.690

Cited by 2,790 publications

(2,267 citation statements)

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“…In 2011, the UK Scientific Advisory Committee on Nutrition decided, based on new data, including the IOM report of Dietary Reference Values, that there is now sufficient evidence for an update on vitamin D, which is expected June 2014 [3]. As previously discussed, an inverse relationship between circulating levels of 25OHD and measures of adiposity has been reported, most probably due to the storage of cutaneously synthesized D 3 , the 25OHD precursor, in subcutaneous adipose tissue [17,18]. In the current study there was an increase in BMI at booking in the T1DM group vs. control group ( Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…The most likely mechanism underlying this, is the ability of subcutaneous fat to sequester cutaneously synthesized D 3 [18], the 25OHD precursor. While it has been speculated that vitamin D deficiency may be causal in the development of adiposity and, potentially, its co-morbidities, a recent study using genetic markers as instrumental variables in bi-directional Mendelian randomization analysis has provided evidence that a higher BMI leads to lower 25OHD and that the likelihood of lower 25OHD increasing BMI is small [19].…”

Section: Introductionmentioning

confidence: 99%

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Maternal vitamin D status in Type 1 diabetic pregnancy: Impact on neonatal vitamin D status and association with maternal glycaemic control

Bennett

McPeake

McCance

et al. 2014

Pregnancy Hypertension: An International Journal of Women's Car

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Objective: The first aim of this study was to assess 25-hydroxy vitamin D (25OHD) concentrations in women with type 1 diabetes (T1DM) during pregnancy, post-delivery and also foetal (cord blood) 25OHD concentrations and to examine relationships between these. The second aim of the study was to investigate potential interactions between maternal body mass index (BMI) and foetal vitamin D status. A further study aim was to examine potential relationships between maternal 25OHD and glycosylated haemoglobin (HbA 1c ) throughout pregnancy. Research Design and Methods:This was an observational study of 52 pregnant controls without diabetes and 65 pregnant women with T1DM in a university teaching hospital. Maternal serum 25OHD was measured serially throughout the pregnancy and post-delivery. Cord blood 25OHD was measured at delivery. 25OHD was measured by liquid chromatography tandem mass spectrometry (LC-MS/MS).Results: Vitamin D deficiency (25OHD ,25 nmol/L) was apparent in both the T1DM subjects and controls at all 3 pregnancy trimesters. Vitamin D levels in all cord blood were ,50 nmol/L. Maternal 25OHD correlated positively with cord 25OHD at all 3 trimesters in the T1DM group (p = 0.02; p,0.001; p,0.001). 25OHD levels within cord blood were significantly lower for women with diabetes classified as obese vs. normal weight at booking [normal weight BMI ,25 kg/m 2 vs. obese BMI .30 kg/m 2 (nmol/L6SD); 19.93611.15 vs. 13.7364.74, p = 0.026]. In the T1DM group, HbA 1c at booking was significantly negatively correlated with maternal 25OHD at all 3 trimesters (p = 0.004; p = 0.001; p = 0.05). Conclusion:In T1DM pregnancy, low vitamin D levels persist throughout gestation and post-delivery. Cord blood vitamin D levels correlate with those of the mother, and are significantly lower in obese women than in their normal weight counterparts. Maternal vitamin D levels exhibit a significant negative relationship with HbA 1c levels, supporting a potential role for this vitamin in maintaining glycaemic control.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Maternal vitamin D status in Type 1 diabetic pregnancy: Impact on neonatal vitamin D status and association with maternal glycaemic control

Bennett

McPeake

McCance

et al. 2014

Pregnancy Hypertension: An International Journal of Women's Car

View full text Add to dashboard Cite

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“…Observational studies already showed that vitamin D deficiency is associated with increased risks for cardiovascular disease and death in the general population (31,32), with heart failure in patients referred for coronary angiography (33) and with mortality in hemodialysis and CKD patients (34,35). Moreover low 25-(OH) vitamin D3 levels are associated with traditional atherosclerosis risk factors (36)(37)(38)(39).…”

Section: Discussionmentioning

confidence: 99%

Progression of Coronary Artery Calcification and Thoracic Aorta Calcification in Kidney Transplant Recipients

