“…According to these studies, the number and frequency of peripheral Tregs were slightly high, significantly low or were normal in T1D patients [ 4 ]. Defective or normal suppressive function of Tregs were also reported [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. It must be highlighted, however, that these discrepancies may derive from the fact that different studies utilized either peripheral blood lymphocytes or lymphocytes residing within lymph nodes, or were carried out on samples from new onset or long-standing diabetics of different age or ethnic origin.…”