Maréchal

Coche

Goffin

et al. 2012

American Journal of Kidney Diseases

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BACKGROUND: Vascular calcification independently predicts cardiovascular disease, the major cause of death in kidney transplant recipients (KTRs). Longitudinal studies of vascular calcification in KTRs are few and small and have short follow-up. We assessed the evolution of coronary artery (CAC) and thoracic aorta calcification and their determinants in a cohort of prevalent KTRs. STUDY DESIGN: Longitudinal. SETTING PARTICIPANTS: The Agatston score of coronary arteries and thoracic aorta was measured by 16-slice spiral computed tomography in 281 KTRs. PREDICTORS: Demographic, clinical, and biochemical parameters were recorded simultaneously. OUTCOMES MEASUREMENTS: The Agatston score was measured again 3.5 or more years later. RESULTS: Repeated analyzable computed tomographic scans were available for 197 (70%) KTRs after 4.40 ± 0.28 years; they were not available for the rest of patients because of death (n = 40), atrial fibrillation (n = 1), other arrhythmias (n = 4), refusal (n = 35), or technical problems precluding confident calcium scoring (n = 4). CAC and aorta calcification scores increased significantly (by a median of 11% and 4% per year, respectively) during follow-up. By multivariable linear regression, higher baseline CAC score, history of cardiovascular event, use of a statin, and lower 25-hydroxyvitamin D(3) level were independent determinants of CAC progression. Independent determinants of aorta calcification progression were higher baseline aorta calcification score, higher pulse pressure, use of a statin, older age, higher serum phosphate level, use of aspirin, and male sex. Significant regression of CAC or aorta calcification was not observed in this cohort. LIMITATIONS: Cohort of prevalent KTRs with potential survival bias; few patients with diabetes and nonwhites, limiting the generalizability of results. CONCLUSION: In contrast to previous small short-term studies, we show that vascular calcification progression is substantial within 4 years in prevalent KTRs and is associated with several traditional and nontraditional cardiovascular risk factors, some of which are modifiable.

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“…24,32 and vitamin D intake was negatively associated with BMI in both genders. 33 Further, fat depots are proposed to be a relatively inaccessible storage location of vitamin D, 34,35 reducing the concentration of the vitamin available for conversion to 25OHD. A reduction in 25OHD concentration may then lead to an increase in fasting serum PTH.…”

Section: Discussionmentioning

confidence: 99%

Parathyroid hormone is associated with decreased fat mass in young healthy women

et al. 2005

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Objective: To investigate the relationship of parathyroid hormone (PTH) with dietary calcium and changes in body composition. Design: Cross-sectional and 1-year longitudinal trial. Subjects: Normal-weight young women (age: 18-31), 155 subjects analyzed at baseline, and data for 41 subjects analyzed prospectively between baseline and 12 months. Measurements: Levels of fasting serum calcium and PTH, intakes of calcium (3-day diet records), and total body weight and body composition (dual energy X-ray absorptiometry). Results: Baseline dietary calcium, regardless of whether unadjusted or adjusted for energy intake, did not predict baseline levels of fasting serum PTH. Change in dietary calcium also did not predict change in serum PTH. However, log PTH was significantly correlated with body fat mass (R ¼ 0.27), but not lean mass at baseline (n ¼ 155), independent of serum calcium (corrected R ¼ 0.25). Further, 12-month changes (n ¼ 41) in log PTH positively predicted the 12-month change in body weight (R ¼ 0.32) and body fat (R ¼ 0.32), but not lean mass even when controlled for age or change in serum calcium. Conclusion: Fasting serum PTH was associated with increased fat mass, in both cross-sectional and prospective analysis. Thus, serum PTH may play a role in the regulation of body fat mass in young women.

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Decreased bioavailability of vitamin D in obesity

Abstract: Obesity-associated vitamin D insufficiency is likely due to the decreased bioavailability of vitamin D(3) from cutaneous and dietary sources because of its deposition in body fat compartments.

Cited by 2,790 publications

References 16 publications

Maternal vitamin D status in Type 1 diabetic pregnancy: Impact on neonatal vitamin D status and association with maternal glycaemic control

Maternal vitamin D status in Type 1 diabetic pregnancy: Impact on neonatal vitamin D status and association with maternal glycaemic control

Progression of Coronary Artery Calcification and Thoracic Aorta Calcification in Kidney Transplant Recipients

Parathyroid hormone is associated with decreased fat mass in young healthy women

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